Abstract：
PURPOSE:Colposcopy-directed biopsy is a cornerstone method for diagnosing cervical intraepithelial neoplasia. The aim of this study was to evaluate the accuracy of colposcopy-directed biopsy in comparison with definitive surgery. METHODS:The accuracy of colposcopy-directed biopsy was compared with the final histology in relation to different types of transformation zone (TZ), the patient's age, and the examiner's level of training. RESULTS:The overall accuracy of biopsy in comparison with definitive surgery was 71.9% for all entities-benign lesions, low-grade squamous intraepithelial lesions, high-grade squamous intraepithelial lesions (HSILs), and cervical carcinoma-with an underdiagnosis rate of 11.8% and an overdiagnosis rate of 16.5%. The accuracy for detecting HSIL was 88% (401/455), with an underdiagnosis rate of 10.5% and overdiagnosis rate of 1.3%. The accuracy rates for detecting HSIL in women with TZ 1, TZ 2, or TZ 3 were 92.2, 90.5, and 76.5%, respectively. The accuracy rates for detecting HSIL in the different age groups were 93.1% (age 0-34), 83.6% (age 34-55), and 80% (age 55 or older). CONCLUSIONS:A combination of the colposcopic findings, cytology, human papillomavirus testing, and colposcopy-directed biopsy is necessary for the correct diagnosis of HSIL. The accuracy rate depends on the TZ and the patient's age. The examiner's level of training does not have any substantial influence on the accuracy.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Stuebs FA,Schulmeyer CE,Mehlhorn G,Gass P,Kehl S,Renner SK,Renner SP,Geppert C,Adler W,Hartmann A,Beckmann MW,Koch MCdoi
10.1007/s00404-018-4953-8subject
Has Abstractpub_date
2019-02-01 00:00:00pages
525-532issue
2eissn
0932-0067issn
1432-0711pii
10.1007/s00404-018-4953-8journal_volume
299pub_type
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