Choledochopancreatic elongated common channel disorders.

Abstract:

:A choledochopancreatic end-to-side ductal anastomosis was successfully performed in 40 puppies as an experimental animal model of choledochopancreatic elongated common channel disorders. Follow-up periods were up to 1 year after surgery. Fusiform dilatation was developed in all puppies. The dilatation was completed within 1 week after surgery and did not increase its size after that. Also, all puppies developed pancreatic juice reflux into the bile duct. As for the etiology of the dilatation of the bile duct, temporary stricture of anastomosis was a more important factor than the pancreatic juice reflux in our models. In the biliopancreatic juice, we found no significant change of bile acid analysis between the control and our operated puppies, but almost all pancreatic enzyme activities were elevated. Bile acid was considered to play an important role in the activation of pancreatic enzymes. Epithelial hyperplasia was the only significant pathological change in the bile duct wall. Definite chronic pancreatitis developed in one puppy 16 months after surgery and was considered to be caused by the reflux of bile into the pancreatic duct. The action of biliopancreatic juice to both the bile duct and to the pancreas was mild and chronic.

journal_name

J Pediatr Surg

authors

Miyano T,Suruga K,Shimomura H,Nittono H,Yamashiro Y,Matsumoto M

doi

10.1016/s0022-3468(84)80439-x

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

165-70

issue

2

eissn

0022-3468

issn

1531-5037

pii

S002234688400035X

journal_volume

19

pub_type

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