Abstract：
:The diagnosis of a high-grade glioma usual is followed by functional impairment(s), cognitive decline and an impaired psycho-social well-being. This might well have a significant and negative impact on the health related quality of life. The purpose of this study was to explore physical activity levels, prevalence and severity of anxiety and depressive symptoms and health-related quality of life among patients with a highgrade glioma. This paper is based on a longitudinal mixed methods study. Patients (n = 30) completed questionnaires at 5 time points from time of diagnosis until the final follow-up after 1 year. Scores of Karnofsky Performance Status (KPS), physical activity, anxiety and depression and health-related quality of life (FACT-Br) are obtained. Patients' physical activity level and KPS decrease during the disease- and treatment trajectory. The majority of patients did not report any depressive symptoms, eight individuals (26.7 %) being depressed at various time points. Among a sub-group of participants who completed all study requirements for the entire study period the level of anxiety decreased significantly during the study. The FACT-Br sub-scale of emotional well-being increased significant, indicating a better HRQOL attend of followup. The diagnosis of a HGG leads to an ongoing functional decline measured as a decline of the KPS and a reduced physical activity during leisure time. Supportive care combined with rehabilitative and palliative approaches might well be valuable along the trajectory especially during the post-surgery period when anxiety is at its highest peak.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Piil K,Jakobsen J,Christensen KB,Juhler M,Jarden Mdoi
10.1007/s11060-015-1821-2subject
Has Abstractpub_date
2015-09-01 00:00:00pages
185-95issue
2eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-015-1821-2journal_volume
124pub_type
杂志文章abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
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更新日期：2019-10-01 00:00:00
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更新日期：2010-10-01 00:00:00
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更新日期：2017-12-01 00:00:00
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更新日期：2014-05-01 00:00:00
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更新日期：2017-08-01 00:00:00
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更新日期：1998-09-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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更新日期：2016-11-01 00:00:00
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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更新日期：2008-03-01 00:00:00
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更新日期：2007-04-01 00:00:00
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更新日期：2009-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0781-4
更新日期：2012-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1547-6
更新日期：2014-10-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00172458
更新日期：1992-01-01 00:00:00
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更新日期：2010-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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更新日期：2001-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2005-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
abstract：PURPOSE:Stereotactic radiosurgery is an established treatment option for sporadic meningiomas, though limited data exists for radiation-induced lesions. METHODS:Patients treated with cobalt-60 radiosurgery between October 2005 and December 2018 in an institutional registry were reviewed. Single fraction treatments wer...
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pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
abstract：:Cavernous angiomas of the spinal cord exhibit imaging characteristics that may overlap with those of hemorrhagic ependymoma. In the present study, we aimed to identify specific magnetic resonance imaging (MRI) findings that could be used to differentiate cavernous angioma from hemorrhagic ependymoma, and to evaluate s...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2239-1
更新日期：2016-10-01 00:00:00
abstract：:Children with high-grade glioma (HGG) have a poor prognosis compared to those with low-grade glioma (LGG). Adjuvant chemotherapy may be beneficial, but its optimal use remains undetermined. Histology and extent of resection are important prognostic factors. We tested the hypothesis that patients with midline HGG treat...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,随机对照试验
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更新日期：2015-02-01 00:00:00
