Abstract:
OBJECTIVE:To compare the efficacy and safety of fentanyl iontophoretic transdermal system (ITS) with morphine intravenous patient-controlled analgesia (IV PCA) for pain management following gynecologic surgery. METHOD:A subgroup (n = 275) of gynecologic surgery patients from a randomized study (N = 636) of patients treated with fentanyl ITS or morphine IV PCA was analyzed. The main efficacy endpoint was the patient global assessment (PGA) of the method of pain control (first 24 h). RESULT:In gynecologic surgery patients, PGA success ratings (excellent/good) were statistically equivalent (fentanyl ITS, 84.8%; morphine IV PCA, 83.9%; 95% confidence interval: -7.7%, 9.4%) based on the prespecified equivalence criterion of 10% for the entire study population. Pain intensity at 3 h (P = 0.296), discontinuations due to inadequate analgesia (P = 0.148), and percentages of patients requesting supplemental opioids in the first 3 h (P = 0.524) were similar. CONCLUSION:The two modalities were therapeutically equivalent for pain management in these gynecologic surgery patients.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Ahmad S,Hewitt DJ,Damaraju CVdoi
10.1007/s00404-007-0339-zsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
251-8issue
3eissn
0932-0067issn
1432-0711journal_volume
276pub_type
杂志文章,多中心研究,随机对照试验abstract:PURPOSE:We sought to evaluate the impact of obesity on the risk of spontaneous and medically indicated preterm birth in young women compared to adult women. METHODS:Florida vital records from 2004 to 2007 were used to obtain data. The study sample consisted of 290,807 mothers of whom 4,739 were adolescent girls < or =...
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journal_title:Archives of gynecology and obstetrics
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journal_title:Archives of gynecology and obstetrics
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