Efficacy of treatment of inflammatory cytologic abnormalities detected by papanicolaou smears: a pilot study.

Abstract:

OBJECTIVE:To evaluate the efficacy of metronidazole versus no treatment for the empiric treatment of inflammatory cytologic changes. MATERIALS AND METHODS:Patients with inflammatory changes on Pap smear were serially assigned to receive no treatment or metronidazole by one of three regimens: 2 grams orally as a single dose, 500 milligrams orally twice daily for 7 days, or 5 grams (in gel form) vaginally twice daily for 5 days. Smears were repeated 3 months after treatment. RESULTS:The repeat smear was normal in 47 of 63 patients treated with a single dose, 40 of 62 patients treated orally for 7 days, 14 of 21 patients treated with vaginal gel, and 29 of 49 of the control group. Chi-square analysis showed no statistical significance between groups. CONCLUSION:There is no statistically significant difference in the resolution of cytologic inflammatory changes among the study groups. Empiric metronidazole treatment has no benefit.

journal_name

J Low Genit Tract Dis

authors

Webb JC,Wharton GG,Hawley-Bowland C,Carlson JW

doi

10.1046/j.1526-0976.2001.005002082.x

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

82-4

issue

2

eissn

1089-2591

issn

1526-0976

pii

00128360-200104000-00003

journal_volume

5

pub_type

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