Abstract：
PURPOSE:Adenomyosis is a benign uterine disease resulting from the myometrial invasion of the endometrial gland and stroma. In the current study, angiogenesis, apoptosis and energy metabolism were investigated in adenomyosis. METHODS:A retrospective study was performed using paraffin archival tissues. Three groups were included in the study: Group I and Group II; ectopic and eutopic endometrial tissues of patients with adenomyosis, respectively, and Control Group; endometrial tissue of individuals without adenomyosis. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), intercellular adhesion molecule 1 (ICAM-1) and hypoxia-inducible factor 1 alpha (HIF-1A) levels were evaluated as angiogenic markers. Bcl-2, caspase-9 and caspase-3 levels were investigated as apoptotic indicators, and isocitrate dehydrogenase 1 (IDH1), succinate dehydrogenase complex subunit C (SDHC) and fumarate hydratase (FH) levels were also examined as energy metabolism markers. Gene expression levels of all parameters were determined by RT-PCR. RESULT:VEGF expression levels were found to be increased in Group I according to the control group and Group II. Bcl-2 expression levels were found to be increased in the Group I compared to the Group II. It was determined that expression levels of IDH1 were decreased in the Group I and Group II compared to the Control Group. There was no significant difference in the other examined parameters. Although we did not find a significant difference in HIF-1A levels between the groups, we found a positive correlation between VEGF and HIF-1A in the Group I. CONCLUSION:These results point out that VEGF, HIF-1A, Bcl-2 and IDH1 may be associated with the etiology of adenomyosis.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Yalaza C,Canacankatan N,Gürses İ,Aytan H,Taşdelen Bdoi
10.1007/s00404-020-05742-9subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1221-1227issue
5eissn
0932-0067issn
1432-0711pii
10.1007/s00404-020-05742-9journal_volume
302pub_type
杂志文章abstract：PURPOSE:This study was carried out to determine the relationship between breast arterial calcification (BAC) and cerebral artery disease. MATERIALS AND METHODS:We investigated the relationship between BAC on mammography and cerebral artery-origin T2-hyperintensity on brain MRI and which is associated with an increased...
journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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doi：10.1007/BF00932273
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析,评审
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更新日期：2018-04-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05347-x
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journal_title：Archives of gynecology and obstetrics
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doi：10.1007/s00404-008-0806-1
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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