Influence of the type of operations on the development of latex sensitization in children with myelomeningocele.

Abstract:

BACKGROUND:A genetic tendency to develop latex IgE responses in children with spina bifida has been suggested, but their degree of exposure to latex as well as the route and chronology for sensitization can be different from those of other children with multiple surgeries. The aim was to study the influence of the type of operation on the development of latex sensitization in children with myelomeningocele. METHODS:In 90 children with myelomeningocele operated with latex, data were collected about age, sex, family, and personal history of allergy, serum total IgE, presence of a ventricular-peritoneal (v-p) shunt, and number and duration of operations, classified as urological, orthopedic, on the v-p shunt, other neurosurgical, and others. A multivariate logistic regression analysis was performed, using the presence of latex sensitization as dependent variable. RESULTS:Serum total IgE, the number of urological and of orthopedic operations were synergistic variables to predict latex sensitization, together with the presence of a v-p shunt, but not the number of operations performed on this device. This seems to play an adjuvant role in the process of sensitization. CONCLUSIONS:Not only the number, but also the type of operations, namely, of urological and orthopedic nature, is important in the development of latex sensitization in children with myelomeningocele.

journal_name

J Pediatr Surg

authors

Mazon A,Nieto A,Pamies R,Felix R,Linana JJ,Lanuza A,Caballero L,Estornell F,Garcia-Ibarra F,Alvarez-Garijo JA

doi

10.1016/j.jpedsurg.2005.01.009

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

688-92

issue

4

eissn

0022-3468

issn

1531-5037

pii

S0022346805000084

journal_volume

40

pub_type

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