Abstract:
AIM:The aim of this study was to compare the efficacy and safety of two combination regimens in the syndromic management of lower genital infection. Seventy-two non-pregnant women presenting with symptoms of lower genital infection diagnosed as vaginitis on clinical examination and lacking obvious upper genital infection were enrolled to one of the two treatment regimens as a syndromic treatment. No investigations were performed to cut the cost and to avoid the loss of patients on follow-up. Thirty-seven women (group I) were prescribed a course of clotrimazole (Imidil, Lyka) 100 mg vaginal pessaries for 6 days. Along with their partners they were prescribed 2 gm secnidazole (Secnil forte) and 150 mg fluconazole (Syscan) as a single therapy. Thirty-five women (group II) were prescribed vaginal clotrimazole as mentioned above. A combination kit containing 150 mg fluconazole, 2 gm secnidazole and 1 gm azithromycin (FAS-3 kit, Lyka) was also prescribed to both partners with the advice to take azithromycin on empty stomach, and the other three tablets after food. RESULTS:All women in both groups were seen after 1 week for relief of symptoms and after 1 month for any recurrence. Mean parity was 2.7 and 3.0, respectively. The total symptomatic relief was observed in 67.6 and 94.3% cases, partial relief in 27 and 5.7% cases and no relief was observed in 5.4% and nil cases, respectively, in the two groups. Recurrence was seen in two and nil cases, respectively, in the two groups. Most women tolerated both the treatments well with no major side effect in any case. Treatment cost was higher in group II (Rupees 120) than in group I (Rupees 65). CONCLUSIONS:Both combination kits with local clotrimazole were reasonably effective and safe in the syndromic approach for lower genital infections. The combination kit with azithromycin, secnidazole and fluconazole was more effective with better symptomatic relief and less recurrence rate and may be routinely recommended in all cases of lower genital infection as a cost effective, safe and effective strategy.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Sharma JB,Mittal S,Raina U,Chanana Cdoi
10.1007/s00404-005-0071-5subject
Has Abstractpub_date
2006-01-01 00:00:00pages
232-5issue
4eissn
0932-0067issn
1432-0711journal_volume
273pub_type
临床试验,杂志文章abstract:OBJECTIVE:Fetal congenital cystic adenomatoid malformation (CCAM) is a rare lung abnormality with a highly variable prognosis depended on the presence of fetal hydrops and the size of the cysts. In case of fetal hydrops the prognosis is fatal without intervention. METHODS AND DESIGN:Case report and literature review. ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-008-0880-4
更新日期:2009-08-01 00:00:00
abstract::Intrauterine devices are a very effective form of contraception used worldwide for more than 2 centuries. One of the serious, but rare, complications of intrauterine contraception is perforation through the uterine wall into the pelvic or abdominal cavity. In this report we describe, persistent periumbilical discharge...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0477-3
更新日期:2008-05-01 00:00:00
abstract::Dihydroergotamine is a vasoactive drug which enhances venous tone, central blood volume and cardiac output but has variable effects on arterial tone. Its effect on the uterine arterial circulation is unstudied and yet dihydroergotamine is widely used to treat postural hypotension in pregnant and nonpregnant women. For...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02718385
更新日期:1992-01-01 00:00:00
abstract::Tubal sterilization is one of the options chosen by the women who have completed their fertility. Although ectopic pregnancy after tubal sterilization is rare, all women undergoing this procedure should be informed about the risk of it. An ectopic pregnancy in a 36-year-old woman who had undergone tubal sterilization ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/pl00007502
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effect of postpartum counseling on postpartum contraceptive use. METHODS:One hundred and forty-three women who delivered between 1 January 2004 and 31 September 2004 and counseled about postpartum contraception were included in the study. The participants were interv...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-006-0287-z
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To evaluate the clinical outcomes after fresh transfer of blastocysts cultured from vitrified-thawed cleavage embryos (VTCE) compared with conventional frozen-thawed blastocysts transfer (FBT), or with the usual fresh blastocysts transfer (FRBT). METHODS:A total of 155 cycles undergoing fresh transfer of VTCE ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-019-05236-3
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abstract:OBJECTIVE:To evaluate the effect of a course of corticosteroids on platelet count in both thrombocytopenic and normal pregnant women. STUDY DESIGN:We retrospectively considered 107 pregnant women at 24-34 weeks gestation, who had received betametasone treatment (12 mg i.m. for two consecutive days) for fetal lung matu...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-006-0141-3
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Primitive neuroectodermal tumors of uterus (PNET) are extremely rare in tumors of the female genital system and therefore there is no sufficient information about their diagnosis, treatment, and follow-up. CASE:The case is a 32-year-old, operated in emergency conditions due to intra-abdominal hemorrhage, an...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0699-z
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:Human papillomavirus (HPV) can cause condylomata acuminata, also known as genital warts. Our aim was to evaluate the long-term recurrence of genital warts after primary carbon dioxide laser treatment before the introduction of the vaccination against HPV. METHODS:Recurrence rate and localization of genital war...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-019-05242-5
更新日期:2019-09-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040050239
更新日期:1999-01-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2150-0
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and safety of fentanyl iontophoretic transdermal system (ITS) with morphine intravenous patient-controlled analgesia (IV PCA) for pain management following gynecologic surgery. METHOD:A subgroup (n = 275) of gynecologic surgery patients from a randomized study (N = 636) of patients tr...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00404-007-0339-z
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To compare the pregnancy outcomes between women who were treated with cold-coagulation versus large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia. METHODS:This was a retrospective cohort study of women who had a single cervical treatment between 2010 and 2011. We ident...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-018-4704-x
更新日期:2018-04-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-009-1328-1
更新日期:2011-02-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-2988-4
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:Conotruncal defects represent an anatomically heterogeneous group of cardiac malformations affecting the outflow tract of the ventricles and the arterial pole of the heart. The exact etiology of congenital heart diseases is unknown. CASE REPORT:A 31-year-old woman who had three offspring with complex cono...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0367-8
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the effectiveness of short-term maintenance treatment with cabergoline and to find out minimum effective dosage of cabergoline during maintenance treatment for patients with microadenoma-related and idiopathic hyperprolactinemia. STUDY DESIGN:Cabergoline was administered orally ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-010-1562-6
更新日期:2010-11-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
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abstract:PURPOSE:Recent evidence suggests that ADP-ribosylation factor-like tumor suppressor gene 1(ARLTS1) may act as a tumor suppressor gene. However, its role in tumor chemotherapy remains unclear. The aim of this study is to investigate the effects of ARLTS1 gene in regulation of chemosensitivity in ovarian cystadenocarcino...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1782-9
更新日期:2011-11-01 00:00:00
abstract::Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign, and almost all are localised unilaterally. Herewith, we describe an ovarian Sertoli-Leydig cell tumor in an 11-year-old girl. Serum ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040000114
更新日期:2001-01-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040000095
更新日期:2000-11-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-015-3642-0
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:Recent literature evaluating the optimal timing for external cephalic version (ECV) in non-cephalic presentation is limited and hampered by methodological issues. We aimed to compare late preterm ECV [term (36-37 weeks of gestation] to term ECV ( > 37 weeks). METHODS:We conducted a retrospective cohort study o...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-019-05244-3
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:To compare the efficacy of a personal dietary intervention on gestational weight gain control with a general intervention promoting healthy eating. METHODS:Prospective, controlled study including 154 low-risk pregnant women randomly allocated to two groups: 77 receiving a personalized diet plan and a close fol...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-013-3054-y
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of tamoxifen administration with letrozole in the context of intrauterine insemination (IUI) cycles. MATERIALS AND METHODS:This prospective double-blinded study included 130 patients. After randomization, 65 patients in group A received letrozole + tamoxifen and human menopausal g...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-012-2556-3
更新日期:2013-02-01 00:00:00
abstract::The fertility and pregnancy outcomes of the patients were studied, who previously underwent preservative operation for malignant tumors, including those of borderline malignancy, in our ward from 1981 to 1995. For each of the 9 patients, unilateral ovary was preserved, the range of their ages before operation was 10 t...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040000094
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:Hypoxia inducible factor-1α (HIF-1α), regulated in development and DNA damage response-1 (REDD1), and mammalian target of rapamycin (mTOR) play distinct roles in response to hypoxia. The aim of this study was to evaluate whether the HIF-1α-REDD1-mTOR-mediated hypoxic stress response also operates normally in es...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-016-4186-7
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Schistosomiasis is a disease prevalent throughout the world, but the involvement of ovary by Schistosoma mansoni eggs is rarely found. The pathological mechanisms involved in the infestation of the ovary remain unknown and the diagnosis usually occurs, retrospectively, by histopathological examination. An un...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-009-1091-3
更新日期:2010-01-01 00:00:00
abstract::In spite of menstrual bleedings during premenopause FSH-concentration in blood increases significantly, however, without reaching post-menopausal amounts. Sometimes it is correlated with climacteric symptoms. FSH increases already 10 years before menopause, whereas LH does not change. Responsible for that is the parti...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/BF02417644
更新日期:1989-01-01 00:00:00