Cannulating the contraindicated: effect of low birth weight on mortality in neonates with congenital diaphragmatic hernia on extracorporeal membrane oxygenation.

Abstract:

BACKGROUND/PURPOSE:Restrictions for ECMO in neonates include birth weight less than 2kg (BW <2kg) and/or gestational age less than 34weeks (GA <34weeks). We sought to describe their relationship on mortality. METHODS:Neonates with a primary diagnosis code of CDH were identified in the Extracorporeal Life Support Organization (ELSO) registry, and logistic regression models were used to examine the effect of BW <2kg and GA <34weeks on mortality. RESULTS:We identified 7564 neonates with CDH. The overall mortality was 50%. There was a significantly higher risk of death with unadjusted odds ratio (OR) 2.39 (95% confidence interval [CI]: 1.53-3.74; P<0.01) for BW <2kg neonates. The adjusted OR of death for BW <2kg neonates remained significantly high with over two-fold increase in the odds of mortality when adjusted for potential confounding variables (OR 2.11, 95% CI: 1.30-3.43; P<0.01). However, no difference in mortality was observed in neonates with GA <34weeks. CONCLUSIONS:While mortality among CDH neonates with a BW <2kg was substantially increased, GA <34weeks was not significantly associated with mortality. Effort should be made to identify the best candidates for ECMO in this high-risk group and develop treatment strategies to optimize their survival. TYPE OF STUDY:Case-Control Study, Retrospective Comparative Study. LEVEL OF EVIDENCE:Level III.

journal_name

J Pediatr Surg

authors

Delaplain PT,Zhang L,Chen Y,Nguyen DV,Di Nardo M,Cleary JP,Yu PT,Guner YS

doi

10.1016/j.jpedsurg.2017.08.037

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

2018-2025

issue

12

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(17)30534-1

journal_volume

52

pub_type

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