Abstract：
OBJECTIVE:Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants. METHODS:The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+. RESULTS:Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways. CONCLUSIONS:Results show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Akyol S,Akgun MY,Yetmez M,Hanci M,Oktar FN,Ben-Nissan Bdoi
10.1016/j.wneu.2020.08.016subject
Has Abstractpub_date
2020-12-01 00:00:00pages
e138-e148eissn
1878-8750issn
1878-8769pii
S1878-8750(20)31780-0journal_volume
144pub_type
杂志文章abstract：BACKGROUND:After showing the success of mechanical thrombectomy (MT) in treating large-vessel occlusion stroke, the target population has been expanded to include patients with smaller and more distal vessels including the M2 segment of the middle cerebral artery. We compared the procedural and clinical outcomes of pat...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.04.175
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Stenting may be a safer alternative to endarterectomy for treating carotid artery stenosis (CAS), but its long-term efficacy is uncertain. There is a lack of long-term and noncontrolled clinical trial data that reflects "real-world" CAS. This study aimed to analyze the long-term efficacy and safety of our ce...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.09.065
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The cervical spine may be used as a harvesting site of local autograft material during anterior cervical discectomy and fusion procedures. We analyzed the quality and composition of bone grafts obtained from different parts of the cervical vertebrae in a cadaveric model. METHODS:Five fresh adult human cadav...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.12.175
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:We sought to (1) describe psychological, physical, and cognitive functions in patients 10 years after intracranial aneurysm rupture and (2) identify any differences in outcome variables between age groups, gender or aneurysm locations. METHODS:A consecutive sample of patients (n=217) treated for intracranial...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2012.03.032
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:The blood-brain barrier (BBB) of patients with moyamoya angiopathy (MMA) is unstable, which may contribute to transient neurologic symptoms (TNS) after direct bypass surgery. However, BBB-related proteins have never been investigated. The purpose of this study was to evaluate the perioperative serum levels of...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.08.134
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Our objective was to analyze the relevance, potential prognostic factors, and complications of endoscopic third ventriculostomy (ETV) in patients with shunt failures. METHODS:Among 721 ETVs performed between 1999 and 2013, we studied 53 patients with shunts (31 men, 21 less than 18 years of age) who had an ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.01.058
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:To evaluate whether the postoperative neutrophil-to-lymphocyte ratio (NLR) is a prognostic marker for patients with intracerebral hemorrhage (ICH) undergoing surgical hematoma evacuation. METHODS:This retrospective cohort study was conducted to identify patients with ICH who underwent hematoma evacuation bet...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.10.154
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:Currently, radiologic predictors for the resectability of cervical dumbbell schwannomas remain unknown. To identify radiologic predictors for resectability, we retrospectively reviewed data from 72 patients. METHODS:From January 1995 to June 2017, 72 patients who underwent surgical treatment for cervical dum...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.09.186
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Verification of complete occlusion or resection of neurovascular lesions is often performed using intraoperative angiography. Surgery for spinal vascular lesions such as arteriovenous malformations (AVMs) and arteriovenous fistulas (AVFs) is typically performed with the patient in the prone position, making ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.01.208
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Stereotactic radiosurgery (SRS) as a treatment for cerebral cavernous malformation (CCM) has been controversial, but there are few pathological reports showing its long-term therapeutic effect, and literature reporting the CCM cyst formation after SRS is also rare. CASE DESCRIPTION:We present a 30-year-old ...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.07.042
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Anterior cervical diskectomy and fusion with plate-screw construct has been gradually applied for multilevel cervical spondylotic myelopathy in recent years. However, long cervical plate was associated with complications including breakage or loosening of plate and screws, trachea-esophageal injury, neurovas...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2017.05.045
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Moyamoya disease (MMD) is a chronic cerebrovascular disorder with little known etiology. We aim to propose a new classification system for MMD from the perspective of embryology. METHODS:MMD patients' digital subtraction angiograms were retrospectively analyzed. Every angiogram was analyzed to f...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.099
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:To avoid surgical site infections (SSIs) by identifying patients at high risk for infectious complications, a better understanding of relevant risk factors is required. This manuscript describes a matched case-control study of patients undergoing cranial neurosurgery with postoperative surgical site infectio...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2016.07.093
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:Several studies have looked for an association between radiologic findings and neurologic outcome after cervical trauma. In the current literature, there is a paucity of evidence proving the prognostic role of soft tissue damage or bony integrity. Our objective is to determine radiologic findings related to n...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.02.034
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:The present study examined the physical extent of Modic type 1 (MT1) changes and other phenotypic magnetic resonance imaging (MRI) findings in the vertebrae of patients with low back pain (LBP) and MT1 changes. We also identified any correlations of these findings with the severity of pain and the Oswestry Di...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.09.132
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:Tumors of the jugular foramen are notably rare, and the majority of them arise from the glomic tissue of the jugular vein. There are other tumors that do not originate from that tissue, and these are called the nonglomic tumors. This report includes a series of patients with nonglomic tumors of the jugular fo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.07.013
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:Primary orbitofrontal cholesterol granuloma (OFCG) is rare. We present 4 cases of OFCG and a systematic literature review to examine patient characteristics, presentation, treatment, and outcome. METHODOLOGY:Our institutional records were reviewed for OFCG cases. A systematic literature review was perform...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2015.11.095
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:Anatomy of the posterior ascending artery (PAA) has been well documented. The PAA forms an apical arcade, which supplies the small branches to the tip of the dens. However, morphometrics of this artery such as diameter and distance from the midline, which could be applied to the diagnosis and surgical procedu...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.118
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:Currently, no spinal classification system has achieved universal acceptance. Therefore, it is important to choose a reliable classification within clinical practice. The objective of this study was to determine and compare the intraobserver and interobserver agreement of the Load Sharing Classification (LSC)...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.138
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Invasive pituitary adenomas often recurred after postoperative radiotherapy and are difficult to treat. Temozolomide (TMZ) is an alkylating cytostaticum and has been reported to reduce pituitary tumor size and hormone hypersecretion, However, this is far from enough. Pituitary adenomas have relatively high e...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.12.174
更新日期：2019-01-10 00:00:00
abstract：OBJECTIVE:To report our experience of endoscopic disc removal by anterior approach for management of cervical myelopathy in 210 patients. METHODS:A retrospective study of 187 cases of single- and 23 cases of double-level disc disease was performed. Cases of myelopathy with or without unilateral or bilateral radiculopa...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.107
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Surgical treatment of meningiomas next to venous sinuses is difficult because of their irregular growth patterns and infiltration into the venous sinuses, making gross total resection impossible in some patients. We evaluated the postoperative clinical and neurologic course of this tumor subgroup. METHODS:T...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.025
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Intraneural ganglia are benign mucinous cystic formations that originate within the epineurium of peripheral nerves. Different treatments have been recommended, with an overall satisfactory outcome. In this paper, we aim to evaluate the long-term outcomes of surgical treatment of peroneal intraneural ganglia...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.195
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:Treatment of giant intracranial arteriovenous malformations (gAVMs) is a formidable challenge for neurosurgeons and carries significant morbidity and mortality rates for patients compared with smaller AVMs. In this study, we reviewed the treatments, angiographic results, and clinical outcomes in 64 patients w...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.07.051
更新日期：2015-12-01 00:00:00
abstract：:Neurotechnology is set to expand rapidly in the coming years as technological innovations in hardware and software are translated to the clinical setting. Given our unique access to patients with neurologic disorders, expertise with which to guide appropriate treatments, and technical skills to implant brain-machine i...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.11.028
更新日期：2020-11-13 00:00:00
abstract：BACKGROUND:Visual loss can be encountered in the immediate, early, or even delayed postoperative period after resection of skull base meningiomas involving the optic apparatus. Various mechanisms for visual loss can include mechanical injury, vascular insult, optic nerve and chiasm edema, and vasospasm of the blood sup...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.06.052
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:The origin of chronic subdural hematomas (CSDH) and the pathophysiology of its enlargement remain unknown. The chemical fluid composition of CSDH, the contribution of cerebrospinal fluid (CSF) to its enlargement, and the relationship to its appearance on computed tomography (CT) also are not entirely clear. ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.108
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:To adapt a study exploring the needs of neurosurgery patients in a tertiary care hospital in Canada to examine, for the first time, the perspectives of neurosurgery patients in a low-income country with limited health care resources. METHODS:Semistructured interviews were conducted with 25 neurosurgery patie...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.05.015
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To examine the influence of cerebral vasospasm on health-related quality of life after subarachnoid hemorrhage. An additional objective was to determine how the timing of nimodipine therapy can influence health-related quality of life. METHODS:Patients treated between 1998 and 2008 for nontraumatic subarachn...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2012.09.011
更新日期：2013-07-01 00:00:00
abstract：INTRODUCTION:Neurocutaneous melanosis (NCM) is a rare congenital syndrome. Except for some retrospective studies, information on clinical follow-up and management of these patients are limited. This study aimed to review our experience on diagnostic protocol and clinical follow-up of patients with NCM in a referral chi...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.11.091
更新日期：2020-11-24 00:00:00
