Biopsy site selection during colposcopy and distribution of cervical intraepithelial neoplasia.

Abstract:

OBJECTIVE:To determine if sites selected for colposcopic biopsy and histologically proven cervical intraepithelial neoplasia are distributed randomly across the cervix. MATERIALS AND METHODS:Data were evaluated from all patients who visited the Walter Reed Army Medical Center Colposcopy Clinic during a 20-month period. chi analysis was performed to assess the randomness of distribution of biopsies and cervical intraepithelial neoplasia. RESULTS:In 303 patients, 479 biopsies were performed. The 11-, 12-, and 1-o'clock positions were selected for 190 of 479 (40%) of biopsies, whereas the 6- and 12-o'clock positions were chosen for 186 of 479 (39%) of biopsies (p < 0.0001). Of 479 specimens, 161 (34%) were diagnosed as low-grade and 57 (12%) were diagnosed as high-grade. The 6-, 11-, and 12-o'clock positions accounted for 32 of 57 (56%) high-grade biopsies (p < 0.0001). The 6- and 12-o'clock positions accounted for 61 of 161 (38%) low-grade biopsies (p < 0.0001). CONCLUSIONS:Loci selected for biopsy and histologically confirmed cervical intraepithelial neoplasia are not randomly distributed across the cervix. There is a predilection for the locations anterior and posterior to the cervical os.

journal_name

J Low Genit Tract Dis

authors

Allard JE,Rodriguez M,Rocca M,Parker MF

doi

10.1097/00128360-200501000-00008

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

36-9

issue

1

eissn

1089-2591

issn

1526-0976

pii

00128360-200501000-00008

journal_volume

9

pub_type

杂志文章
  • Vulvar intraepithelial neoplasia: a synopsis of recent developments.

    abstract::This review highlights recent advances in our understanding of preneoplastic squamous lesions of the vulva, from a pathologist's perspective. Vulvar intraepithelial neoplasia (VIN) is the preferred nomenclature for these lesions. VIN lesions may or may not be symptomatic and have a variable clinical appearance. Three ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-199801000-00007

    authors: Colgan TJ

    更新日期:1998-01-01 00:00:00

  • Hair in the vagina: a case series.

    abstract:BACKGROUND:: Lack of estrogen after menopause can cause many changes in the lower genital tract of women, including involution of the introitus and collapse of the vestibule into the genital cleft. CASES:: Six cases of hypoestrogenic women are described, with the unusual finding of entrapment of terminal hairs between...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31821a68a5

    authors: Vigliani MB

    更新日期:2011-10-01 00:00:00

  • Giant condyloma versus verrucous carcinoma: a case report.

    abstract::Giant condyloma acuminatum is a large, slow-growing, exophytic, cauliflower-like tumor of the external genitalia. It is a histologically benign lesion, largely associated with human papillomavirus infection but with a high recurrence rate. The main differential diagnosis includes verrucous carcinoma. Differentiation b...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3181c945ed

    authors: Bambao C,Nofech-Mozes S,Shier M

    更新日期:2010-07-01 00:00:00

  • Efficacy of treatment of inflammatory cytologic abnormalities detected by papanicolaou smears: a pilot study.

    abstract:OBJECTIVE:To evaluate the efficacy of metronidazole versus no treatment for the empiric treatment of inflammatory cytologic changes. MATERIALS AND METHODS:Patients with inflammatory changes on Pap smear were serially assigned to receive no treatment or metronidazole by one of three regimens: 2 grams orally as a single...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1046/j.1526-0976.2001.005002082.x

    authors: Webb JC,Wharton GG,Hawley-Bowland C,Carlson JW

    更新日期:2001-04-01 00:00:00

  • ASCCP Colposcopy Standards: Role of Colposcopy, Benefits, Potential Harms, and Terminology for Colposcopic Practice.

    abstract:OBJECTIVES:The American Society for Colposcopy and Cervical Pathology Colposcopy Standards address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. Working Group 1 was tasked with defining the role of colposcopy, describing benefits and potential harms, and developi...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0000000000000338

    authors: Khan MJ,Werner CL,Darragh TM,Guido RS,Mathews C,Moscicki AB,Mitchell MM,Schiffman M,Wentzensen N,Massad LS,Mayeaux EJ Jr,Waxman AG,Conageski C,Einstein MH,Huh WK

    更新日期:2017-10-01 00:00:00

  • Massive localized lymphedema of the vulva: report of a case and review of the literature.

    abstract:BACKGROUND:Massive localized lymphedema (MLL) is a recently described entity associated with obesity, most often on the thighs. It rarely occurs on the vulva, and it may pose diagnostic difficulty for both clinician and pathologist in this setting. CASE:An obese 55-year-old woman underwent excision of bilateral polypo...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0b013e31829cf432

    authors: Heller DS,Fitzhugh VA,Cracchiolo B,Barrett T Jr,Suidan RS

    更新日期:2014-04-01 00:00:00

  • A rare case of ectopic adrenocorticotropic hormone syndrome in small cell carcinoma of the vagina: a case report.

    abstract:OBJECTIVE:To describe ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) to increase awareness of this condition when treating patients with gynecological small cell carcinoma (SmCC). MATERIALS AND METHODS:This is a review of a 61-year-old woman with primary vaginal SmCC and an atypical presentation of Cushing ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31815cda1e

    authors: Weberpals J,Djordjevic B,Khalifa M,Oza A

    更新日期:2008-04-01 00:00:00

  • Atypical glandular cells of undetermined significance: implications for management in a dysplasia clinic.

    abstract:OBJECTIVE:The natural evolution of atypical glandular cells of undetermined significance (AGUS) within a dysplasia clinic population has not yet been studied. The purpose of this study was to determine the outcome of cervico-vaginal smears with the diagnosis of AGUS from dysplasia clinic patients. MATERIAL AND METHODS...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-199810000-00001

    authors: Parai JL,Yazdi HM,Faught JW

    更新日期:1998-10-01 00:00:00

  • Cervical cancer in pregnancy: 3 cases, 3 different approaches.

    abstract:OBJECTIVE:Cervical cancer is one of the most common malignancies in pregnancy and one percent of women diagnosed with cervical cancer are pregnant or postpartum at the time of the diagnosis. We discuss how pregnancy will affect the management of cancer, and cancer will affect the management of the pregnancy. MATERIAL ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31824d6fb8

    authors: Ribeiro F,Correia L,Paula T,Santana I,Vieira Pinto L,Borrego J,Jorge AF

    更新日期:2013-01-01 00:00:00

  • The vaginal vestibule.

    abstract:OBJECTIVES:Vulvar vestibule is a common term in the medical nomenclature. In our view, this term is inaccurate. MATERIALS AND METHODS:Herein, we provide evidence from embryologic, anatomic, and architectonic textbooks that shows the links between the vestibule and vagina. RESULTS:Our research proves that the term vul...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200401000-00014

    authors: Friedman M,Siegler E,Löwenstein L

    更新日期:2004-01-01 00:00:00

  • Direct visual inspection of the cervix with Lugol iodine for the detection of premalignant lesions.

    abstract:OBJECTIVE:To evaluate the feasibility and efficiency of direct visual inspection after Lugol iodine painting in detecting cervical premalignant and malignant lesions. MATERIALS AND METHODS:This study included 1,012 women recruited from gynecology outpatient clinic screened for premalignant or malignant lesions of the ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31815f527c

    authors: El-Shalakany AH,Saeed MM,Abdel-Aal MR,El-Nakeeb AH,Noseirat N,Ayyad SB,El Din ZS

    更新日期:2008-07-01 00:00:00

  • Contribution of Exocervical Biopsy, Endocervical Curettage, and Colposcopic Grading in Diagnosing High-Grade Cervical Intraepithelial Neoplasia.

    abstract:OBJECTIVE:To determine the utility of random biopsy and endocervical curettage (ECC) during colposcopy among women who ultimately underwent cervical excisional biopsy. MATERIALS AND METHODS:In a retrospective observational study, the charts were reviewed of every patient who underwent cervical excisional procedure per...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182a5296e

    authors: Diedrich JT,Felix JC,Lonky NM

    更新日期:2016-01-01 00:00:00

  • Spray Versus Forced Coagulation in Large Loop Excision of the Transformation Zone: A Randomized Trial.

    abstract:OBJECTIVE:Large loop excision of the transformation zone (LLETZ) is the standard surgical treatment for cervical dysplasia. The optimal way to achieve local hemostasis in women undergoing LLETZ is unknown. MATERIALS AND METHODS:In a prospective, randomized trial, we compared spray coagulation and forced coagulation in...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/LGT.0000000000000177

    authors: Hilal Z,Mavrommati G,Foerster C,Rezniczek GA,Hefler LA,Tempfer CB

    更新日期:2016-04-01 00:00:00

  • Comparison of Tissue Yield Using Frictional Fabric Brush Versus Sharp Curettage For Endocervical Curettage.

    abstract:OBJECTIVE:The aim of the study was to evaluate and compare the diagnostic yield of conventional endocervical curettage (ECC) with fabric-based ECC in a consistent physician group. MATERIALS AND METHODS:This is a retrospective case-control study of patients who underwent ECC both before and after introduction of a fabr...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000324

    authors: Diedrich JT,Rathore S,Bentz JS

    更新日期:2017-10-01 00:00:00

  • Assessment of Anal Cancer Screening Tools in Detecting High-Grade Anal Squamous Intraepithelial Lesions in Women.

    abstract:OBJECTIVE:The aim of the study was to evaluate the validity of anal cytology against high-resolution anoscopy in the detection of anal high-grade squamous intraepithelial lesions (HSILs) among women in a clinical setting in Puerto Rico, alone and in combination with high-risk human papillomavirus (HR-HPV) typing. MATE...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000497

    authors: Ramos-Cartagena JM,Pérez CM,Guiot HM,Amaya-Ardilla CP,Tirado-Gómez M,Ortiz AP

    更新日期:2020-01-01 00:00:00

  • The accuracy of colposcopic grading for detection of high-grade cervical intraepithelial neoplasia.

    abstract:OBJECTIVE:To relate aspects of online colposcopic image assessment to the diagnosis of grades 2 and 3 cervical intraepithelial neoplasia (CIN 2+). METHODS:To simulate colposcopic assessment, we obtained digitized cervical images at enrollment after acetic acid application from 919 women referred for equivocal or minor...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31819308d4

    authors: Massad LS,Jeronimo J,Katki HA,Schiffman M,National Institutes of Health\/American Society for Colposcopy and Cervical Pathology Research Group.

    更新日期:2009-07-01 00:00:00

  • Use of Smartphones as Adjuvant Tools for Cervical Cancer Screening in Low-Resource Settings.

    abstract:OBJECTIVES:Our aim was to evaluate the feasibility and performance of smartphone digital images for the detection of cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) as an adjunct to a conventional visual inspection approach with acetic acid (VIA) and Lugol's iodine (VILI), in comparison with detection by...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000136

    authors: Ricard-Gauthier D,Wisniak A,Catarino R,van Rossum AF,Meyer-Hamme U,Negulescu R,Scaringella S,Jinoro J,Vassilakos P,Petignat P

    更新日期:2015-10-01 00:00:00

  • Abnormal pap tests and human papillomavirus infections among HIV-infected and uninfected women who have sex with women.

    abstract:OBJECTIVE:To estimate the frequency of abnormal Pap and human papillomavirus (HPV) positivity among human immunodeficiency virus (HIV)-seropositive and -seronegative women who have sex with women (WSW). METHODS:Pap and HPV DNA polymerase chain reaction tests were obtained every 6 months from women in a US cohort of HI...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/LGT.0b013e3182942733

    authors: Massad LS,Xie X,Minkoff H,Darragh TM,D'Souza G,Sanchez-Keeland L,Watts DH,Colie C,Strickler HD

    更新日期:2014-01-01 00:00:00

  • Telomerase activity as a potential diagnostic marker for triage of abnormal Pap smears.

    abstract:OBJECTIVES:To determine whether there is an association between high levels of telomerase and premalignant cervical disease and to provide a preliminary analysis of telomerase activity as a potential triage strategy. MATERIALS AND METHODS:Premenopausal women were invited to participate in the study during routine gyne...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200504000-00005

    authors: Ault KA,Allen HK,Phillips SL,Zimmerman MB,Klingelhutz AJ

    更新日期:2005-04-01 00:00:00

  • Recommendations and administration of the HPV vaccine to 11- to 12-year-old girls and boys: a statewide survey of Georgia vaccines for children provider practices.

    abstract:OBJECTIVE:This study explores the prevalence and provider- and practice-related correlates of physician recommendation and administration of the quadrivalent human papillomavirus (HPV) vaccine, Gardasil, to 11- to 12-year-old girls and the intention to recommend the HPV vaccine to 11- to 12-year-old boys in Georgia. Th...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000011

    authors: Luque JS,Tarasenko YN,Dixon BT,Vogel RL,Tedders SH

    更新日期:2014-10-01 00:00:00

  • Is colposcopy warranted in women with external anogenital warts?

    abstract::OBJECTIVES.: To determine the prevalence of cervical dysplasia, diagnosed cytologically (squamous intraepithelial lesion [SIL]) or histologically (cervical intraepithelial neoplasia [CIN]), in women with external anogenital warts, and to determine the discriminating risk factors between those with and without cervical...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200301000-00006

    authors: Li J,Rousseau MC,Franco EL,Ferenczy A

    更新日期:2003-01-01 00:00:00

  • High-risk HPV infection and CIN grade correlates to the expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a.

    abstract:OBJECTIVE:: This study aimed to investigate correlations between a panel of biomarkers/tumor markers and high-risk (HR) human papillomavirus (HPV)-positive versus HR-HPV-negative cervical lesions. MATERIALS AND METHODS:: The study included 188 women who consecutively attended a colposcopy clinic because of PAP smears ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e318215170c

    authors: Samir R,Asplund A,Tot T,Pekar G,Hellberg D

    更新日期:2011-10-01 00:00:00

  • A Randomized Trial of Human Papillomavirus Self-Sampling as an Intervention to Promote Cervical Cancer Screening Among Women With HIV.

    abstract:OBJECTIVE:Women living with HIV experience higher risk of cervical cancer, but screening rates in the United States are lower than recommended. The purpose of this study was to examine whether an intervention using self-sampling of cervicovaginal cells for human papillomavirus (HPV) with results counseling would increa...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/LGT.0000000000000195

    authors: Murphy J,Mark H,Anderson J,Farley J,Allen J

    更新日期:2016-04-01 00:00:00

  • Pseudoepitheliomatous hyperplasia mimicking vulvar cancer in a patient with AIDS.

    abstract:BACKGROUND:Pseudoepitheliomatous hyperplasia (PEH) clinically and histologically mimics squamous cell carcinoma (SCC), specifically in patients with HIV and AIDS. CASE:A 51-year-old G3P2 with AIDS and history of vulvar cancer presented with large bilateral exophytic lesions on the vulva, grossly appearing neoplastic. ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3181f0b8f5

    authors: Frimer M,Chudnoff S,Hebert T,Shahabi S

    更新日期:2011-01-01 00:00:00

  • Metronidazole vaginal gel 1.3% in the treatment of bacterial vaginosis: a dose-ranging study.

    abstract:OBJECTIVE:Metronidazole vaginal gel (MVG) 0.75% is a US Food and Drug Administration-approved, 5-day treatment for bacterial vaginosis (BV). This study tested the hypothesis that a shorter treatment course at a higher dose (MVG 1.3%) would yield similar efficacy to 5 days of MVG 0.75%. MATERIALS AND METHODS:This phase...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/LGT.0000000000000062

    authors: Chavoustie SE,Jacobs M,Reisman HA,Waldbaum AS,Levy SF,Hillier SL,Nyirjesy P

    更新日期:2015-04-01 00:00:00

  • The accuracy of the Papanicolaou smear in the screening and diagnostic settings.

    abstract:OBJECTIVE:We evaluated the performance of the Papanicolaou smear in screening and diagnostic settings. STUDY DESIGN:We analyzed Papanicolaou smear results of 1,850 women recruited into a clinical trial to evaluate an emerging technology for the detection of cervical cancer. Screening and diagnosis groups were based on...

    journal_title:Journal of lower genital tract disease

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/LGT.0b013e31816b44bc

    authors: Cárdenas-Turanzas M,Follen M,Nogueras-Gonzalez GM,Benedet JL,Beck JR,Cantor SB

    更新日期:2008-10-01 00:00:00

  • Validity of the Papanicolaou Smear in the Diagnosis of Candida spp., Trichomonas vaginalis, and Bacterial Vaginosis.

    abstract:OBJECTIVE:To determine the validity of the Papanicolaou smear in the diagnosis of bacterial vaginosis, Trichomonas vaginalis, and Candida spp. MATERIALS AND METHODS:We determined the sensitivity, specificity, positive predictive value, and negative predictive value of Pap smears we performed in 824 symptomatic patient...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:

    authors: Audisio T,Pigini T,de Riutort SV,Schindler L,Ozan M,Tocalli C,Bertolotto P

    更新日期:2001-10-01 00:00:00

  • Incidence of cervical intraepithelial neoplasia in Estonia.

    abstract:OBJECTIVE:This study aimed to assess the incidence of cervical intraepithelial neoplasia (CIN) by grade (CIN 1, CIN 2, CIN 3) and age in Estonia (a country with less developed cervical cancer screening program and high cervical cancer incidence). MATERIALS AND METHODS:This descriptive study uses data from a health ins...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182652213

    authors: Uusküla A,Raag M,Uppin A,Raud T,Klaar U,Jürisson M,Müürsepp A

    更新日期:2013-04-01 00:00:00

  • Home study course: summer 2005.

    abstract:OBJECTIVE:The Home Study Course is intended for the practicing colposcopist or practitioner who is seeking to develop or enhance his or her colposcopic skills. The goal of the course is to present colposcopic cases that are unusual or instructive in terms of appearance, presentation, or management, or that demonstrate ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000171660.77437.f2

    authors: Berry JM,Darragh TM

    更新日期:2005-07-01 00:00:00

  • Natural history of low-grade squamous intraepithelial lesion.

    abstract:OBJECTIVE:To determine guidelines for management of CIN1 by evaluating its natural history. METHODS:One hundred fifty-eight patients were diagnosed with CIN1 had colposcopy follow-up with or without cytology every three months. RESULTS:Colposcopically directed biopsy confirmed progression to CIN2 or CIN3 in 17 of 158...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:

    authors: Saw HS,Lee JK,Lee HL,Jee HJ,Hyun JJ

    更新日期:2001-07-01 00:00:00