Abstract：
AIMS:K-Ras transcripts comprise two main isoforms: K-Ras 4A and K-Ras 4B, which act differently. The expression of both isoforms was reported in many human tissues. However, K-Ras 4B was the major expressed transcript variant. An increased expression of K-Ras 4B mRNA was reported in eutopic endometrium of endometriosis patients. In this way, we aimed to study the expression of K-Ras 4A transcript in eutopic endometrium related to endometriosis. METHODS:Employing exon4-flanking primers, K-Ras isoforms were simultaneously amplified in a RT-PCR reaction. Quantitative real-time PCR was performed using GAPDH as an internal control. K-Ras 4A transcript expression in eutopic endometrium was analyzed by ΔΔC T method. RESULTS:We identified existence of both of K-Ras 4A and K-Ras 4B in eutopic endometrium of patients and controls. Quantitative real-time analysis demonstrated that K-Ras 4A expression was 2.7-fold higher in endometriosis than non-endometriosis eutopic samples. Interestingly, this overexpression mainly occurs through the proliferative phase of menstrual cycle. CONCLUSION:The findings bring to light the eminent role of K-Ras 4A in endometriosis. This splice variant which is known for promoting apoptosis could be an effective factor in balance between proliferation and death of eutopic endometrial cells.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Shahrabi-Farahani M,Shahbazi S,Mahdian R,Amini-Moghaddam Sdoi
10.1007/s00404-014-3596-7subject
Has Abstractpub_date
2015-07-01 00:00:00pages
225-9issue
1eissn
0932-0067issn
1432-0711journal_volume
292pub_type
杂志文章abstract：INTRODUCTION:Bilateral mucinous cystadenoma of the ovary are extremely rare. These tumors are benign and might lead to abdominal distension, if no secondary symptoms occur and patient delay the consultation of physicians. CASE:A 60-year-old patient was admitted to the internal medicine department for constipation and ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0634-3
更新日期：2009-01-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
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更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Often, internet can bring a sense of anxiety rather than information and understanding to the patient. Our aim was to assess the quality of information available for patients on the management of polycystic ovarian syndrome (PCOS) on the internet. MATERIALS AND METHODS:Five search engines were searched usin...
journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0504-4
更新日期：2008-06-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0477-3
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,多中心研究
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 信件
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-004-0695-x
更新日期：2005-09-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3543-7
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-2897-6
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-0981-8
更新日期：2009-10-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-003-0590-x
更新日期：2005-01-01 00:00:00
abstract：PURPOSE:The present study aimed to assess the risk of obstetric anal sphincter injuries (OASIS) of a subsequent delivery after the previous OASIS in countries with low (Finland) and high rates (Norway and Sweden) of OASIS. METHODS:This population-based case-control study included women who experienced OASIS 1997-2002....
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05550-1
更新日期：2020-06-01 00:00:00
