Atypical glandular cells of undetermined significance: implications for management in a dysplasia clinic.

Abstract:

OBJECTIVE:The natural evolution of atypical glandular cells of undetermined significance (AGUS) within a dysplasia clinic population has not yet been studied. The purpose of this study was to determine the outcome of cervico-vaginal smears with the diagnosis of AGUS from dysplasia clinic patients. MATERIAL AND METHODS:The cytopathological files of the Ottawa Civic Hospital were reviewed retrospectively from January 1993 to December 1995. In 59 dysplasia clinic patients, AGUS was diagnosed on one or more cervico-vaginal smears. Histological follow-up was available from 34 patients. Cytological follow-up was available on an additional 17 patients. RESULTS:Nineteen patients had clinically significant lesions. In eight patients, squamous intraepithelial neoplasia was diagnosed; in five, adenocarcinoma in situ; in another five, adenocarcinoma; and, in one patient, endometrial hyperplasia with atypia. In 15 patients, follow-up was negative. CONCLUSION:In a dysplasia clinic population in whom there was a cytological diagnosis of AGUS, we found 32% had significant pathology. Of these patients, 53% had glandular pathology. Based on our experience, histological assessment of the endocervix is suggested in these patients.

journal_name

J Low Genit Tract Dis

authors

Parai JL,Yazdi HM,Faught JW

doi

10.1097/00128360-199810000-00001

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

185-90

issue

4

eissn

1089-2591

issn

1526-0976

pii

00128360-199810000-00001

journal_volume

2

pub_type

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