High mean platelet volume, low-grade systemic coagulation and fibrinolytic activation are associated with androgen and insulin levels in polycystic ovary syndrome.

Abstract:

OBJECTIVES:The present study was designed to determine (a) the coagulation parameters, WBC and MPV levels; (b) whether there was any association between androgen and mean platelet volume and low-grade systemic coagulation in PCOS patients. METHODS:A total of 48 patients with non-diabetic PCOS were studied in order to evaluate and compare with a non-PCOS group of 30 subjects. RESULTS:D-dimer, homeostatic model assessment (HOMA-IR), insulin, androgens, glucose, WBC and MPV concentrations were higher in women with PCOS. No difference was observed in fibrinogen, activated partial thromboplastin time and prothrombin time values between the two groups. Free testosterone was positively correlated with D-dimer, insulin, DHEAS, and MPV levels. In multiple stepwise regression analyses, free testosterone positively associated with D-dimer and DHEAS. MPV was positively correlated with insulin levels, HOMA-IR values, DHEAS and free testosterone levels in PCOS patients. In multiple stepwise regression analyses, MPV positively associated with insulin and DHEAS. CONCLUSION:PCOS patients had low-grade systemic coagulation and fibrinolytic activation as evidenced by elevated D-dimer, and increased WBC and MPV levels suggesting that hematological parameters could potentially be used as indicators of risk factor for atherosclerosis in PCOS women.

journal_name

Arch Gynecol Obstet

authors

Kebapcilar L,Taner CE,Kebapcilar AG,Sari I

doi

10.1007/s00404-008-0884-0

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

187-93

issue

2

eissn

0932-0067

issn

1432-0711

journal_volume

280

pub_type

杂志文章
  • Survivors of primary breast cancer 5 years after surgery: follow-up care, long-term problems, and treatment regrets. Results of the prospective BRENDA II-study.

    abstract:PURPOSE:This study aims to answer the questions where breast cancer patients in Germany receive follow-up care (with what types of doctors) and what are the long-term problems and treatment regrets of breast cancer patients. METHODS:In the prospective multicenter cohort study BRENDA II ("Breast Cancer under Evidence-B...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00404-020-05437-1

    authors: Leinert E,Kreienberg R,Wöckel A,Kühn T,Flock F,Felberbaum R,Janni W,Taylor K,Singer S,Schwentner L,BRENDA study group.

    更新日期:2020-03-01 00:00:00

  • Minimally invasive surgery for endometrial cancer: a comprehensive review.

    abstract:PURPOSE OF REVIEW:The objective of this article is to review the recently published literature on the use of minimally invasive surgical approaches for patients with endometrial cancer. METHODS:Narrative review of the pertinent literature on traditional laparoscopy and robotically assisted laparoscopy for the treatmen...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00404-014-3517-9

    authors: Rabinovich A

    更新日期:2015-04-01 00:00:00

  • Gestational intestinal obstruction: a case report and review of literature.

    abstract::Intestinal obstruction in pregnancy is rare and difficult to diagnose. Common causes of gestational intestinal obstruction include adhesions, volvulus, intussuscetion, carcinoma, hernia and appendicitis [3]. Abdominal pain is a common feature, but the displacement of abdominal organs as pregnancy progresses results in...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00404-005-0097-8

    authors: Kalu E,Sherriff E,Alsibai MA,Haidar M

    更新日期:2006-04-01 00:00:00

  • Three- and four-dimensional HDlive rendering images of normal and abnormal fetuses: pictorial essay.

    abstract:BACKGROUND:Our objective is to present our experience of normal embryonic development and fetal anatomy and fetal anomalies reconstructed employing the three-dimensional (3D) and four-dimensional (4D) HDlive rendering mode. METHODS:A total of 18 normal embryos and fetuses and 21 abnormal fetuses (one case each of thor...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-012-2505-1

    authors: Hata T,Hanaoka U,Tenkumo C,Sato M,Tanaka H,Ishimura M

    更新日期:2012-12-01 00:00:00

  • Is parturition-timing machinery related to the number of inhibitor CD94/NKG2A positive uterine natural killer cells?

    abstract:PURPOSE:Prematurity is the most common cause of infant mortality and morbidity. To prevent this, the timing of parturition and its mechanisms should be understood. It is likely that inhibitor CD94/NKG2A positive decidual natural killer cells (uNK) provide for the continuation of pregnancy. Here, we aimed to evaluate wh...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-015-3978-5

    authors: Mazi E,Altunkaynak Z,Aydin I,Kocak I,Guven D,Turkmen AP,Yildiran A

    更新日期:2016-08-01 00:00:00

  • Molecular analysis of miscarriage products using multiplex ligation-dependent probe amplification (MLPA): alternative to conventional karyotype analysis.

    abstract:PURPOSE:The present study aims to evaluate whether multiplex ligation-dependent probe amplification (MLPA) technique with subtelomeric probes is to be an alternative method of routine G-banding chromosome analysis from pregnancy loss. METHODS:A review of 5 years (from 2005 to 2009) of karyotype for products of concept...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-014-3403-5

    authors: Kim JW,Lyu SW,Sung SR,Park JE,Cha DH,Yoon TK,Ko JJ,Shim SH

    更新日期:2015-02-01 00:00:00

  • Cancer associated serum antigen (CASA) levels in patients with breast carcinoma and in 3 control groups without breast cancer.

    abstract::We have examined the predictive value of measurements of CASA (Cancer Associated Serum Antigen) levels in patients with breast carcinoma. The measurement uses monoclonal antibodies that bind to an epitope on the polymorphic epithelial mucin. CASA levels were of less value compared with the levels of other tumor marker...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s004040050215

    authors: Meisel M,Weise J,Schwesinger G,Straube W

    更新日期:1998-01-01 00:00:00

  • Preeclampsia and depression: a case-control study in Tehran.

    abstract:PURPOSE:This study was conducted to determine the correlation between preeclampsia and depression. METHODS:Participants in this study included 156 cases with preeclampsia and 156 controls without any history of preeclampsia who were all newly admitted to antepartum wards, emergency room wards, and labor and delivery w...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-012-2260-3

    authors: Kharaghani R,Geranmaye M,Janani L,Hantooshzade S,Arbabi M,Rahmani Bilandi R,Bagheri F

    更新日期:2012-07-01 00:00:00

  • Prenatal diagnosis of fetal akinesia deformation sequence (FADS): a study of 79 consecutive cases.

    abstract:PURPOSE:Fetal akinesia deformation sequence (FADS) is a clinically and genetically heterogenous disorder. In this study, the different sonographic abnormalities are described in a larger number of affected fetuses. METHODS:This retrospective study included 79 cases of suspected FADS observed in our tertiary referral c...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-016-4017-x

    authors: Hellmund A,Berg C,Geipel A,Müller A,Gembruch U

    更新日期:2016-10-01 00:00:00

  • An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment? A mini review.

    abstract:INTRODUCTION:Bacterial vaginosis (BV) is the most common vaginal disorder in reproductive-age women. The condition is characterised by the replacement of a healthy, lactobacilli-dominated vaginal microbiota by anaerobic and facultative anaerobic bacteria. BV increases the risk of acquisition of STIs and is associated w...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00404-019-05142-8

    authors: Mendling W,Palmeira-de-Oliveira A,Biber S,Prasauskas V

    更新日期:2019-07-01 00:00:00

  • Topical antiseptics as an alternative in the treatment of acute vulvovaginal candidosis.

    abstract::The aim of this prospective, multicenter, randomized, case-control study was to investigate the efficacy of a nonspecific mucosal antiseptic (octenidine dihydrochloride, phenoxyethanol) with proven antifungal effects, in patients with acute symptomatic vaginal candidosis, in comparison with a specific topical antifung...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00404-002-0368-6

    authors: Friese K,Neumann G,Siebert J

    更新日期:2003-08-01 00:00:00

  • Peripheral arterial thrombosis induced by chemotherapy in ovarian carcinoma coexisted with endometrial carcinoma.

    abstract:INTRODUCTION:Most patients with peripheral arterial occlusion have underlying atherosclerosis. Peripheral arterial thrombosis induced by chemotherapy in gynecological malignancies is rare. CASE REPORT:A 60-year-old woman was diagnosed with ovarian carcinoma coexisting with endometrial carcinoma after surgical histopat...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-006-0193-4

    authors: Hida K,Ikeda S,Shimizu S,Yoshikata R,Orito S,Tatsuduki A,Ohta H

    更新日期:2007-01-01 00:00:00

  • Tranexamic acid for cesarean section: a double-blind, placebo-controlled, randomized clinical trial.

    abstract:PURPOSE:To assess the efficacy and safety of an intravenous formulation of tranexamic acid to reduce intrapartum and postpartum bleeding in patients giving birth by cesarean section. METHODS:Healthy women with normal pregnancies, at any gestational age, that we performed ceaserean section. Two hundred and twenty-three...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00404-012-2624-8

    authors: Sentürk MB,Cakmak Y,Yildiz G,Yildiz P

    更新日期:2013-04-01 00:00:00

  • Methotrexate versus hyperosomolar glucose in the treatment of extrauterine pregnancy.

    abstract::The aim of this prospective, randomized, double blind study was to compare the efficacy of methotrexate and hyperosmolar glucose injected directly into the extra-uterine gestational sac under laparoscopic vision. The study included twenty women with ectopic pregnancy. Inclusion criteria were intact tubal pregnancy, no...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s004040000149

    authors: Sadan O,Ginath S,Debby A,Rotmensch S,Golan A,Zakut H,Glezerman M

    更新日期:2001-05-01 00:00:00

  • Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening.

    abstract:PURPOSE:The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma prot...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-013-2712-4

    authors: Aytan H,Caliskan AC,Demirturk F,Sahin S,Erdogan F,Kuzu Z

    更新日期:2013-06-01 00:00:00

  • Cesarean section rate differences by migration indicators.

    abstract:PURPOSE:To answer the question: are there differences in cesarean section rates among childbearing women in Canada according to selected migration indicators? METHODS:Secondary analyses of 3,500 low-risk women who had given birth between January 2003 and April 2004 in one of ten hospitals in the major Canadian migrant...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-012-2609-7

    authors: Gagnon AJ,Van Hulst A,Merry L,George A,Saucier JF,Stanger E,Wahoush O,Stewart DE

    更新日期:2013-04-01 00:00:00

  • Could platelet distribution width be a predictive marker for unexplained recurrent miscarriage?

    abstract:PURPOSE:The aim of our study was to evaluate the platelet function in unexplained recurrent miscarriage and to investigate whether any hematologic changes detectable by simple complete blood count have a diagnostic value for the prediction of unexplained recurrent miscarriage. METHODS:A prospective study based on the ...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-014-3192-x

    authors: Mete Ural U,Bayoğlu Tekin Y,Balik G,Kir Şahin F,Colak S

    更新日期:2014-08-01 00:00:00

  • Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study.

    abstract:PURPOSE:Prevention of postpartum haemorrhage (PPH) is essential in the pursuit of improved health care for women. Oxytocin, the most commonly used uterotonic agent to prevent PPH, has no established the route of administration. In this study we aimed to compare whether the mode of oxytocin administration, i.e., intrave...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00404-016-4060-7

    authors: Dagdeviren H,Cengiz H,Heydarova U,Caypinar SS,Kanawati A,Guven E,Ekin M

    更新日期:2016-11-01 00:00:00

  • Cesarean section scar in 3 T magnetic resonance imaging and ultrasound: image characteristics and comparison of the methods.

    abstract:PURPOSE:Uterine rupture during labor is a rare but life-threatening complication after previous cesarean section (CS). Prenatal risk is assessed using ultrasound thickness measurement of the lower uterine segment (LUS). Due to inhomogeneous study results, however, clinical obstetrics still lacks for standard protocols ...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-018-4988-x

    authors: Hoffmann J,Exner M,Bremicker K,Grothoff M,Stumpp P,Schrey-Petersen S,Stepan H

    更新日期:2019-02-01 00:00:00

  • Involvement of ARLTS1 in chemotherapy and apoptosis in ovarian cancer cell line.

    abstract:PURPOSE:Recent evidence suggests that ADP-ribosylation factor-like tumor suppressor gene 1(ARLTS1) may act as a tumor suppressor gene. However, its role in tumor chemotherapy remains unclear. The aim of this study is to investigate the effects of ARLTS1 gene in regulation of chemosensitivity in ovarian cystadenocarcino...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-010-1782-9

    authors: Yang XY,Yu H,Peng ZL

    更新日期:2011-11-01 00:00:00

  • Altered growth trajectory in children born to mothers with gestational diabetes mellitus and preeclampsia.

    abstract:PURPOSE:Gestational diabetes mellitus (GDM) and preeclampsia are leading causes of mortality and morbidity in mothers and children. High childhood body mass index (BMI) is among their myriad of negative outcomes. However, little is known about the trajectory of the child BMI exposed to GDM and co-occurring preeclampsia...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-020-05436-2

    authors: Huang Y,Zhang W,Go K,Tsuchiya KJ,Hu J,Skupski DW,Sie SY,Nomura Y

    更新日期:2020-01-01 00:00:00

  • HPV 16 DNA in autopsy material of a metastatic cervical carcinoma.

    abstract::Human papillomavirus (HPV) DNA has been regularly detected in primary cervical carcinomas and in some metastatic lesions. Using Southern blot hybridization on autopsy material we found HPV 16 DNA in a primary cervical carcinoma and in multiple metastases therefrom. ...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/BF02718379

    authors: Ikenberg H,Teufel G,Klose B,Pfleiderer A

    更新日期:1992-01-01 00:00:00

  • A comparison between adjustable single-incision sling and tension-free vaginal tape-obturator in treating stress urinary incontinence.

    abstract:PURPOSE:To compare the subjective and objective cure rates, postoperative pain, postoperative complications, and postoperative quality of life of adjustable single-incision sling (Ajust®) versus tension-free vaginal tape-obturator (TVT-O™) in the treatment of female stress urinary incontinence (SUI). METHODS:Female pa...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00404-015-3949-x

    authors: Xin X,Song Y,Xia Z

    更新日期:2016-02-01 00:00:00

  • Comparison of pelvic floor muscle training isolated and associated with weight loss: a randomized controlled trial.

    abstract:PURPOSE:To analyze whether pelvic floor muscle training (PFMT) associated with weight loss (WL) is better than isolated PFMT to provide additional beneficial effects to urinary symptoms in women with MUI. METHODS:A randomized, simple-blind parallel controlled trial was performed and included women with MUI aged betwee...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00404-019-05319-1

    authors: de Oliveira MCE,de Oliveira de Lima VC,Pegado R,Silva-Filho EM,Fayh APT,Micussi MT

    更新日期:2019-11-01 00:00:00

  • Congenital hydrocephalus: gestational and neonatal outcomes.

    abstract:PURPOSE:To evaluate gestational and neonatal outcomes in pregnancies complicated by fetal hydrocephalus. METHODS:Retrospective analysis of 287 cases of fetal hydrocephalus followed at the Fetal Medicine Unit of the University of Campinas in the period of 1996 to 2006. RESULTS:Mean maternal age was 25 years, mean gest...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-009-1254-2

    authors: Nomura ML,Barini R,De Andrade KC,Milanez H,Simoni RZ,Peralta CF,Machado IN,Zambelli H,Maio KT

    更新日期:2010-12-01 00:00:00

  • [Assessing the extent of gynecologic tumors by a sonographic tumor score with special reference to ovarian cancer].

    abstract::Ultrasonic findings in 1317 operatively confirmed gynecological tumors were classified according to five degrees of homogeneity: I, clearly outlined solitary cysts; II, clearly outlined homogeneous tumors; III, poorly defined or slightly heterogeneous tumors; IV, marked heterogeneous tumors; V, completely heterogeneou...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/BF02417449

    authors: Schillinger H,Kliem M,Klosa W,Pohl J,Wilhelm C,Madjar H,Zalasa J

    更新日期:1989-01-01 00:00:00

  • A sensitive enzyme immunoassay for pregnancy-associated plasma protein A (PAPP-A): a possible first trimester method of screening for Down syndrome and other trisomies.

    abstract::Pregnancy-associated plasma protein A (PAPP-A) is a large glycoprotein produced mainly by the trophoblast during pregnancy and released into the maternal circulation. Its biological function is unknown. In the second trimester i.e. when Down syndrome (DS) screening is routinely performed, the level of maternal serum P...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/BF00634490

    authors: Bersinger NA,Zakher A,Huber U,Pescia G,Schneider H

    更新日期:1995-01-01 00:00:00

  • Sublingual versus vaginal misoprostol for cervical ripening before hysteroscopy: a randomized clinical trial.

    abstract:PURPOSE:To evaluate the efficacy of two routes of misoprostol (sublingual and vaginal) for cervical ripening before hysteroscopy. METHODS:One hundred and ten perimenopausal women who were referred to a tertiary hospital for surgical hysteroscopy enrolled in this double-blind randomized clinical trial. They were divide...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00404-012-2652-4

    authors: Tanha FD,Salimi S,Ghajarzadeh M

    更新日期:2013-05-01 00:00:00

  • Laparoscopical management ovarian early sex cord-stromal tumors in postmenopausal women: a proposal method.

    abstract:BACKGROUND:Ovarian sex-cord stromal tumor (SCST) comprises 5% of the ovarian neoplasm; it occurs as an ovarian mass or hemoperitoneum, and the surgical management of SCST is not well defined at early stage and in adult patients. PURPOSE OF THE STUDY:The authors tested to test the total not radical laparoscopic managem...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-010-1773-x

    authors: Tinelli A,Pellegrino M,Malvasi A,Lorusso V

    更新日期:2011-03-01 00:00:00

  • Reproductive outcome following hysteroscopic myomectomy in patients with infertility and recurrent abortions.

    abstract:OBJECTIVES:To evaluate the outcome of hysteroscopic myomectomy in patients with infertility and recurrent abortions. MATERIALS AND METHODS:This was a retrospective clinical analysis of 186 patients who underwent hysteroscopic myomectomy by monopolar electrode loop. A second-look diagnostic hysteroscopy was performed i...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-010-1531-0

    authors: Roy KK,Singla S,Baruah J,Sharma JB,Kumar S,Singh N

    更新日期:2010-11-01 00:00:00