Abstract:
BACKGROUND:The aim of the study was to describe the profile of patients and the characteristics of all bacteremias caused by multidrug-resistant (MDR) bacterial strains in a teaching hospital and to assess the mortality related to these events. METHODS:A monocentric retrospective observational cohort study was conducted. All patients with bacteremia caused by MDR bacteria between 2011 and 2013 were included. The characteristics of patients and bacteremias, antibiotic therapy within the first day, and 30-day mortality were collected from the electronic medical records database. RESULTS:A total of 228 patients were included with bacteremias caused by Enterobacteriaceae-producing extended-spectrum β-lactamase (n = 102), Enterobacteriaceae overproducing AmpC β-lactamase (n = 59), carbapenem-resistant Enterobacteriaceae (n = 3), ceftazidime- or carbapenem-resistant Acinetobacter baumannii (n = 2), ceftazidime- or carbapenem-resistant Pseudomonas aeruginosa (n = 23), methicillin-resistant Staphylococcus aureus (n = 40), and vancomycin-resistant Enterococcus (n = 2). The median Charlson comorbidity score was 6. Inappropriate antibiotic therapy was prescribed in 41.7% of bacteremias, and 30-day mortality was 23%. For 20.9% of the patients who had had a positive bacteriologic sample in the preceding 2 months, the initial antibiotic therapy was inappropriate. CONCLUSION:In this cohort of bacteremia patients, a high rate of mortality and numerous patient comorbidities were observed. Taking greater account of antecedents of MDR bacterial infections could improve the rate of appropriate initial antibiotic therapy.
journal_name
Am J Infect Controljournal_title
American journal of infection controlauthors
Picot-Guéraud R,Batailler P,Caspar Y,Hennebique A,Mallaret MRdoi
10.1016/j.ajic.2015.05.004subject
Has Abstractpub_date
2015-09-01 00:00:00pages
960-4issue
9eissn
0196-6553issn
1527-3296pii
S0196-6553(15)00515-5journal_volume
43pub_type
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