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Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET.

Abstract：

PURPOSE:The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women with DOR undergoing assisted reproduction. METHODS:This was a single-center retrospective cohort study. A total of 2277 IVF-ET or ICSI cycles from 1957 DOR women were analysed. Impact factors of LB rate were explored via Student's t test, Pearson's Chi-square test, and multivariate logistic regression models. RESULTS:There were statistically significant differences in maternal age (P < 0.001), duration of infertility (P < 0.001), female body mass index (P = 0.039), first IVF cycle (P = 0.004), poor ovarian response (P < 0.001), paternal age (P < 0.001), total gonadotropin dose (P = 0.010), endometrial thickness (P = 0.021), number of follicles ≥ 14 mm (P = 0.007), number of oocytes retrieved (P < 0.001), number of frozen embryos (P = 0.014), and the stage (P < 0.001) and number (P < 0.001) of embryos transferred between the non-live-birth (NLB) and LB groups. However, only factors of maternal age, the stage and number of embryos transferred remained different after adjusting for potential confounders. CONCLUSIONS:Maternal age, the stage and number of embryos transferred were independent impact factors affecting the live-birth rate in women with DOR seeking for assisted conception.

journal_name

Arch Gynecol Obstet

journal_title

Archives of gynecology and obstetrics

authors

Huang Y,Li J,Zhang F,Liu Y,Xu G,Guo J,Zhang R,Wu Y,Liu J,Chen K,Zhao W,Wu W,Hu Y,Chen G,Zhang D

doi

10.1007/s00404-018-4884-4

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1017-1027

issue

5

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-018-4884-4

journal_volume

298

pub_type

杂志文章

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