Bilateral pheochromocytoma during the postpartum period.

Abstract:

BACKGROUND:Pheochromocytoma manifesting during pregnancy is uncommon but it is responsible for a high maternal and fetal mortality rate, especially when unrecognized. Most cases of pheochromocytoma are sporadic but they can be part of hereditary autosomal dominant syndromes. CASE:We describe a case of bilateral pheochromocytoma in a term-pregnant patient with a previous history of medullary thyroid carcinoma (MTC). Her genetic study revealed a heterozygous mutation, c.1900T>C, in the RET proto-oncogene which confirmed the diagnosis of multiple endocrine neoplasia type 2A (MEN2A). Unrecognized, the tumors caused a crisis with fatal outcome in the mother during the postpartum period. This event might have been prevented if the tumor had been detected previously. CONCLUSION:MEN2A affected pregnancy is an unusual condition. This syndrome should be suspected when a pregnant patient has a history of MTC. Early detection and appropriate management can prevent serious maternal and fetal complications. We also reviewed the literature of MEN2A-affected pregnancies.

journal_name

Arch Gynecol Obstet

authors

Wattanachanya L,Bunworasate U,Plengpanich W,Houngngam N,Buranasupkajorn P,Sunthornyothin S,Shotelersuk V,Snabboon T

doi

10.1007/s00404-009-1057-5

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1055-8

issue

6

eissn

0932-0067

issn

1432-0711

journal_volume

280

pub_type

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