Hepatitis C virus-HIV-coinfected patients and liver transplantation.

abstract：PURPOSE OF REVIEW:Exposure to noninherited maternal antigens (NIMAs) in fetal and neonatal life has life-long immunological consequences. Although there is a plethora of evidence of effects of mother on the immune responses of her offspring, there is very little knowledge available on how exposure to NIMA can result in...

journal_title：Current opinion in organ transplantation

authors： Dutta P,Burlingham WJ

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary graft failure, which represents one of the most frequent causes of early mortality, is mostly caused by ischemia-reperfusion injury (IRI). IRI may also induce rejection, which is the principal cause of mortality after transplantation. It is essential to understand the mechanism of pulmonary IR...

journal_title：Current opinion in organ transplantation

authors： Chen F,Date H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Dysregulated coagulation is now recognized as a major contributor to graft loss in xenotransplantation. This review summarizes recent data on putative mechanisms of pathogenic coagulation in xenotransplantation and discusses progress on strategies to overcome them. RECENT FINDINGS:Evidence continues ...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,d'Apice AJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The trend to extubate patients as soon as possible following large and complex surgery is supported by a large body of evidence showing early extubation is safe and saves money. However, the use of early extubation in liver transplant recipients is still debated. This review will explore the reasons w...

journal_title：Current opinion in organ transplantation

authors： Mandell MS,Campsen J,Zimmerman M,Biancofiore G,Tsou MY

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Memory T cells have emerged as a major threat to transplant survival; they are well equipped and well positioned to respond to antigens in an accelerated fashion. They participate in transplant rejection and resist interventions that usually contain naïve T cells. Thus, the means to prevent memory T c...

journal_title：Current opinion in organ transplantation

authors： Valujskikh A,Li XC

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To define the natural history of kidney allograft loss related to recurrent diabetes following transplant, and to understand the potential benefit of pancreas transplantation upon kidney allograft survival. RECENT FINDINGS:A postulated benefit of simultaneous pancreas kidney transplant is that, unlik...

journal_title：Current opinion in organ transplantation

authors： Wiseman AC,Stites E,Kennealey P

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the complex interplay between the microbiota and host immune responses, and its impact on intestinal transplantation and allograft rejection. RECENT FINDINGS:Recent findings highlight the importance of Paneth cells as crucial producers of antimicrobial peptides that control th...

journal_title：Current opinion in organ transplantation

authors： Kroemer A,Elsabbagh AM,Matsumoto CS,Zasloff M,Fishbein TM

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Blood loss in orthotopic liver transplantation has declined during the past decade. Recent papers addressed this issue and emphasized its importance, because there is a significant correlation between intraoperative blood transfusion requirements and postoperative morbidity. This review addresses chan...

journal_title：Current opinion in organ transplantation

authors： Groenland TH,Porte RJ,Metselaar HJ

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent reports on whole pancreas and islet cell transplantation. It focuses on 'what the call to the future looks like' for both therapies as treatment options for those type 1 diabetes patients who do not respond well to conventional therapy. RECENT FINDINGS:The ...

journal_title：Current opinion in organ transplantation

authors： Vardanyan M,Parkin E,Gruessner C,Rodriguez Rilo HL

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To deeply investigate one type of intracellular cardiac storage disease, the Fabry disease and one example of extracellular cardiac storage disease, the cardiac amyloidosis, with the aim to collect data about cardiac treatment at the end-stage level and the feasibility of heart transplantation (HTx) i...

journal_title：Current opinion in organ transplantation

authors： Di Nora C,Livi U

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute and chronic kidney disease is a leading cause of morbidity and mortality worldwide with overall mortality rates between 50 and 80%. An acute shortage of compatible organs coupled with limited adaptability of current dialysis techniques has created a sense of urgency to investigate new alternativ...

journal_title：Current opinion in organ transplantation

authors： Chhabra P,Brayman KL

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:There continues to be an inadequate organ supply and lack of effective temporary support, for patients with liver failure. The purpose of this review is to discuss recent progress in the field of orthotopic pig-to-nonhuman primate (NHP) liver xenotransplantation (LXT). RECENT FINDINGS:From 1968 to 20...

journal_title：Current opinion in organ transplantation

authors： Patel MS,Louras N,Vagefi PA

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation provides the only proven method to restore long-term normoglycemia in patients with insulin-dependent diabetes mellitus. Although many studies describe the most important risk factors for short-term survival of a pancreas transplant, more information about factors that disting...

journal_title：Current opinion in organ transplantation

authors： Gruessner AC,Gruessner RW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Lung transplantation survival is still limited compared with other solid organ transplant modalities, due to a range of factors that are continuing to be elucidated. However, new research is emerging which indicates that the microbiome of the lungs, and of other organs, may have important implications...

journal_title：Current opinion in organ transplantation

authors： Mitchell AB

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:New immunosuppressive agents have decreased the incidence of acute rejection rates without improvement in long-term outcomes. Drug toxicity due to a narrow therapeutic index and individual variations in pharmacokinetics and pharmacodynamics significantly contributes to the inferior outcomes. This revi...

journal_title：Current opinion in organ transplantation

authors： Wavamunno MD,Chapman JR

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

journal_title：Current opinion in organ transplantation

authors： Dunn TB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of how intravenous omega-3 fatty acids (O3FAs) have been used to prevent and treat pediatric intestinal failure-associated liver disease (IFALD). This review will introduce the most recent and relevant human and basic science data on the topic, and comment on how alterative lipi...

journal_title：Current opinion in organ transplantation

authors： Venick RS,Calkins K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The bidirectional exchange of cells, both mature and progenitor types, at the maternal-fetal interface is a common feature of mammalian reproduction. The presence of semiallogeneic cells in a host can have significant immunological effects on transplantation tolerance and rejection. Here, we review re...

journal_title：Current opinion in organ transplantation

authors： Dutta P,Burlingham WJ

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Transplantation of islets of Langerhans is an emerging treatment procedure for patients with severe type 1 diabetes, but despite recent progress the procedure is associated with massive tissue loss caused by an inflammatory reaction termed instant blood-mediated inflammatory reaction (IBMIR). This rea...

journal_title：Current opinion in organ transplantation

authors： Nilsson B,Ekdahl KN,Korsgren O

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the current state of the epidemiology, diagnosis, and management of human herpesvirus 6 (HHV-6) infection after solid organ transplantation. RECENT FINDINGS:HHV-6 reactivates commonly during the early weeks after solid organ transplantation. However, disease due to HHV-6 is un...

journal_title：Current opinion in organ transplantation

authors： Razonable RR

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation may become clinically feasible once the mechanisms of graft loss and rejection are better understood. Inflammatory reactions to vasculature of grafted pig organs and pancreatic islets have been linked to procoagulant activation and consumption with resulting thrombosis that preclud...

journal_title：Current opinion in organ transplantation

authors： Schmelzle M,Schulte Esch J 2nd,Robson SC

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation. RECENT FINDINGS:During an alloresponse, Toll-like receptors can be engaged by both damage-induced endogenous ligands or mi...

journal_title：Current opinion in organ transplantation

authors： Alegre ML,Goldstein DR,Chong AS

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Islet transplantation has made great progress in recent years. This is a remarkable technical feat but raises the question of what the long-term benefits and risks are for type I diabetes recipients. RECENT FINDINGS:Graft survival continues to improve, and recent multicenter studies show that islet t...

journal_title：Current opinion in organ transplantation

authors： Holmes-Walker DJ,Kay TW

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Adoptive cell therapy using CD4FOXP3 regulatory T cells (Treg) has emerged as a promising therapeutic strategy to treat autoimmunity and alloimmunity. Preclinical studies suggest that the efficacy of Treg therapy can be improved by modifying the antigen specificity, stability and function of therapeut...

journal_title：Current opinion in organ transplantation

authors： Sicard A,Boardman DA,Levings MK

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of nonheart-beating donors (NHBD), as a source for liver grafts, is the only way to objectively increase the activity in liver transplantation. Through the use of more strict criteria, 1-year graft survival has increased from 50% in initial series to 84-100%. With respect to type II NHBD (fail...

journal_title：Current opinion in organ transplantation

authors： García-Valdecasas JC,Fondevila C

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. This review focuses on recipient-derived infection. Recent data are reviewed that assess the susceptibility of porcine...

journal_title：Current opinion in organ transplantation

authors： Millard AL,Mueller NJ

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss the current state of donation after circulatory death (DCD). We define the DCD donor and describe the current protocols in management of the DCD patient. We then discuss current techniques in organ procurement of the lung and abdominal organs. RECENT FINDINGS:Although donat...

journal_title：Current opinion in organ transplantation

authors： Algahim MF,Love RB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressiv...

journal_title：Current opinion in organ transplantation

authors： Nunes-Cabaço H,Sousa AE

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Increased miniaturization of ventricular assist devices (VADs) and new mechanical support strategies (MCS) has increased the use of MCS in the pediatric and congenital heart disease (CHD) population. This comes with the need for care providers specialized in this field to determine optimal patient and...

journal_title：Current opinion in organ transplantation

authors： Schweiger M,Lorts A,Conway J

更新日期：2018-06-01 00:00:00