Long-term follow-up of patients with high-risk congenital diaphragmatic hernia.

Abstract:

BACKGROUND/PURPOSE:Recent advances including prenatal diagnosis, high-frequency oscillatory ventilation, and nitric oxide inhalation therapy have gradually improved the survival of high-risk congenital diaphragmatic hernia. However, the factors affecting the long-term outcome of these patients have not been well established. METHODS:Thirty-three children with ages 4.1 +/- 2.5 years underwent clinical examination including growth measurements, echocardiography, ventilation, and perfusion scintigraphy. RESULTS:No late death was observed. Common complications were frequent respiratory tract infection (13 patients) and bowel obstruction (5 patients underwent surgery). Although frequent respiratory tract infection decreased with increasing age, patients with frequent respiratory tract infection had a decreased uptake of lung ventilation and perfusion scintigraphy on the affected side and had a decreased height for age and weight for height. No significant difference in lung ventilation and perfusion scintigraphy was observed between patients treated with and without extracorporeal membrane oxygenation, those requiring oxygen more than 1 month, and between those with and without prenatal diagnosis. Patients with a patch repair had decreased uptake on lung perfusion scintigraphy. Although frequent respiratory tract infection may be owing to hypoplasia of the ipsilateral lung, it may impair recovery of the hypoplastic lung. CONCLUSION:These results indicate that monitoring for respiratory tract infection in addition to nutritional assessment should be required in the follow-up of patients with congenital diaphragmatic hernia at high risk.

journal_name

J Pediatr Surg

authors

Kamata S,Usui N,Kamiyama M,Tazuke Y,Nose K,Sawai T,Fukuzawa M

doi

10.1016/j.jpedsurg.2005.08.022

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1833-8

issue

12

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(05)00679-2

journal_volume

40

pub_type

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