Abstract：
BACKGROUND:The aim of this study was to evaluate the effectiveness of Metformin on ovulation and eventual clinical pregnancy in different phenotypes of polycystic ovary syndrome (PCOS). MATERIALS AND METHODS:A total of 359 subjects who had proven PCOS according to Rotterdam criteria were prospectively selected. Patients' PCOS phenotypes were determined and recorded. All patients were younger than 35 years. Clinical and biochemical assays in all patients were initially obtained. Then patients were divided into two separate groups. One group received both 1,500 mg of Metformin and 1 mg of folic acid per day and the other group received only 1 mg of folic acid for a total of 2 months. Subsequently, all patients underwent ovulation stimulation with 5 mg of Letrozole per day for 5 days followed by an intra-uterine insemination. Finally, ovulation and pregnancy rates were evaluated for all four PCOS phenotypes. Effect of Metformin therapy was evaluated for each group and each phenotype. RESULTS:The pregnancy rate in Metformin and non-Metformin groups were, respectively, as follows: in phenotype A (39.2 vs. 33.7 %, p = 0.270), phenotype B (43.8 vs. 20 %, p = 0.210), phenotype C (44 vs. 20 %, p = 0.064), and phenotype D (36.5 vs. 28.6 %, p = 0.279). CONCLUSION:Although there was a little improvement in ovulation and pregnancy rates among patients with B and C phenotypes, there was not a statistically significant difference between the two groups. Based on our study, Metformin therapy does not change the ovulation and pregnancy rate.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Hosseini MA,Alleyassin A,Sarvi F,Safdarian L,Kokab A,Fanisalek Mdoi
10.1007/s00404-013-2800-5subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1131-6issue
5eissn
0932-0067issn
1432-0711journal_volume
288pub_type
杂志文章,随机对照试验abstract：OBJECTIVES:Cervical cancer is the most common malignant tumor in female reproductive tract and primarily metastasizes through the lymphatic system that will affect prognosis of patients. Maspin, a member of the serine protease inhibitors (serpins) super family, has recently been indicated as a tumor suppressor in many ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-013-2988-4
更新日期：2014-02-01 00:00:00
abstract：:In the previous decade, the prevalence of HBs-Ag positivity and the anti-HCV positivity declined in Turkey. We aimed to investigate the prevalences of HBs Ag and anti-HCV positivity in pregnant women in Ankara, the capital city of Turkey, while the vertical transmission should be important way of HBV and HCV transmiss...
journal_title：Archives of gynecology and obstetrics
pub_type： 信件
doi：10.1007/s00404-009-1145-6
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:The unacceptable multiple gestation rate currently associated with in vitro fertilization (IVF) would be substantially alleviated if the routine practice of transferring more than one embryo were reconsidered. While transferring a single embryo is an effective method to reduce the clinical problem of multiple g...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-012-2396-1
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:The role of cervical cerclage to prevent preterm birth (PTB) remains controversial. The aim of this study was to identify prognostic factors for cerclage failure among singleton pregnant women following prophylactic cerclage (PC). METHODS:A retrospective analysis of PC was performed in a single center. The mai...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-017-4600-9
更新日期：2018-02-01 00:00:00
abstract：:Association of pregnancy with esophageal cancer is an extremely rare event. The symptoms are frequently masked by factors related to normal pregnancy and diagnostic approaches are restricted by physical and psychological clinical events. Hence, the cancer stage is usually advanced at the time of diagnosis. The approac...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0724-2
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:There are many studies documenting increased prevalence of periodontal infection in women with preeclampsia. But, very few studies have attempted to establish causal relationship between the two. OBJECTIVE:To find out causal circumstantial evidence by isolating specific periodontal pathogens in oral and pla...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-011-2012-9
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder in reproductive-age women. It is indeed a multifactorial condition evidenced by ovarian dysfunction, hyperandrogenaemia, infertility, hormonal imbalance and chronic anovulation. Experimental evidence infers that PCOS women are prone ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,评审
doi：10.1007/s00404-020-05951-2
更新日期：2021-01-13 00:00:00
abstract：INTRODUCTION:Laparoscopic-assisted myomectomy (LAM) is a minimally invasive procedure with many advantages. However, progressive formation of uterine arteriovenous fistula (AVF) after LAM is not described as a significant complication. CASE REPORT:A 39-year-old nulligravida underwent LAM for multiple myomas. On ultras...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-0981-8
更新日期：2009-10-01 00:00:00
abstract：AIMS:Postoperative seroma is the most frequent sequelae after mastectomy and axillary surgery with no optimal regimens for seroma resolution recommended in routine clinical. Indwelling cannulas with needle and catheter have been widely used in long-term medication therapies, but evidence of indwelling cannulas in serom...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-019-05396-2
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:Studies on the influence of CO₂ pneumoperitoneum on the abdominal cavity during robotic procedures are lacking. This is the first study to evaluate surgical field modifications related to CO₂ pressure, during laparoscopic and robotic surgery. METHODS:Consecutive patients scheduled for laparoscopic or robotic h...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3494-z
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:To analyze the effect of Chlamydia trachomatis (C. trachomatis) on adverse pregnancy outcomes based on the currently available evidence. METHODS:Multiple databases were comprehensively searched from the available date of inception through December 9, 2019. The effect of C. trachomatis on adverse pregnancy outc...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00404-020-05664-6
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To evaluate the role of Helicobacter pylori (H. pylori) in the pathogenesis of hyperemesis gravidarum (HG) and the value of adding a non teratogenic regimen for its treatment in intractable cases. METHODS:Eighty hyperemesis gravidarum cases were recruited from Ain Shams University out patient clinics. A comple...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-010-1759-8
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:The present study aimed to assess the risk of obstetric anal sphincter injuries (OASIS) of a subsequent delivery after the previous OASIS in countries with low (Finland) and high rates (Norway and Sweden) of OASIS. METHODS:This population-based case-control study included women who experienced OASIS 1997-2002....
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05550-1
更新日期：2020-06-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 已发布勘误
doi：10.1007/s00404-019-05279-6
更新日期：2019-10-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0634-3
更新日期：2009-01-01 00:00:00
abstract：METHODS:We describe a prospective study, done over a 2-year period in which a total of 958 women having a vaginal delivery were randomised to the drainage method (478 women) or controlled cord traction method (480 women) for placental delivery. RESULTS:The mean age, parity, gestation and birth weight were similar in t...
journal_title：Archives of gynecology and obstetrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00404-004-0619-9
更新日期：2005-04-01 00:00:00
abstract：:Unicornuate uterus with a rudimentary horn is a rare müllerian anomaly. We report a case of a unicornuate uterus with adenomyosis in a laterally dislocated rudimentary horn, which showed a functioning endometrial islands, with associated ipsilateral agenesis of the kidney. ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s004049900045
更新日期：2000-09-01 00:00:00
abstract：:We report a case of acute disseminated intravascular coagulation (DIC) developed during menstruation in an adenomyosis patient. No known predisposing factor for DIC such as infection or pregnancy was involved in this case. As anticoagulation therapy and supplementation of coagulation factors quickly improve the state,...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s004040100243
更新日期：2002-12-01 00:00:00
abstract：AIMS AND OBJECTIVES:To compare the three techniques of hysterectomy-total laparoscopic hysterectomy (TLH), laparoscopic assisted vaginal hysterectomy (LAVH) and non-descent vaginal hysterectomy (NDVH). MATERIALS AND METHODS:Ninety women with benign disease of uterus with failed medical management or not amenable to me...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-010-1778-5
更新日期：2011-10-01 00:00:00
abstract：:Renal cell carcinoma is a rare, potentially fatal tumor that occasionally occurs during pregnancy. The probability of cure is directly related to the stage or degree of tumor dissemination. Surgical resection is the mainstay of treatment of this disease. A case of patient who was diagnosed with a renal mass in the sec...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0455-9
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:To compare the effectiveness of cervical ripening by a mechanical method (double-balloon catheter) and a pharmacological method (prostaglandins) in women with one previous cesarean delivery, an unfavorable cervix (Bishop score < 6), and a singleton fetus in cephalic presentation. METHODS:This retrospective stu...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-020-05473-x
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:The Cancer Genome Atlas (TCGA) identified four prognostic subgroups of endometrial carcinoma: copy-number-low/p53-wild-type (p53wt), POLE-mutated/ultramutated (POLEmt), microsatellite-instability/hypermutated (MSI), and copy-number-high/p53-mutated (p53mt). However, it is still unclear if they may be integra...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,meta分析
doi：10.1007/s00404-020-05542-1
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Both cigarette smoking and alcohol consumption are somehow implicated in sperm function, but the impact of these two lifestyle factors on sperm parameters remains controversial. The present study is focused on the impact of cigarette smoking and alcohol consumption separately and combined on sperm parameters an...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-014-3281-x
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:Human papillomavirus (HPV) can cause condylomata acuminata, also known as genital warts. Our aim was to evaluate the long-term recurrence of genital warts after primary carbon dioxide laser treatment before the introduction of the vaccination against HPV. METHODS:Recurrence rate and localization of genital war...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05242-5
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To diagnose polycystic ovary syndrome (PCOS) in young infertile women using different diagnostic criteria. To define serum anti-Müllerian hormone (AMH) cutoff values for PCOS definition. To investigate the correlation between AMH and body mass index (BMI). METHODS:Retrospective case-control study. A total of 1...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-018-4803-8
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Zollinger Ellison syndrome (ZES), an ulcerative disease of the upper gastrointestinal tract that involves the production of high levels of gastrin and gastric acid, is a rare, symptomatic, endocrine neoplastic disease. CASE:We report a rare case of gastrinoma that was first diagnosed during pregnancy in whi...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-007-0319-3
更新日期：2007-08-01 00:00:00
abstract：PURPOSE:To assess the efficacy and safety of an intravenous formulation of tranexamic acid to reduce intrapartum and postpartum bleeding in patients giving birth by cesarean section. METHODS:Healthy women with normal pregnancies, at any gestational age, that we performed ceaserean section. Two hundred and twenty-three...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00404-012-2624-8
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To assess adverse pregnancy outcomes in patients complicated with mild or severe Hyperemesis Gravidarum (HG). METHODS:A retrospective cohort study of women aged 18-45 with a singleton pregnancy that were admitted to the gynecological ward at the Soroka University Medical Center due to HG between the years 2013...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05192-y
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the neovascularization in placental polyp tissue by computed tomographic angiography and to determine the need for uterine artery embolization before hysteroscopic resection. STUDY DESIGN:Seventeen consecutive women with suspected placental polyp were enrolled in this retrospective study. Neovasc...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-009-1161-6
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To determine the accuracy of clinical criteria relative to Nugent's criteria for diagnosing bacterial vaginosis (BV) in the pregnant patient. METHODS:This prospective study was conducted in pregnant patients requiring a speculum examination in an ER triage system. Determination was made of vaginal pH, whiff ...
journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-008-0766-5
更新日期：2009-04-01 00:00:00
