Feasibility and safety of using low-body-weight donors in pediatric liver transplantation.

Abstract:

BACKGROUND:Donors with low-body-weight were previously reported to be related to inferior recipient outcomes in pediatric liver transplantation. However, the scarce availability of age and size-matched organs has encouraged us to re-evaluate the feasibility and safety of using low-body-weight donors. METHODS:We retrospectively analyzed 91 deceased donor pediatric liver transplantation between January 2014 and December 2016, donor weight less than 5 kg was defined as low-body-weight donors. The recipients were divided into two groups according to donor weight. (≤5 kg and 5 kg < to ≤20 kg). Donor and recipient characteristics, perioperative data, postoperative complications as well as graft and recipient survival rate were compared RESULTS: The recipients and grafts recovery after transplantation were comparable between two groups. The recipients receiving low-body-weight donors showed higher risk of hepatic artery thrombosis and small-for-size syndrome, however, these complications can effectively be treated by our strategies. The 2-year patient survival rates were 92.9% and 95.2%, 2-year graft survival rates were 92.9% and 93.7% in Groups 1 and 2, without significant difference. CONCLUSIONS:Our finding suggested that the utility of livers from low-body-weight donors is a potential strategy to increase donor availability in well-selected pediatric recipients. LEVEL OF EVIDENCE:III.

journal_name

J Pediatr Surg

authors

Song Z,Ma N,Dong C,Sun C,Meng X,Zhang W,Wang K,Wu B,Li S,Qin H,Han C,Li H,Gao W,Shen Z

doi

10.1016/j.jpedsurg.2019.04.023

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

2382-2386

issue

11

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(19)30324-0

journal_volume

54

pub_type

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