Abstract：
OBJECTIVE:The blood-brain barrier (BBB) of patients with moyamoya angiopathy (MMA) is unstable, which may contribute to transient neurologic symptoms (TNS) after direct bypass surgery. However, BBB-related proteins have never been investigated. The purpose of this study was to evaluate the perioperative serum levels of biomarkers representing BBB function in MMA patients based on the hypothesis that postoperative hemodynamic change may disrupt the BBB. METHODS:A total of 12 hemispheres in 11 patients with MMA were prospectively examined. Direct revascularization surgery was performed for all cases. The serum levels of tight junction (occludin and claudin 5), adherens junction (vascular endothelial-cadherin) proteins, and matrix metalloproteinase (MMP)-2 and MMP-9 were measured quantitatively 1 day before surgery and on postoperative days 1, 4, and 7. RESULTS:Successful patency of the direct bypass was achieved in all. The serum level of occludin was significantly increased on postoperative day 1, and the levels in 2 cases with TNS were markedly elevated over 10-fold higher than baseline. Furthermore, the postoperative MMP-9 levels were significantly elevated on each day. On the other hand, there was no significant fluctuation in claudin 5, vascular endothelial-cadherin, and MMP-2 level. CONCLUSIONS:Marked changes in biomarkers representing the tight junction of the BBB were observed. These preliminary results suggest that marked hemodynamic change and TNS in some patients are associated with disruption of the BBB after direct bypass surgery for MMA.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Ishii D,Matsushige T,Okazaki T,Shinagawa K,Sakamoto S,Oshita J,Kurisu Kdoi
10.1016/j.wneu.2018.08.134subject
Has Abstractpub_date
2018-12-01 00:00:00pages
e611-e616eissn
1878-8750issn
1878-8769pii
S1878-8750(18)31917-Xjournal_volume
120pub_type
杂志文章abstract：CASE DESCRIPTION:A 20-year-old woman presented with a rare intracranial inflammatory myofibroblastic tumor (IMT) manifesting as headache and insomnia. Magnetic resonance imaging showed a tumorous lesion with heterogeneous enhancement at the right temporal lobe, as well as perifocal edema with midline shift. The tumor w...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.07.060
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To examine the effects of chronic preoperative steroid therapy on 30-day perioperative complications after anterior lumbar fusion (ALF). METHODS:We retrospectively analyzed data from the American College of Surgeons National Surgical Quality Improvement Program between 2008 and 2015. Adult patients who under...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.02.048
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:This study sought to 1) describe the use K-wireless pedicle screw insertion among adults (age ≥18 years) undergoing a minimally invasive fusion and 2) perform a systematic review (SR) of all studies that describe a navigated, K-wireless technique with 3-dimensional fluoroscopy. METHODS:Patients undergoing a ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.02.079
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Cerebral venous complications related to neurosurgical interventions are only rarely reported in the literature. Internal cerebral veins (ICVs) are vulnerable to injury during neurosurgical approaches to the pineal and thalamic regions. The occurrence of unilateral postoperative ICV thrombosis in children is...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2020.03.008
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:When resident physicians fail to demonstrate appropriate milestone competencies early in their neurologic surgery residency, a plan of remediation is necessary. METHODS:Once any psychologic, physical, or behavioral causes of identified knowledge or psychomotor deficiencies have been identified and addressed...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.11.108
更新日期：2020-11-27 00:00:00
abstract：OBJECTIVE:Deep brain stimulation (DBS) is an effective treatment for movement disorders. Stereotactic electrode placement can be guided by intraoperative imaging, which also allows for immediate intraoperative quality control. This article is about implementation and refining a workflow applying intraoperative computed...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.12.079
更新日期：2018-12-27 00:00:00
abstract：BACKGROUND:Tumor recurrence or incomplete resection in nonfunctioning pituitary adenomas (NFPAs) is relatively common. However, predictive factors of tumor recurrence in NFPAs are not well established. We evaluated possible factors related to tumor recurrence in a large cohort of NFPAs at a single pituitary neurosurger...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.08.043
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes. This ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2011.07.014
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Approximately 2%-10% of all central nervous system tumors are primary spinal cord tumors (SCTs). Spinal cord glioblastoma is a rare tumor type accounting for 1%-3% of all SCTs and 7.5% of all spinal cord gliomas. Notably, the small-cell variant of spinal cord glioblastoma is even rarer with only 2 previously...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2018.07.007
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:Work hour restrictions and current quality, financial, and legal concerns have reduced resident operative volume and autonomy. Although laboratory (cadaveric or animal) dissection has a rich history in neurosurgery, its current role in resident training is unclear. Recent literature suggests educators have lo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.05.028
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:Simulation models enable trainees to master microsurgical skills before performing surgeries. Vascular bypass is a critical component of cerebrovascular and many nonneurologic procedures. However, most available bypass training models lack important spatial, tactile, and physiologic aspects of real surgery. A...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.02.107
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Previous studies compared outcomes of intracranial meningioma surgery in octogenarians with outcomes in younger patients without accounting for different tumor locations and sizes. The aim of the current study was to evaluate outcomes of intracranial meningioma surgery in octogenarians taking into account pa...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.09.001
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Tuberculum sella meningiomas typically present with progressive visual loss. It is also known that meningiomas can become symptomatic during pregnancy. Herein we report on 3 patients who presented with progressive visual decline during pregnancy, prompting urgent surgical removal of their meningiomas. CASE ...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.07.198
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Ganglion cysts mostly occur in the knuckles and wrists, but they rarely present in the odontoid process and can cause neurological symptoms by compressing the spinal cord. They are mostly localized in the epidural space, but may very rarely appear in the intradural space. There are no reports of cases of int...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.08.120
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Symptomatic cerebral vasospasm has been reported in a low percentage of patients with moderate or severe traumatic brain injury (TBI) as defined by Glasgow Coma Scale (GCS) score. We present a case of mild TBI (GCS score 14) complicated by early and severe symptomatic cerebral vasospasm. CASE DESCRIPTION:A ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.03.039
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:Reducing complications from unruptured aneurysms (UAs) treatment is important. We clarify the criteria for achieving safe and complete treatment for UAs ≤10 mm by clipping or coil embolization. METHODS:This study included 59 newly treated UAs in the past 2 years. We prospectively decided on criteria to recom...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.04.005
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:An increasing body of literature describing use of high-fidelity surgical training models is challenging long-held dogma that cadavers provide the best medium for postgraduate surgical skills training. The purpose of this study was to describe a surgical skills course comprising entirely synthetic training m...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.230
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:We sought to (1) describe psychological, physical, and cognitive functions in patients 10 years after intracranial aneurysm rupture and (2) identify any differences in outcome variables between age groups, gender or aneurysm locations. METHODS:A consecutive sample of patients (n=217) treated for intracranial...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2012.03.032
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Little published data exist regarding normal values of disc height. Current literature relies on plain radiographs making accurate measurements of individual lumbar disc height difficult. OBJECTIVE:We seek to establish normal values for lumbar intervertebral discs in different age groups using computed tomo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.12.014
更新日期：2018-12-20 00:00:00
abstract：BACKGROUND:Brain abscesses are well-known to neurologic surgeons with well-recognized presentations, which include seizures, neurologic deficit, and headache. Rare symptoms may lead to a delay in diagnosis, which can be life threatening in the setting of a brain abscess. CASE DESCRIPTION:We present the case of a 46-ye...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.139
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Traumatic posterior fossa subdural hemorrhage (SDH) is a rare subtype of subdural hemorrhage in head injuries. Existing data on its pathophysiology and outcome are currently limited; therefore, the condition is not yet fully understood. The present study aimed to determine the incidence, outcome, and prognos...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2018.07.191
更新日期：2018-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.02.110
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Giant cell tumors (GCTs) are benign tumors with a predilection for the epimetaphyseal region of the long bones. GCTs involving the skull base are rare, and only a few available cases have been reported. Surgical gross total resection is the recommended method of treatment for GCTs. In the case of skull base ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.07.207
更新日期：2018-11-01 00:00:00
abstract：:Foramen magnum meningiomas represent a challenge for neurosurgeons. These tumors require careful surgical manipulation as they are often located in proximity to critical neurovascular structures and the cranial nerves. The far lateral approach is considered the safest neurosurgical approach for excising foramen magnum...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2017.07.029
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Arachnoiditis ossificans (AO) is a rare entity characterized by the presence of calcified plaques formed by the metaplasia of arachnoid cells. Over 50 cases of AO have been reported, with predisposing factors including spinal trauma, hemorrhage, vascular abnormalities, and infection. The administration of oi...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.02.178
更新日期：2019-06-01 00:00:00
abstract：:Gross total resection of large intracranial meningiomas (LIMs) can be challenging and cause significant morbidity and mortality. The aim of this systematic review is to determine the clinical effectiveness and safety of stereotactic radiosurgery (SRS) either as primary or adjuvant therapy for LIMs with tumors ≥2.5 cm ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.06.064
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:To determine the predictive factors for endocrinological remission of patients with growth hormone (GH)-secreting pituitary adenomas. METHODS:In 47 patients with GH-secreting pituitary adenomas who underwent endoscopic endonasal transsphenoidal surgery with intraoperative GH measurements from 2002 to 2011, t...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.162
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Postoperative hemorrhage (POH), an uncommon complication after cranial operation, may result in prolonged postoperative hospitalization, severe neurologic impairment, or even death. Most models in studies detecting risk factors for POH include all kinds of cranial lesions; however, factors associated with PO...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.05.239
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Intraoperative use of positive end-expiratory pressure (PEEP) has a protective effect in patients with acute lung injury and is recommended during anesthesia to minimize postoperative pulmonary complications. However, high levels of pressure might also cause harm to the lung because of overdistension. This r...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.12.014
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:Flow diversion has emerged as a promising strategy for management of intracranial aneurysms. The purpose of this study was to determine whether treatment of large and giant aneurysms with the pipeline embolization device (PED) is more economical than traditional embolization strategies. METHODS:We identified...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2013.02.089
更新日期：2014-11-01 00:00:00
