Castleman's disease in children.

Abstract:

:A three and one-half-year-old girl and a 12-year-old boy presented with features of the two clinical presentations of Castleman's disease or giant lymph node hyperplasia. The girl presented with anemia, fever, night sweats, hypergammaglobulinemia, and a palpable abdominal mass. Her symptoms were consistent with those seen in the plasma-cell type of this disease. The boy presented with acute appendicitis and a left hilar mass was noted on his chest radiograph. His asymptomatic presentation was typical of the hyaline-vascular form. Both patients are well without evidence of recurrence four years following resection. Castleman's disease is a benign disorder of lymph nodes that occurs rarely in children. Since the original report in 1954 we could find only 18 cases in the 16-year and younger age group and our patient with the symptomatic form represents the youngest patient reported in the English literature. The management requires surgical resection of the enlarged nodes both for diagnosis and therapy since the enlarged nodes can mimic malignant tumors of the lymphoid system. No recurrences have been reported in pediatric patients.

journal_name

J Pediatr Surg

authors

Powell RW,Lightsey AL,Thomas WJ,Marsh WL

doi

10.1016/s0022-3468(86)80385-2

subject

Has Abstract

pub_date

1986-08-01 00:00:00

pages

678-82

issue

8

eissn

0022-3468

issn

1531-5037

pii

S002234688600249X

journal_volume

21

pub_type

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