Abstract:
PURPOSE:The unacceptable multiple gestation rate currently associated with in vitro fertilization (IVF) would be substantially alleviated if the routine practice of transferring more than one embryo were reconsidered. While transferring a single embryo is an effective method to reduce the clinical problem of multiple gestation, rigid adherence to this approach has been criticized for negatively impacting clinical pregnancy success in IVF. In general, single embryo transfer is viewed cautiously by IVF patients although greater acceptance would result from a more effective embryo selection method. METHODS:Selection of one embryo for fresh transfer on the basis of chromosomal normalcy should achieve the dual objective of maintaining satisfactory clinical pregnancy rates and minimizing the multiple gestation problem, because embryo aneuploidy is a major contributing factor in implantation failure and miscarriage in IVF. The initial techniques for preimplantation genetic screening unfortunately lacked sufficient sensitivity and did not yield the expected results in IVF. However, newer molecular genetic methods could be incorporated with standard IVF to bring the goal of single embryo transfer within reach. RESULTS:Aiming to make multiple embryo transfers obsolete and unnecessary, and recognizing that array comparative genomic hybridization (aCGH) will typically require an additional 12 h of laboratory time to complete, we propose adopting aCGH for mainstream use in clinical IVF practice. CONCLUSION:As aCGH technology continues to develop and becomes increasingly available at lower cost, it may soon be considered unusual for IVF laboratories to select a single embryo for fresh transfer without regard to its chromosomal competency. In this report, we provide a rationale supporting aCGH as the preferred methodology to provide a comprehensive genetic assessment of the single embryo before fresh transfer in IVF. The logistics and cost of integrating aCGH with IVF to enable fresh embryo transfer are also discussed.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Sills ES,Yang Z,Walsh DJ,Salem SAdoi
10.1007/s00404-012-2396-1subject
Has Abstractpub_date
2012-09-01 00:00:00pages
755-61issue
3eissn
0932-0067issn
1432-0711journal_volume
286pub_type
杂志文章,评审abstract:BACKGROUND:Maternal mortality ratio (more commonly cited as maternal mortality rate) is the number of maternal deaths that result from the reproductive process per 100,000 live births. Unfortunately, it is estimated that more than half of maternal deaths are not recorded as such. Worldwide data are probably based upon ...
journal_title:Archives of gynecology and obstetrics
pub_type: 社论
doi:10.1007/s00404-007-0540-0
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:Cervical cancer is the most common malignant tumors in women leading to serious morbidity and mortality worldwide, especially among developing countries. A main cause of the disease is the high-risk human papillomavirus (HR-HPV) infection. HSIL usually progress to cervical cancer, and low-grade lesions, incl...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-018-4931-1
更新日期:2019-01-01 00:00:00
abstract::Between 1989 and 1994 first trimester transcervical chorionic villus sampling was offered to 158 patients after proper counselling. The gestational age range was 9-12 weeks. The most important indication was advanced maternal age (75.4%). Adequate sampling after two, and a maximum of three attempts, was achieved in 98...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/BF02505315
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Turner syndrome (TS) is associated with deficiency of cellular and humoral immunity. However, the characteristics of lymphocyte subpopulations in Chinese women with TS have not been reported. In this study, the percentage of lymphocyte subpopulations and the mRNA expression of some transcription factors were de...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2049-9
更新日期:2012-03-01 00:00:00
abstract::In this study, our aim was to compare the effects of metformin and gonadotropin releasing hormone (GnRH) analogues in clinical and hormonal parameters in women with polycystic ovary syndrome (PCOS). There were 50 women with PCOS who were included in our study and they were divided into two groups. In this randomized t...
journal_title:Archives of gynecology and obstetrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00404-002-0344-1
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Desmoid tumors are benign neoplasms that most often arise from muscle aponeurosis and have been associated with both trauma and pregnancy. The etiology of desmoids has not been determined. CLINICAL CHARACTERISTICS:We present here four almost identical cases with desmoids occurring in the same location, the ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0830-1
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To compare the clinical and ongoing pregnancy rates between a protocol using oral dydrogesterone with human menopausal gonadotropin (HMG) for progestin-primed ovarian stimulation (PPOS) and the typical gonadotropin-releasing hormone (GnRH) antagonist regimen in women undergoing controlled ovarian hyperstimulati...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-018-4856-8
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:To determine the risk of intrapartum stillbirth among teen mothers. METHODS:The Missouri maternally linked data containing births from 1978 to 1997 were analyzed. The study group (teen mothers) was sub-divided into younger (<15 years) and older (15-19 years) teenagers. Women aged 20-24 were the referent cat...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0557-4
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:This study was conducted to determine the correlation between preeclampsia and depression. METHODS:Participants in this study included 156 cases with preeclampsia and 156 controls without any history of preeclampsia who were all newly admitted to antepartum wards, emergency room wards, and labor and delivery w...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-012-2260-3
更新日期:2012-07-01 00:00:00
abstract::Androgens play a primary role in female physiopathology. The age-related reduction in the production of ovarian and adrenal androgens may significantly affect women's health. The decline of circulating androgens results from a combination of two events: reduced ovarian production and aged-related decline in adrenal an...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-013-2969-7
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the outcome of hysteroscopic myomectomy in patients with infertility and recurrent abortions. MATERIALS AND METHODS:This was a retrospective clinical analysis of 186 patients who underwent hysteroscopic myomectomy by monopolar electrode loop. A second-look diagnostic hysteroscopy was performed i...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1531-0
更新日期:2010-11-01 00:00:00
abstract::Female genital tuberculosis is a rare disease in developed countries but it is a frequent cause of chronic pelvic inflammatory disease and infertility in undeveloped countries. A rare case of tubercular endometritis diagnosed at hysteroscopy and successfully treated in a woman with secondary infertility, is presented....
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-009-1325-4
更新日期:2010-06-01 00:00:00
abstract::Plasma and erythrocyte zinc concentrations in 45 proteinuric pre-eclamptic Chinese women were measured. There was no difference in either the plasma or erythrocyte zinc concentration between pre-eclamptic patients with and without intrauterine growth retardation. There was no correlation between either plasma or eryth...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02389541
更新日期:1990-01-01 00:00:00
abstract::Renal cell carcinoma is a rare, potentially fatal tumor that occasionally occurs during pregnancy. The probability of cure is directly related to the stage or degree of tumor dissemination. Surgical resection is the mainstay of treatment of this disease. A case of patient who was diagnosed with a renal mass in the sec...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0455-9
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To analyze whether pelvic floor muscle training (PFMT) associated with weight loss (WL) is better than isolated PFMT to provide additional beneficial effects to urinary symptoms in women with MUI. METHODS:A randomized, simple-blind parallel controlled trial was performed and included women with MUI aged betwee...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-019-05319-1
更新日期:2019-11-01 00:00:00
abstract::A 32 years old omani woman G6P4A1 at 39 weeks of pregnancy presented with complaints of headache and picture of eclampsia. Emergency caesarean section was done for maternal and foetal distress. Post caesarean section patient could not be extubated from general anaesthesia. Emergency computed tomography scan of the bra...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-009-1047-7
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:To evaluate the benefits of LT4 treatment on pregnancy outcomes in SCH women. STUDY DESIGN:PubMed [including Medline], Web of Science, Wiley, Google Scholar, Science direct and Scopus were searched for identifying and retrieving all English articles published up to May 2018 on the effects of levothyroxine trea...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,meta分析
doi:10.1007/s00404-019-05245-2
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION:With an estimated incidence of one to two per one million women, the endometrial stromal sarcoma (ESS) is a rare disease. It is subclassified into a high-grade and a prognostically better low-grade type. Evidence-based data for a standardized therapy is lacking. CASE REPORT:A 32-year-old obese nulligravid...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-005-0100-4
更新日期:2006-04-01 00:00:00
abstract::Tubal sterilization is one of the options chosen by the women who have completed their fertility. Although ectopic pregnancy after tubal sterilization is rare, all women undergoing this procedure should be informed about the risk of it. An ectopic pregnancy in a 36-year-old woman who had undergone tubal sterilization ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/pl00007502
更新日期:2002-01-01 00:00:00
abstract:AIM:The present case report describes colon injury subsequent to uterine penetration which is associated with the use of an intrauterine device (IUD). CASE:A 29-year-old multiparous woman, who presented with vague abdominal pain, had a TCu 380A inserted at her postpartum third month visit. The T-shaped segment of the ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0716-2
更新日期:2009-03-01 00:00:00
abstract::In the previous decade, the prevalence of HBs-Ag positivity and the anti-HCV positivity declined in Turkey. We aimed to investigate the prevalences of HBs Ag and anti-HCV positivity in pregnant women in Ankara, the capital city of Turkey, while the vertical transmission should be important way of HBV and HCV transmiss...
journal_title:Archives of gynecology and obstetrics
pub_type: 信件
doi:10.1007/s00404-009-1145-6
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to investigate differential expression of the cell cycle signaling proteins p27 and Jun activation domain-binding protein 1 (Jab1) in benign ovarian cysts of patients with endometriosis compared to controls. METHODS:Ovarian tissues of 26 endometriosis and 28 non-endometriosis patie...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-015-3642-0
更新日期:2015-08-01 00:00:00
abstract::Early detection and repair of bladder perforation reduce postoperative morbidity. We describe two cases of bladder perforation sustained during complicated laparoscopic adhesiolysis and discuss a previously reported simple method of detecting bladder trauma during operative laparoscopy. ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0413-6
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To explore the psycho-social impact of vesico-vaginal fistula (VVF) on women in Niger. STUDY DESIGN:We conducted a qualitative study on 21 women in convalescence at the DIMOL Reproductive Health Center in Niamey, Niger, in 2008 and 2009. The women had undergone 1-3 fistula repair operations and all had stillbo...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1652-5
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Despite safety concerns, β2-sympathomimetics are still widely used as tocolytic agents. β-Blockers in turn are used to treat vasculo-proliferative diseases of the newborn such as retinopathy of prematurity (ROP), which may lead to visual impairment and blindness. The scope of this study was to investigate wheth...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-020-05463-z
更新日期:2020-03-01 00:00:00
abstract:INTRODUCTION:Craniosynostosis is a condition characterized by a premature closure of one or more skull sutures and refers to a wide spectrum of cranial malformation with an estimated birth of 1:2,000-1:4,000 live births. Four receptors (FGFR 1, FGFR 2, FGFR 3, FGFR 4) involving mutation in the fibroblast growth factor ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-010-1643-6
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effectiveness of Metformin on ovulation and eventual clinical pregnancy in different phenotypes of polycystic ovary syndrome (PCOS). MATERIALS AND METHODS:A total of 359 subjects who had proven PCOS according to Rotterdam criteria were prospectively selected. Patien...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-013-2800-5
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To determine a predictive model for supporting decisions relating to the prognosis for women presenting with preterm labor and intact membranes. METHOD:We conducted a prospective observational cohort study on 70 pregnant women at between 22 and 34 weeks of gestation. Transvaginal sonographic evaluation on the ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-012-2397-0
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To assess the main neonatal morbidity results in relation to induced labour indications. METHODS:Historical groups from a total of 3,817 deliveries over a three year period (2009, 2010 and 2011) in "Mancha-Centro" Hospital (Alcázar de San Juan) formed the study group. All programmed and non-avoidable caesarean...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3349-7
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:A previous decision analysis models for two strategic choices for trial of labor or repeated cesarean after prior cesarean concluded that the degree of wish for an additional future pregnancy appeared to be a major determinant for choice between the two strategic options. We had extended the analysis model to...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0373-x
更新日期:2007-11-01 00:00:00