Tissue expander stimulated lengthening of arteries (TESLA) induces early endothelial cell proliferation in a novel rodent model.


BACKGROUND:We examine the mechanism of aortic lengthening in a novel rodent model of tissue expander stimulated lengthening of arteries (TESLA). METHODS:A rat model of TESLA was examined with a single stretch stimulus applied at the time of tissue expander insertion with evaluation of the aorta at 2, 4 and 7day time points. Measurements as well as histology and proliferation assays were performed and compared to sham controls. RESULTS:The aortic length was increased at all time points without histologic signs of tissue injury. Nuclear density remained unchanged despite the increase in length suggesting cellular hyperplasia. Cellular proliferation was confirmed in endothelial cell layer by Ki-67 stain. CONCLUSIONS:Aortic lengthening may be achieved using TESLA. The increase in aortic length can be achieved without tissue injury and results at least partially from cellular hyperplasia. Further studies are required to define the mechanisms involved in the growth of arteries under increased longitudinal stress.


J Pediatr Surg


Potanos K,Fullington N,Cauley R,Purcell P,Zurakowski D,Fishman S,Vakili K,Kim HB




Has Abstract


2016-04-01 00:00:00














  • Using a multidisciplinary and evidence-based approach to decrease undertriage and overtriage of pediatric trauma patients.

    abstract:BACKGROUND:The American College of Surgeons Committee on Trauma (ACS-COT) view over- and undertriage rates based on trauma team activation (TTA) criteria as surrogate markers for quality trauma patient care. Undertriage occurs when classifying patients as not needing a TTA when they do. Over-triage occurs when a TTA is...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章


    authors: Escobar MA Jr,Morris CJ

    更新日期:2016-09-01 00:00:00

  • Hypocalcemia and hyperphosphatemia after phosphate enema use in a child.

    abstract::The authors present a 3-year-old girl in whom severe hyperphosphatemia and hypocalcemia developed after the administration of three adult-sized hypertonic phosphate enemas. The commonly held notion that these enemas are not absorbed and therefore are systemically inactive is incorrect. With early intervention and trea...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Helikson MA,Parham WA,Tobias JD

    更新日期:1997-08-01 00:00:00

  • Fibrobronchoscopic treatment of foreign body aspiration in children: an experience of 5 years in Hangzhou City, China.

    abstract:OBJECTIVE:The aims of the study were to evaluate duration of symptoms, clinical manifestation, radiological findings, fibrobronchoscopic findings, and the complications of airway foreign body (FB). METHODS:A retrospective review of 304 children who had airway FB removed via fibrobronchoscopy from January 1997 to June ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tang FL,Chen MZ,Du ZL,Zou CC,Zhao YZ

    更新日期:2006-01-01 00:00:00

  • Multimodal anesthesia with the addition of methadone is superior to epidural analgesia: A retrospective comparison of intraoperative anesthetic techniques and pain management for 124 pediatric patients undergoing the Nuss procedure.

    abstract:BACKGROUND:The Nuss procedure corrects pectus excavatum by forceful displacement of the sternum with metal bars. Optimal pain management remains a challenge. Mutimodal anesthesia alleviates pain through blockade of multiple nociceptive and inflammatory pain receptors. METHODS:A retrospective chart review of anesthetic...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Singhal NR,Jones J,Semenova J,Williamson A,McCollum K,Tong D,Jerman J,Notrica DM,Nguyen H

    更新日期:2016-04-01 00:00:00

  • Delayed abdominal closure after congenital diaphragmatic hernia repair.

    abstract:PURPOSE:We present our experience with CDH patients who required delayed abdominal closure following CDH repair. METHODS:A retrospective review of all CDH repairs from 2004 to 2014 was performed. RESULTS:233 patients underwent CDH repair, of which 21 required delayed abdominal closure defined as the inability to clos...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Laje P,Hedrick HL,Flake AW,Adzick NS,Peranteau WH

    更新日期:2016-02-01 00:00:00

  • A bacteriologic basis for the evolution and severity of empyema.

    abstract::The management of pediatric empyema remains controversial. An experimental study was undertaken to evaluate the role of bacteria in the evolution and severity of empyema, using specific bacteria that are pathogens of empyema in children. A rabbit model was used. The groups were Haemophilus influenzae (n = 9), Bacteroi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bhattacharyya N,Umland ET,Kosloske AM

    更新日期:1994-05-01 00:00:00

  • Gaucher disease: fate of the splenic remnant after partial splenectomy--a case of rapid enlargement.

    abstract::In Gaucher disease, partial splenectomy has been suggested for alleviating the complications of splenomegaly as well as for avoiding the immunologic compromise and potential acceleration of bony and hepatic involvement that may follow total splenic resection. However, the fate of the splenic remnant has been reported ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Fleshner PR,Astion DJ,Ludman MD,Aufses AH Jr,Grabowski GA,Dolgin SE

    更新日期:1989-06-01 00:00:00

  • The impact of transfer on pediatric trauma outcomes.

    abstract:BACKGROUND:Recently, concerns have been raised over delays that result from transferring patients to designated trauma centers. This study aimed to assess whether transfer status had an impact on pediatric trauma outcomes. METHODS:Using a local 1996-2014 pediatric trauma database containing 1541 patients, the followin...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Locke T,Rekman J,Brennan M,Nasr A

    更新日期:2016-05-01 00:00:00

  • Fetal response to neutral gas and liquid media for intraamniotic distension.

    abstract:PURPOSE:This study was aimed at comparing the effects of a neutral liquid and a neutral gas used as intraamniotic media on umbilical blood flow, O2 delivery, blood pressure, acid-base status, and electrolytes in the fetus at escalating intraamniotic pressures. METHODS:Eight fetal lambs underwent invasive monitoring of...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Fauza DO,Rawn J,Fishman SJ

    更新日期:1999-04-01 00:00:00

  • Fetal tissue engineering: chest wall reconstruction.

    abstract:BACKGROUND/PURPOSE:This study was aimed at applying fetal tissue engineering to chest wall reconstruction. METHODS:Fetal lambs underwent harvest of elastic and hyaline cartilage specimens. Once expanded in vitro, fetal chondrocytes were seeded onto synthetic scaffolds, which then were placed in a bioreactor. After bir...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Fuchs JR,Terada S,Hannouche D,Ochoa ER,Vacanti JP,Fauza DO

    更新日期:2003-08-01 00:00:00

  • High-frequency ventilation at rates of 375 to 1800 cycles per minute in four neonates with congenital diaphragmatic hernia.

    abstract::Neonates with congenital diaphragmatic hernias (CDH) often die because of pulmonary hypoplasia and high pulmonary vascular resistance (PVR). Pulmonary hypertension and right-to-left shunting precedes progressive hypoxia and death. PVR is increased by acidosis and by high airway pressures. High-frequency oscillation (H...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Karl SR,Ballantine TV,Snider MT

    更新日期:1983-12-01 00:00:00

  • Wide gap esophageal atresia: a new method to elongate the upper pouch.

    abstract::A new surgical method is presented for overbridging wide gap esophageal atresia. The method is based on the fact that the atretic upper pouch has an excellent longitudinal blood supply, and is two to three times wider than the lower pouch. Muco-muscular flap is created, which is anastomosed to the lower esophagus. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Bar-Maor JA,Shoshany G,Sweed Y

    更新日期:1989-09-01 00:00:00

  • Perioperative circulating blood volume analysis in management of a 13-year-old female patient with an extraadrenal pheochromocytoma and refractory ventricular tachycardia: a case report.

    abstract::This report describes the use of discrete real-time monitoring of blood volume (BV) and cardiac index (CI) by a dye densitography analyzer before, during, and after removal of a pheochromocytoma. The BV expanded by about 1.1 L and CI increased by about 2.2-fold after the tumor was removed. In lieu of a rapid catechola...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Iijima T,Iwao Y,Ito Y

    更新日期:2006-08-01 00:00:00

  • Predictability model of the need for extracorporeal membrane oxygenation in neonates with meconium aspiration syndrome treated with inhaled nitric oxide.

    abstract:BACKGROUND:As the use of inhaled nitric oxide (iNO) resulted in a decline in the need for extracorporeal membrane oxygenation (ECMO) in neonates with hypoxic respiratory failure, iNO has become an accepted treatment modality even in non-ECMO centers. However, because not all neonates respond to iNO, the timely identifi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Friedlich P,Noori S,Stein J,Shin C,Burns C,Ramanathan R,Seri I

    更新日期:2005-07-01 00:00:00

  • Gastrointestinal ramifications of the cloacal exstrophy complex: a 44-year experience.

    abstract:PURPOSE:Cloacal exstrophy is a rare and complex congenital anomaly requiring coordination among multiple pediatric subspecialties. There is currently no consensus regarding the fate and function of the hindgut, which plays an integral role in patients' long-term gastrointestinal health and genitourinary reconstruction....

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Sawaya D,Goldstein S,Seetharamaiah R,Suson K,Nabaweesi R,Colombani P,Gearhart J

    更新日期:2010-01-01 00:00:00

  • Restored immune response to an MHC-II-Restricted antigen in tumor-bearing hosts after elimination of regulatory T cells.

    abstract:BACKGROUND/PURPOSE:Pediatric sarcomas have a poor prognosis, recur frequently, and are not effectively treated by currently available therapy. Immunotherapy is a promising treatment modality; however, to be successful, immune tolerance must be overcome. CD4+CD25+ T cells are immunosuppressive. The authors hypothesize t...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Nicholl M,Lodge A,Brown I,Sugg SL,Shilyansky J

    更新日期:2004-06-01 00:00:00

  • Percutaneous inferior vena cava placement of tunneled silastic catheters for prolonged vascular access in infants.

    abstract::In infants and children requiring prolonged and multiple central venous catheterizations, conventional cannulation sites may become thrombosed or stenotic, making inability to gain vascular access a life-threatening problem. The technique we use for the percutaneous placement of inferior vena caval tunneled silastic c...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Robertson LJ,Jaques PF,Mauro MA,Azizkhan RG,Robards J

    更新日期:1990-06-01 00:00:00

  • Cannulating the contraindicated: effect of low birth weight on mortality in neonates with congenital diaphragmatic hernia on extracorporeal membrane oxygenation.

    abstract:BACKGROUND/PURPOSE:Restrictions for ECMO in neonates include birth weight less than 2kg (BW <2kg) and/or gestational age less than 34weeks (GA <34weeks). We sought to describe their relationship on mortality. METHODS:Neonates with a primary diagnosis code of CDH were identified in the Extracorporeal Life Support Organ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Delaplain PT,Zhang L,Chen Y,Nguyen DV,Di Nardo M,Cleary JP,Yu PT,Guner YS

    更新日期:2017-12-01 00:00:00

  • Liver transplantation for biliary atresia associated with malignant hepatic tumors.

    abstract::The authors report 3 cases of liver transplantations in children between 4 and 10 years of age, complicated with malignant hepatic tumors after biliary atresia. The preoperative abdominal computed tomography (CT) scans of all 3 cases showed hepatic masses. The serum alpha-fetoprotein levels were elevated highly in 2 c...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Tatekawa Y,Asonuma K,Uemoto S,Inomata Y,Tanaka K

    更新日期:2001-03-01 00:00:00

  • Laparoscopic adjustable gastric banding in adolescents: Results at two years including psychosocial aspects.

    abstract:BACKGROUND/PURPOSE:Obesity now affects 3%-4% of the pediatric population and contributes to the increase in cardiac mortality in adulthood. Bariatric surgery is the best treatment for weight loss and the obesity-associated comorbidities in adults. We report here our experience of laparoscopic adjustable gastric banding...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章


    authors: Schmitt F,Riquin E,Beaumesnil M,Dinomais M,Topart P,Weil D,Malka J,Coutant R,Podevin G,Bouhours-Nouet N

    更新日期:2016-03-01 00:00:00

  • Allocation of resources and development of guidelines for extracorporeal membrane oxygenation (ECMO): Experience from a pediatric center in the epicenter of the COVID-19 pandemic.

    abstract::The rapid spread of coronavirus disease 2019 (COVID-19) has exceeded the standard capacity of many hospital systems and led to an unprecedented scarcity of resources, including the already limited resource of extracorporeal membrane oxygenation (ECMO). With the large amount of critically ill patients and the highly co...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审


    authors: Gerall C,Cheung EW,Klein-Cloud R,Kreines E,Brewer M,Middlesworth W

    更新日期:2020-12-01 00:00:00

  • In vivo measurement of intestinal absorption using 3-0 methylglucose in short bowel syndrome.

    abstract:PURPOSE:The management of patients with short bowel syndrome is complicated by the paucity of methods to assess in vivo the absorptive capacity of the remaining bowel. The purpose of this experiment was to assess the feasibility of using urinary recovery of 3-0 methylglucose (3-0 MG) as a quantitative measure of carboh...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Debru E,Martin GR,Sigalet DL

    更新日期:2001-05-01 00:00:00

  • Regional analgesia for postoperative pain in pediatric outpatient surgery.

    abstract::Of 156 children undergoing elective inguinal herniotomy under general anesthesia, 81 also had a regional nerve block using Bupivacaine. All were treated as outpatients and recovery was assessed by postanesthetic room nurses and by interrogating the parents as to the child's behavior at home. It was concluded that the ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Shandling B,Steward DJ

    更新日期:1980-08-01 00:00:00

  • Juvenile polyp in esophageal colon interposition.

    abstract::Esophageal polyps are rare in children, whereas colorectal juvenile polyps are common. An 11-year-old boy with an esophageal colonic interposition for an esophageal stricture secondary to caustic injury was found to have a polypoid mass in the interposed colon. Fiberoptic endoscopic removal with diathermy was performe...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Del Rosario MA,Croffie JM,Rescorla FJ,Hartman GE

    更新日期:1998-09-01 00:00:00

  • Paratesticular neuroblastoma with N-myc activation.

    abstract::The authors describe a case of disseminated neuroblastoma discovered as a paratesticular tumor in a 7-month-old boy. The ectopic adrenal tissues adjacent to the paratesticular tumor and multiple lesions in the adrenal gland and skin suggested the possibility of multifocal primary tumors. Although infantile neuroblasto...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Matsunaga T,Takahashi H,Ohnuma N,Tanabe M,Yoshida H,Enomoto H,Horie H,Shirasawa H,Simizu B

    更新日期:1993-12-01 00:00:00

  • Bleeding gastric ulcer in a newborn infant diagnosed by transumbilical aortography.

    abstract::Transumbilical aortography has been utilized for the first time to diagnose the cause of massive upper gastrointestinal hemorrhage in a newborn infant. We consider it a safe and accurate method in cases that meet the following criteria: massive hemorrhage uncontrollable by blood transfusions and supportive medical the...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Fliegel CP,Herzog B,Signer E,Nars P

    更新日期:1977-08-01 00:00:00

  • The 're-do' chest wall deformity correction.

    abstract:BACKGROUND:A small percentage of patients who undergo surgical correction of a chest wall deformity will have results so unsatisfactory that a second procedure, the so-called "re-do," will be required. CONCLUSIONS:The literature contains very little information regarding the technique and results of these procedures. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Ellis DG,Snyder CL,Mann CM

    更新日期:1997-09-01 00:00:00

  • Oral cholestyramine and paregoric therapy for intractable diarrhea following surgical correction of catastrophic disease of the GI tract in neonates.

    abstract::Ten surgical neonates with postoperative intractable diarrhea and secondary weight loss were treated with combination cholestyramine and paregoric therapy. Within 3-5 days all infants except two showed significant clinical improvement with a decreasing number of stools, an increase in the consistency of the stool, and...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Nagaraj HS,Cook L,Canty TG,Haight G

    更新日期:1976-10-01 00:00:00

  • Preputial unfurling to correct the buried penis.

    abstract::Recognition of the buried penis is necessary both to ensure its proper management and to avoid performance of a standard circumcision, which can result in penile degloving. We describe a simple technique of unfurling the prepuce which provides adequate functional and cosmetic replacement for the penile shaft skin. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Donahoe PK,Keating MA

    更新日期:1986-12-01 00:00:00

  • Intermediate and long-term outcomes of a bowel management program for children with severe constipation or fecal incontinence.

    abstract:PURPOSE:We sought to examine the long-term clinical success rates of a bowel management program (BMP) for children with severe constipation or fecal incontinence. METHODS:A single center review was conducted of children (≤18 years) enrolled in a BMP and followed in a colorectal specialty clinic (2011-2017). All patien...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Kilpatrick JA,Zobell S,Leeflang EJ,Cao D,Mammen L,Rollins MD

    更新日期:2020-03-01 00:00:00