The use of stem cells in kidney disease.

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is the leading cause of late morbidity and mortality in heart transplant patients and limits long-term survival. Immunosuppression following cardiac transplantation has traditionally comprised a calcineurin inhibitor in combination with mycophenolate mofetil or aza...

journal_title：Current opinion in organ transplantation

authors： Raichlin E,Kushwaha SS

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation may become clinically feasible once the mechanisms of graft loss and rejection are better understood. Inflammatory reactions to vasculature of grafted pig organs and pancreatic islets have been linked to procoagulant activation and consumption with resulting thrombosis that preclud...

journal_title：Current opinion in organ transplantation

authors： Schmelzle M,Schulte Esch J 2nd,Robson SC

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune monitoring is needed in small bowel transplantation (SBTx) because of a high incidence of rejection and graft loss, and life-threatening complications of high-dose prophylactic immunosuppression. RECENT FINDINGS:Clinical tests relevant to SBTx include methods to detect antidonor human leukocyt...

journal_title：Current opinion in organ transplantation

authors： Sindhi R,AshokKumar C,Mazariegos G,Nayyar N,Ningappa M,Soltys K,Bond G,Sun Q,Humar A,Abu-Elmagd K,Zeevi A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is activated by interferon-gamma and via tryptophan depletion and the production of proapoptotic downstream metabolites IDO suppresses adaptive T-cell-mediated immunity in inflammation, host immune defence and maternal tolerance. In additio...

journal_title：Current opinion in organ transplantation

authors： Brandacher G,Margreiter R,Fuchs D

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical trials testing novel kidney transplant therapies are challenged by low rates of long-term clinical outcomes such as death and graft loss. Herein, we critically review traditional and more recent strategies to expedite new therapies by minimizing sample size and follow-up duration using surrog...

journal_title：Current opinion in organ transplantation

authors： Maggiore U,Leventhal J,Cravedi P

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic steatohepatitis (NASH), obesity, and the metabolic syndrome are highly prevalent. NASH, a rare indication for liver transplantation in the early 1990s, is now the third most common indication. This review considers key aspects of the liver transplantation for NASH. RECENT FINDINGS:NASH i...

journal_title：Current opinion in organ transplantation

authors： Charlton M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Inducible pluripotent stem (iPS) cells derived from somatic cells represent a novel renewable source of tissue precursors. The potential of iPS cells is considered to be at least equivalent to that of human embryonic stem cells, facilitating the treatment or cure of diseases such as diabetes mellitus,...

journal_title：Current opinion in organ transplantation

authors： Robbins RD,Prasain N,Maier BF,Yoder MC,Mirmira RG

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Fulminant hepatic failure (FHF) is one of the more dramatic and challenging syndromes in clinical medicine. Time constraints and the scarcity of organs complicate the evaluation process in the case of patients presenting with FHF, raising ethical questions related to fairness and justice. The challeng...

journal_title：Current opinion in organ transplantation

authors： Appel J,Vaidya S

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Within the United States, donor heart and lung procurement varies between institutions and among surgeons within the same institution sometimes. The purpose of this article is to review the history of donor heart and lung procurement, the surgical techniques, and pitfalls. RECENT FINDINGS:The current...

journal_title：Current opinion in organ transplantation

authors： Copeland H,Copeland J,Hayanga JWA

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Living donation has a tremendous impact in bridging the gap between the shortage of organs and the growing list of transplant candidates but remains underutilized as a percentage of total transplants performed. This review focuses on obesity and social determinants of health as potential barriers to t...

journal_title：Current opinion in organ transplantation

authors： Kim J,Kim S,Genyk Y,Maw TT

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we summarize the current status of clinical trials using therapeutic cells produced from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). We also discuss combined cell and gene therapy via correction of defined mutations in human pluripotent stem ce...

journal_title：Current opinion in organ transplantation

authors： Angelos MG,Kaufman DS

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:High infectious risk donors (HRDs) fall into a behavioral category thought to increase risk of infectious transmission through transplantation; despite controversy surrounding their use, they comprise almost 9% of donors in which at least one organ is recovered. This review seeks to describe national ...

journal_title：Current opinion in organ transplantation

authors： Kucirka LM,Singer AL,Segev DL

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In spite of impressive improvements in short-term outcomes for intestine transplant recipients, late allograft loss continues to plague the field. Attention has mostly been focused on T-cell-mediated cellular mechanisms of allograft rejection to explain these losses; however, as in other forms of soli...

journal_title：Current opinion in organ transplantation

authors： Dick AA,Horslen S

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review emphasizes new information concerning the role of anaphylatoxins in the regulation of the immune response to allografts. Its timeliness relates the growing concept of the innate immune response as a regulator of the adaptive immune system and to how this concept lends itself to therapeutic...

journal_title：Current opinion in organ transplantation

authors： Sacks S,Lee Q,Wong W,Zhou W

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Cellular human antipig immune responses are increasingly recognized as an important barrier to successful clinical xenotransplantation. This review addresses the role of monocytes/macrophages, natural killer (NK) cells, and T cells in xenograft rejection. We focus on the receptor-ligand interactions t...

journal_title：Current opinion in organ transplantation

authors： Plege A,Schwinzer R

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation. RECENT FINDINGS:During an alloresponse, Toll-like receptors can be engaged by both damage-induced endogenous ligands or mi...

journal_title：Current opinion in organ transplantation

authors： Alegre ML,Goldstein DR,Chong AS

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

journal_title：Current opinion in organ transplantation

authors： Dunn TB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Exposure to noninherited maternal antigens (NIMAs) in fetal and neonatal life has life-long immunological consequences. Although there is a plethora of evidence of effects of mother on the immune responses of her offspring, there is very little knowledge available on how exposure to NIMA can result in...

journal_title：Current opinion in organ transplantation

authors： Dutta P,Burlingham WJ

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize current evidence supporting the existence of C4d-negative antibody-mediated rejection (AMR) in renal allografts, its potential to cause chronic graft injury, and whether histopathologic features of C4d-negative AMR differ from those of C4d-positive AMR. RECENT FINDINGS:Recently published...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequate insulin-producing pancreatic β-cell mass is a key feature of both type 1 and type 2 diabetes. Efforts to regenerate β-cell mass from pancreatic precursors may thus ameliorate absolute or relative insulin deficiency, thereby improving glucose homeostasis. A clear understanding of the process...

journal_title：Current opinion in organ transplantation

authors： Crutchlow MF,Stoffers DA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant number of kidney transplantations in industrialized countries is currently performed over human leukocyte antigen (HLA) or ABO antibody barriers after living donation to encounter the increasing shortage of organs from deceased donors. Although patients with moderate titers of anti-A/B a...

journal_title：Current opinion in organ transplantation

authors： Becker LE,Süsal C,Morath C

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Accurate measurement of human leukocyte antigen antibodies is critical for making clinical decisions treating patients awaiting transplantation or monitoring them post transplantation. Single antigen bead assay results are given as Mean Fluorescence Intensity, falling short of providing the required q...

journal_title：Current opinion in organ transplantation

authors： Maguire CH,Schinstock CA,Tambur AR

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Lungs are extremely susceptible to injury, and despite advances in surgical management and immunosuppression, outcomes for lung transplantation are the worst of any solid organ transplant. The success of lung transplantation is limited by high rates of primary graft dysfunction because of ischemia-rep...

journal_title：Current opinion in organ transplantation

authors： Laubach VE,Sharma AK

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular injury is a complex process that is central to the rejection of solid-organ xenografts in the preclinical pig-to-primate model of xenotransplantation. This review summarizes recent work that provides insights into the mechanisms of vascular injury in GalT KO pig xenografts. RECENT FINDINGS:S...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,Roussel JC,d'Apice AJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The first generation of implantable pulsatile ventricular assist devices (VADs) has proven to be successful as bridge to transplantation. Adverse events such as mechanical failure and infections, however, limit their use for long-term support (>1 year) or as alternative for heart transplantation. Newe...

journal_title：Current opinion in organ transplantation

authors： Lahpor JR

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The bidirectional exchange of cells, both mature and progenitor types, at the maternal-fetal interface is a common feature of mammalian reproduction. The presence of semiallogeneic cells in a host can have significant immunological effects on transplantation tolerance and rejection. Here, we review re...

journal_title：Current opinion in organ transplantation

authors： Dutta P,Burlingham WJ

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of everolimus has recently emerged for solid-organ transplantation in children. This review gives an overview of the relevant studies and clinical trials involving the immunosuppressive effects of everolimus in child organ transplant. RECENT FINDINGS:The use of everolimus in pediatric organ t...

journal_title：Current opinion in organ transplantation

authors： Pape L,Ganschow R,Ahlenstiel T

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the latest investigations into the role of frailty and assessment of other aging-related issues in the solid organ transplant candidate and recipient. This information is relevant for all involved in the care of transplant patients, but is especially relevant in infectious diseases, given ...

journal_title：Current opinion in organ transplantation

authors： Schaenman J,Goldwater D,Malinis M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute kidney failure in the perioperative liver transplant recipients results in an increased hospital length of stay, acute rejection, infection rate and overall mortality. Thus, it is of great importance to be able to recognize, prevent and treat kidney injury. RECENT FINDINGS:Immediate post liver ...

journal_title：Current opinion in organ transplantation

authors： Biancofiore G,Davis CL

更新日期：2008-06-01 00:00:00