Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment.

abstract：PURPOSE OF REVIEW:To provide an overview of how intravenous omega-3 fatty acids (O3FAs) have been used to prevent and treat pediatric intestinal failure-associated liver disease (IFALD). This review will introduce the most recent and relevant human and basic science data on the topic, and comment on how alterative lipi...

journal_title：Current opinion in organ transplantation

authors： Venick RS,Calkins K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of currently available immunosuppressive strategies and novel therapeutic developments in pancreas transplantation. RECENT FINDINGS:From 1966 through 2012 more than 30 000 pancreas transplantations have been performed around the world with excellent patient and graft survival. ...

journal_title：Current opinion in organ transplantation

authors： Kimelman M,Brandacher G

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical trials testing novel kidney transplant therapies are challenged by low rates of long-term clinical outcomes such as death and graft loss. Herein, we critically review traditional and more recent strategies to expedite new therapies by minimizing sample size and follow-up duration using surrog...

journal_title：Current opinion in organ transplantation

authors： Maggiore U,Leventhal J,Cravedi P

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The trend to extubate patients as soon as possible following large and complex surgery is supported by a large body of evidence showing early extubation is safe and saves money. However, the use of early extubation in liver transplant recipients is still debated. This review will explore the reasons w...

journal_title：Current opinion in organ transplantation

authors： Mandell MS,Campsen J,Zimmerman M,Biancofiore G,Tsou MY

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced ...

journal_title：Current opinion in organ transplantation

authors： Uriarte JJ,Uhl FE,Rolandsson Enes SE,Pouliot RA,Weiss DJ

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Although conceptually unchanged, the evaluation and selection of the liver transplant candidate has seen significant recent advances. Expanding criteria for transplant candidacy, improved diagnostics for risk stratification and advances in prognostic models have paralleled recent changes in allocation...

journal_title：Current opinion in organ transplantation

authors： Kriss M,Biggins SW

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:In this article, we will review the outcomes of patients with intestinal transplant (ITx) with a focus on factors affecting long-term graft and patient survival. RECENT FINDINGS:The most recent International Intestinal Transplant Registry reports a 1-, 5-, and 10-year graft survival of 71%, 50%, and ...

journal_title：Current opinion in organ transplantation

authors： Amin A,Farmer DG

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is still one of the major causes of death following heart transplantation. Here, we review the recent advances in its prevention and treatment. RECENT FINDINGS:Preventive measures comprise control of classical risk factors, prophylaxis against cytomegalovirus, avo...

journal_title：Current opinion in organ transplantation

authors： Crespo-Leiro MG,Marzoa-Rivas R,Barge-Caballero E,Paniagua-Martín MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart transplantation is the only curative treatment option for end-stage heart failure. However, a shortage of donor organs is a major limitation of this approach. Regenerative medicine targets the goal of increasing the number of available hearts for transplantation. In this review, we highlight the...

journal_title：Current opinion in organ transplantation

authors： Taylor DA,Elgalad A,Sampaio LC

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation is considered the optimal therapy for patients with insulin-dependent diabetes. Successful pancreas transplantation achieves euglycemia and allows freedom from insulin therapy. Long-term allograft success may be limited by the development of impaired glucose metabolism. The ob...

journal_title：Current opinion in organ transplantation

authors： Egidi MF,Lin A,Bratton CF,Baliga PK

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review features articles published during 2018 and 2019 regarding pediatric visceral transplantation in Europe. In this biannual review, the authors identify and summarize key articles pertinent to clinical and research areas. RECENT FINDINGS:There is a trend to a lower use of intestinal transpl...

journal_title：Current opinion in organ transplantation

authors： Andres AM,Ramos E,Hernandez F

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular injury is a complex process that is central to the rejection of solid-organ xenografts in the preclinical pig-to-primate model of xenotransplantation. This review summarizes recent work that provides insights into the mechanisms of vascular injury in GalT KO pig xenografts. RECENT FINDINGS:S...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,Roussel JC,d'Apice AJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequate insulin-producing pancreatic β-cell mass is a key feature of both type 1 and type 2 diabetes. Efforts to regenerate β-cell mass from pancreatic precursors may thus ameliorate absolute or relative insulin deficiency, thereby improving glucose homeostasis. A clear understanding of the process...

journal_title：Current opinion in organ transplantation

authors： Crutchlow MF,Stoffers DA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant shift in our understanding of the molecular and cellular basis for inflammatory bowel disease (IBD) mirrors research that has been ongoing in intestinal transplantation. The blurring of lines between these two disease states creates an avenue into potential therapeutic interventions whic...

journal_title：Current opinion in organ transplantation

authors： Belyayev L,Loh K,Fishbein TM,Kroemer A

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this chapter is to review the literature published in the past 10 years with focus to the best literatures published since 2015 regarding chronic hepatitis E virus (HEV) infection in patients who received solid organ transplantation. RECENT FINDINGS:Diagnosis of this disease relies pri...

journal_title：Current opinion in organ transplantation

authors： Fang SY,Han H

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the latest investigations into the role of frailty and assessment of other aging-related issues in the solid organ transplant candidate and recipient. This information is relevant for all involved in the care of transplant patients, but is especially relevant in infectious diseases, given ...

journal_title：Current opinion in organ transplantation

authors： Schaenman J,Goldwater D,Malinis M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organizat...

journal_title：Current opinion in organ transplantation

authors： Little MH,Takasato M

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Total pancreatectomy with islet autotransplantation (TPIAT) is a reliable therapy to retain endocrine function, to alleviate pain and improve quality of life in adult and pediatric patients suffering from refractory chronic pancreatitis and recurrent acute pancreatitis. Recently, an expansion of indic...

journal_title：Current opinion in organ transplantation

authors： Shindo Y,Kanak MA

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Porcine islet xenotransplantation into humans faces two major hurdles - safety issues related to xenosis and xenorejection of the transplants. The former has been overcome mainly by selection of a suitable disease-free source herd. RECENT FINDINGS:Four strategies have been employed to date to overcom...

journal_title：Current opinion in organ transplantation

authors： Elliott RB,Living Cell Technologies.

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation provides the only proven method to restore long-term normoglycemia in patients with insulin-dependent diabetes mellitus. Although many studies describe the most important risk factors for short-term survival of a pancreas transplant, more information about factors that disting...

journal_title：Current opinion in organ transplantation

authors： Gruessner AC,Gruessner RW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent practices and views regarding children as living organ donors in the USA. RECENT FINDINGS:Living donors have become an increasingly important source of organs for transplantation. Concern for the rights of donors has resulted in reconsideration of the use of minors as living organ...

journal_title：Current opinion in organ transplantation

authors： Olbrisch ME,Levenson JL,Newman JD

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart transplantation concomitant with a liver transplant may be warranted when end-stage heart failure results in irreversible liver failure. Previously reported outcomes have been excellent yet the specific immunoprotective role of the liver allograft is not known. We review the current literature a...

journal_title：Current opinion in organ transplantation

authors： Gong T,Hall S

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, there has been an increasing interest in nonhuman histocompatibility antigens as targets of injury in organ-transplant recipients. This increased interest has been spurred by the fact that human-histocompatibility-antigen-identical kidney transplants also undergo immunological r...

journal_title：Current opinion in organ transplantation

authors： Sumitran-Holgersson S

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade intestine transplantation has been accepted as standard therapy for patients with life-threatening complications of parenteral nutrition. For patients without life-threatening complications, continued therapy with parenteral nutrition has been standard despite seemingly similar pa...

journal_title：Current opinion in organ transplantation

authors： Sudan D

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

journal_title：Current opinion in organ transplantation

authors： Cetrulo CL Jr,Drijkoningen T,Sachs DH

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Extensive research in murine transplant models over the past two decades has convincingly demonstrated the ability of regulatory dendritic cells (DCregs) to promote long-term allograft survival. We review important considerations regarding the source of therapeutic DCregs (donor or recipient) and thei...

journal_title：Current opinion in organ transplantation

authors： Morelli AE,Thomson AW

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To define the natural history of kidney allograft loss related to recurrent diabetes following transplant, and to understand the potential benefit of pancreas transplantation upon kidney allograft survival. RECENT FINDINGS:A postulated benefit of simultaneous pancreas kidney transplant is that, unlik...

journal_title：Current opinion in organ transplantation

authors： Wiseman AC,Stites E,Kennealey P

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is the leading cause of late morbidity and mortality in heart transplant patients and limits long-term survival. Immunosuppression following cardiac transplantation has traditionally comprised a calcineurin inhibitor in combination with mycophenolate mofetil or aza...

journal_title：Current opinion in organ transplantation

authors： Raichlin E,Kushwaha SS

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In June 2011 the US Food and Drug Administration approved belatacept (Nulojix; Bristol-Myers Squibb, Princeton, New Jersey, USA) for the prophylaxis of organ rejection in adult kidney transplant recipients. This review will discuss the use of belatacept for the prevention of acute rejection as part of...

journal_title：Current opinion in organ transplantation

authors： Wojciechowski D,Vincenti F

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Inducible pluripotent stem (iPS) cells derived from somatic cells represent a novel renewable source of tissue precursors. The potential of iPS cells is considered to be at least equivalent to that of human embryonic stem cells, facilitating the treatment or cure of diseases such as diabetes mellitus,...

journal_title：Current opinion in organ transplantation

authors： Robbins RD,Prasain N,Maier BF,Yoder MC,Mirmira RG

更新日期：2010-02-01 00:00:00