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Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update.

Abstract：

BACKGROUND:Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder in reproductive-age women. It is indeed a multifactorial condition evidenced by ovarian dysfunction, hyperandrogenaemia, infertility, hormonal imbalance and chronic anovulation. Experimental evidence infers that PCOS women are prone to cardiovascular problems and insulin resistance. PURPOSE:To furnish the details about the association of inflammatory markers in PCOS. DESIGN:An extensive literature search on PubMed, science direct and google scholar has been performed for articles about PCOS and inflammation in PCOS. A comprehensive analysis using original articles, reviews, systemic and meta-analysis was conducted for better understanding the relationship between inflammatory cytokines and PCOS. RESULTS:The inflammatory markers perform a substantial part in managing the functions of the ovary. Any disturbances in their levels can lead to ovarian dysfunction. Inflammatory markers are associated with PCOS pathogenesis. The interplay between inflammatory cytokines in the PCOS ovary strongly implies that inflammation is one of the most potent risk factors of PCOS. CONCLUSION:Inflammatory markers have a significant role in regulating the ovary. This manuscript highlights the significance of metabolic and inflammatory markers with PCOS. Since PCOS is always considered as a metabolic disorder, researchers can also consider focusing on the relationship between the inflammatory markers in PCOS to establish a new treatment or management of the disease and to improve women's health.

journal_name

Arch Gynecol Obstet

journal_title

Archives of gynecology and obstetrics

authors

Abraham Gnanadass S,Divakar Prabhu Y,Valsala Gopalakrishnan A

doi

10.1007/s00404-020-05951-2

subject

Has Abstract

pub_date

2021-01-13 00:00:00

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-020-05951-2

pub_type

杂志文章,评审

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