Abstract：
PURPOSE:The aim of the study was to investigate the expression of Bridge-1 in human breast carcinomas, and to determine the in vitro regulation of Bridge-1 by activin A and the influence of Bridge-1 on activin A signaling in the human breast cancer cell line MCF-7. METHOD:Bridge-1 expression in human breast carcinomas was shown after staining paraffin slides with a specific antibody against Bridge-1. To gain insight into Bridge-1 function, immortalized, human breast cancer cells (MCF-7 cell line) were stimulated with activin A and the expression of Bridge-1 was analyzed by real-time PCR and Western blot. Next, Bridge-1 was downregulated via siRNA treatment in MCF-7 cells and the expression of Bridge-1, Smad2, 3 and 4 was investigated by real-time PCR and Western blot. RESULTS:Human breast carcinoma cells showed nuclear and cytoplasmic localization of Bridge-1. Activin A stimulation of the immortalized human breast adenocarcinoma cell line MCF-7 showed an increase in Bridge-1 expression by real-time PCR and Western blot. Downregulation of Bridge-1 by Bridge-1-siRNA resulted in a decreased expression of Smad2, 3 and 4 of up to 50% compared to the treatment with non-targeting siRNA. CONCLUSIONS:This study is the first to demonstrate the expression of Bridge-1 in human breast carcinomas. Bridge-1 expression is increased by activin A stimulation and itself seems to influence activin A signaling by affecting the expression of Smad2, 3 and 4.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Banz-Jansen C,Münchow B,Diedrich K,Finas Ddoi
10.1007/s00404-011-1875-0subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1543-9issue
6eissn
0932-0067issn
1432-0711journal_volume
284pub_type
杂志文章abstract：PURPOSE:To evaluate the prevalence of cervical pre-malignancies in the cervical cytology of female renal transplant recipients (RTR) and compare to immunocompetent patients. METHODS:A prospective case-control study of 165 RTR (cases) and 372 immunocompetent women (controls) was carried out from May 2015 to August 2016...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05621-3
更新日期：2020-09-01 00:00:00
abstract：:A consanguineous family with no living children and three male siblings with Pena-Shokeir 1 syndrome is described. Two children died antepartum and the third shortly after delivery. The importance of early prenatal diagnosis, appropriate counseling and thorough evaluation of the neuromuscular system is discussed. ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02718378
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:Human papillomavirus (HPV) can cause condylomata acuminata, also known as genital warts. Our aim was to evaluate the long-term recurrence of genital warts after primary carbon dioxide laser treatment before the introduction of the vaccination against HPV. METHODS:Recurrence rate and localization of genital war...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05242-5
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Splenic cysts or masses in pregnancy are extremely rare and only five cases were described in the literature. We present the first case of splenic cyst in pregnancy treated laparoscopically with fenestration and preservation of the spleen. CASE:A 23-year-old primigravida at 9 weeks of gestation presented fo...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-006-0229-9
更新日期：2007-04-01 00:00:00
abstract：:Primary malignant tumors of the breast are the most frequently occurring neoplasms in women whereas breast metastases are rare. We report the first case, in literature, of metastasis within the breast resulting from a previous cecum carcinoma. We discuss the case and review the literature. ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s004040000158
更新日期：2001-11-01 00:00:00
abstract：:The effect of stress during labour on the plasma concentration of prolactin and cortisol was studied in 30 healthy multiparous women. The plasma concentrations of prolactin and cortisol were measured by radioimmunoassay during oxytocin induced labour, spontaneous labour, delivery and postpartum 24 h. The parturients w...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF01560086
更新日期：1989-01-01 00:00:00
abstract：:We have examined the predictive value of measurements of CASA (Cancer Associated Serum Antigen) levels in patients with breast carcinoma. The measurement uses monoclonal antibodies that bind to an epitope on the polymorphic epithelial mucin. CASA levels were of less value compared with the levels of other tumor marker...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s004040050215
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of tamoxifen administration with letrozole in the context of intrauterine insemination (IUI) cycles. MATERIALS AND METHODS:This prospective double-blinded study included 130 patients. After randomization, 65 patients in group A received letrozole + tamoxifen and human menopausal g...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-012-2556-3
更新日期：2013-02-01 00:00:00
abstract：:We here report a case of trisomy 21 with congenital chylothorax. The patient was a male newborn who had been diagnosed as having trisomy 21 with congenital chylothorax. This is the fifth case of the both conditions in English literature. Congenital chylothorax is very rare in a trisomy 21 patient. There, however, may ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02389608
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To assess adverse pregnancy outcomes in patients complicated with mild or severe Hyperemesis Gravidarum (HG). METHODS:A retrospective cohort study of women aged 18-45 with a singleton pregnancy that were admitted to the gynecological ward at the Soroka University Medical Center due to HG between the years 2013...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05192-y
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:The objective of the following study is to report the experience acquired from 24 percutaneous fetal surgeries for cavity drainage using epidural catheter instead of the commercially available catheter. METHODS:Twenty-four percutaneous fetal surgeries for cavity drainage were performed, due to the following ...
journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章
doi：10.1007/s00404-006-0283-3
更新日期：2007-07-01 00:00:00
abstract：INTRODUCTION:Although breast cancer is a major health problem worldwide, metastatic disease to the lower genital tract remains to be a rare event. CASE REPORT:A 64-year old woman was admitted to our hospital due to newly diagnosed ascites and peripheral edema. A computer tomography had shown peritoneal carcinosis but ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-1843-8
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Transversus abdominis plane (TAP) block has been shown to provide pain relief after abdominal procedures. However, TAP block combined with multimodal analgesia technique have not been assessed in a randomized controlled trial. This randomized, controlled, observer-blinded study was designed to evaluate the a...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-012-2698-3
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:To examine the clinicopathological characteristics of pregnant women who presented with intermittent hemorrhage occurring throughout pregnancy until delivery. METHOD:A total of 24 women with intermittent hemorrhage occurring throughout pregnancy were categorized into two groups, a group with persistent subch...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-2972-z
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:This study is designed to explore the correlation between AMH levels and IR in normal weight PCOS women. MATERIALS AND METHODS:This prospective study was conducted on 55 patients, who were admitted to obstetrics and gynecology department of a university clinic. Study group was consisted of 34 patients diagnose...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-2833-9
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:The growing popularity and acceptance of integrative medicine is evident both among patients and among the oncologists treating them. As little data are available regarding health-care professionals' knowledge, attitudes, and practices relating to the topic, a nationwide online survey was designed. METHODS:Ove...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-017-4420-y
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To explore the etiologic factors and treatments of iatrogenic ureteral and bladder injury during obstetric and gynecologic operations. METHODS:Forty-one patients who underwent traditional obstetric and gynecologic operations were found with iatrogenic ureteral and bladder injury, and recruited into our study...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-2075-7
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:Chemokines have been implicated in the pathological process of endometriosis. We compared the effects of peritoneal fluid obtained from patients with endometriosis (ePF) and controls without endometriosis (cPF) on the release of monocyte-specific CC chemokines such as monocyte chemotactic protein-1 (MCP-1), reg...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1583-1
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Cervical cancer is the second most common cancer of the genital tract. Wide use of screening programs can help in prevention of cervical cancer. OBJECTIVE:To screen and evaluate the prevalence of cervical intraepithelial neoplasia (CIN) by visualization of the cervix after application of 5 % acetic acid (VI...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-3109-0
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:To evaluate maternal and neonatal outcomes at and beyond term associated with induction of labor compared to spontaneous onset of labor stratified by week of gestational age. METHODS:In this retrospective cohort study, data form 402,960 singleton pregnancies from the Austria Perinatal Registry were used to est...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-017-4354-4
更新日期：2017-05-01 00:00:00
abstract：:With hypervolemia, hemoconcentration, high vascular resistance and hypertension the SIH offers opposite changes as the physiological pregnancy. The absence of a decrease in hematocrit and MAP is as yet not used as early screening possibility. Doppler flow measurements allow a detection of a fetal brain sparing effect ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/BF02417259
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:The aim of the study was to evaluate the factors that may affect experienced pain during office hysteroscopy performed without anesthesia in an outpatient setting. MATERIALS AND METHODS:We enrolled the patients into six groups, differentiated by parity, menopausal status and type of the sheath that was us...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-012-2667-x
更新日期：2013-05-01 00:00:00
abstract：:For clinical purposes, diagnostic added value of HE4 is important. Diagnostic knowledge is not provided by answering the question, "How accurate is this test?" (test accuracy research). Diagnostic knowledge is the information needed to answer the question, "What is the probability of the presence or absence of a speci...
journal_title：Archives of gynecology and obstetrics
pub_type： 评论,信件
doi：10.1007/s00404-020-05681-5
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Surgical management of posterior vaginal wall prolapse has variable functional outcomes. Synthetic and biological grafts are used to improve outcomes and reduce failures. The objective of this study was to determine the functional outcomes and its implications on patient-reported quality of life of a technique ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3254-0
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To compare the subjective and objective cure rates, postoperative pain, postoperative complications, and postoperative quality of life of adjustable single-incision sling (Ajust®) versus tension-free vaginal tape-obturator (TVT-O™) in the treatment of female stress urinary incontinence (SUI). METHODS:Female pa...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-015-3949-x
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:The aim of our study was to evaluate the platelet function in unexplained recurrent miscarriage and to investigate whether any hematologic changes detectable by simple complete blood count have a diagnostic value for the prediction of unexplained recurrent miscarriage. METHODS:A prospective study based on the ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3192-x
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Membranous dysmenorrhea is a rare entity involving expulsion of fragments of endometrium retaining the shape of the uterus. The condition is often linked to high progesterone levels. An association with a chronic fatigue syndrome was never described. CASE:A 44-year-old woman with a chronic fatigue syndrome ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-008-0795-0
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:This prospective study investigated associations between prenatal attachment of adult first-time mothers to the unborn child, perinatal factors and levels of depression before and up to 18 months after delivery. METHOD:Primiparas (N = 161) without specific risk factors answered the following questionnaires dur...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-012-2286-6
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:In general, male and female are prescribed the same amount of dosage even if most of the cases female required less dosage than male. Physicians are often facing problem on appropriate drug dosing, efficient treatment, and drug safety for a female in general. To identify and synthesize evidence about the effect...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-017-4363-3
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:To review the effect of intravenous magnesium in obstetrics on fetal/neonatal neuroprotection. METHODS:A systematic review of published studies. RESULTS:Five randomized trials and 4 meta-analyses have shown a significant 32% reduction of cerebral palsy when administering magnesium sulfate in case of preterm d...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-014-3581-1
更新日期：2015-05-01 00:00:00
