Influence of donor and host age on the regeneration and blood flow of splenic transplants.

Abstract:

:After splenectomy there is an increased risk of fatal overwhelming postsplenectomy sepsis, especially in children. If all alternatives to splenectomy fail, autotransplantation of splenic fragments is indicated. These fragments regenerate after a necrotic phase to small splenic nodules. Regulatory factors governing the regeneration process are largely unknown. Inbred rats were used as a model to define the influence of recipient and donor age on the regenerated mass and the blood flow of transplanted splenic fragments. These are both important factors for the protective function of the spleen. Fetal, newborn, weanling, or adult spleens were implanted into the greater omentum of newborn, weanling, or adult rats. The younger the recipient and donor, the better the regeneration and perfusion of transplants. However, these did not reach more than 40% of the normal splenic mass. In addition, no experimental group achieved more than one third of the normal splenic blood flow. There is an obvious age dependency in splenic regeneration and blood flow, but the transplants are far from attaining a normal splenic mass and perfusion.

journal_name

J Pediatr Surg

authors

Westermann J,Willführ KU,Pabst R

doi

10.1016/s0022-3468(88)80234-3

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

835-8

issue

9

eissn

0022-3468

issn

1531-5037

pii

S002234688800274X

journal_volume

23

pub_type

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