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Sublingual versus vaginal misoprostol for cervical ripening before hysteroscopy: a randomized clinical trial.

Abstract：

PURPOSE:To evaluate the efficacy of two routes of misoprostol (sublingual and vaginal) for cervical ripening before hysteroscopy. METHODS:One hundred and ten perimenopausal women who were referred to a tertiary hospital for surgical hysteroscopy enrolled in this double-blind randomized clinical trial. They were divided into two groups to receive 400 mg misoprostol either sublingually or vaginally 6 h before hysteroscopy. The duration of dilatation, Hegar number inserted into the cervix without resistance, and hysteroscopic and drug complications were recorded for all cases. RESULTS:Forty-nine women in sublingual and 51 in vaginal group participated in the study. Dilatation time was significantly lower in sublingual group (P < 0.001). Median Hegar number passed into the cervix without resistance was 5 in sublingual versus 4 in vaginal group (P = 0.002). Cramp followed by vomiting and diarrhea were the most common side effects of misoprostol in the sublingual group, while cramp followed by vomiting was the most frequent side effect in the vaginal group. Diarrhea was not reported in the vaginal group (P = 0.008). CONCLUSION:Sublingual route of misoprostol could be considered as an effective medication before surgical hysteroscopy in perimenopausal women.

journal_name

Arch Gynecol Obstet

journal_title

Archives of gynecology and obstetrics

authors

Tanha FD,Salimi S,Ghajarzadeh M

doi

10.1007/s00404-012-2652-4

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

937-40

issue

5

eissn

0932-0067

issn

1432-0711

journal_volume

287

pub_type

杂志文章,随机对照试验

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