Infections due to human herpesvirus 6 in solid organ transplant recipients.

abstract：PURPOSE OF REVIEW:There have been several recent articles which have attempted to refine the appropriate timing of listing for lung transplantation and the identification of factors which increase the risk with particular emphasis on pretransplant microbiology in patients with cystic fibrosis. Moreover, there are sever...

journal_title：Current opinion in organ transplantation

authors： Corris PA

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade intestine transplantation has been accepted as standard therapy for patients with life-threatening complications of parenteral nutrition. For patients without life-threatening complications, continued therapy with parenteral nutrition has been standard despite seemingly similar pa...

journal_title：Current opinion in organ transplantation

authors： Sudan D

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is the leading cause of late morbidity and mortality in heart transplant patients and limits long-term survival. Immunosuppression following cardiac transplantation has traditionally comprised a calcineurin inhibitor in combination with mycophenolate mofetil or aza...

journal_title：Current opinion in organ transplantation

authors： Raichlin E,Kushwaha SS

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize current evidence supporting the existence of C4d-negative antibody-mediated rejection (AMR) in renal allografts, its potential to cause chronic graft injury, and whether histopathologic features of C4d-negative AMR differ from those of C4d-positive AMR. RECENT FINDINGS:Recently published...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Pediatric kidney transplantation has made great strides over the preceding years. It has become an accepted and successful remedy for thousands of patients worldwide. For best outcomes, it must be viewed and treated as a distinct entity from adult transplantation with focus on the unique challenges pa...

journal_title：Current opinion in organ transplantation

authors： Etesami K,Lestz R,Hogen R

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights current outcomes in intestinal transplantation and summarizes advances that have recently occurred in five interrelated areas: progress in intestinal rehabilitation, immunologic and technical modifications, awareness of opportunities for improved allograft monitoring, and better...

journal_title：Current opinion in organ transplantation

authors： Mazariegos GV

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To introduce the updated Banff schema for antibody-mediated renal allograft rejection and related revisions to definitions within this schema agreed upon during and immediately subsequent to the 2013 Banff Conference on Allograft Pathology. RECENT FINDINGS:The original Banff schema for diagnosis of a...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Inducible pluripotent stem (iPS) cells derived from somatic cells represent a novel renewable source of tissue precursors. The potential of iPS cells is considered to be at least equivalent to that of human embryonic stem cells, facilitating the treatment or cure of diseases such as diabetes mellitus,...

journal_title：Current opinion in organ transplantation

authors： Robbins RD,Prasain N,Maier BF,Yoder MC,Mirmira RG

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressiv...

journal_title：Current opinion in organ transplantation

authors： Nunes-Cabaço H,Sousa AE

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Orthotopic liver transplant (OLT) is a major surgical procedure that can be both challenging and lengthy. One of the common findings in end-stage liver disease is renal failure, whether acute or chronic, which may complicate the intraoperative course. RECENT FINDINGS:The use of intraoperative hemodia...

journal_title：Current opinion in organ transplantation

authors： Sedra AH,Strum E

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Because the gap between liver organ supply and demand continues to increase, adult living-donor liver transplantation continues to represent a significant pool of organs. RECENT FINDINGS:With this in mind, we discuss recent issues in adult living-donor liver transplantation, including issues with don...

journal_title：Current opinion in organ transplantation

authors： Yeh H,Olthoff KM

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:B cells are known to play a central role in humoral immunity and to boost cellular immunity, however, in a variety of experimental models, B-cell subsets ameliorate inflammation and autoimmune disease, indicating that they can also play a regulatory role. Here, we highlight the advances in regulatory ...

journal_title：Current opinion in organ transplantation

authors： Kim JI,Rothstein DM,Markmann JF

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemic of obesity is having a marked impact on liver transplant candidates and recipients, and optimal approach for the obese liver transplant patient is not yet defined. The current review summarizes the role of bariatric surgery in obese liver transplant patients. RECENT FINDINGS:NASH is now ...

journal_title：Current opinion in organ transplantation

authors： Bonner K,Heimbach JK

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To deeply investigate one type of intracellular cardiac storage disease, the Fabry disease and one example of extracellular cardiac storage disease, the cardiac amyloidosis, with the aim to collect data about cardiac treatment at the end-stage level and the feasibility of heart transplantation (HTx) i...

journal_title：Current opinion in organ transplantation

authors： Di Nora C,Livi U

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Although living donor transplantation is considered an ethically acceptable undertaking for the purpose of saving another's life, its safety remains under investigation. RECENT FINDINGS:Although living donors undertake considerable medical risks for no direct medical benefit, the question remains whe...

journal_title：Current opinion in organ transplantation

authors： Gordon EJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The desire for biomarkers for diagnosis and prognosis of diseases has never been greater. With the availability of genome data and an increased availability of proteome data, the discovery of biomarkers has become increasingly feasible. This article reviews some recent applications of the many evolvin...

journal_title：Current opinion in organ transplantation

authors： Sarwal MM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Lung transplantation survival is still limited compared with other solid organ transplant modalities, due to a range of factors that are continuing to be elucidated. However, new research is emerging which indicates that the microbiome of the lungs, and of other organs, may have important implications...

journal_title：Current opinion in organ transplantation

authors： Mitchell AB

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

journal_title：Current opinion in organ transplantation

authors： Dunn TB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we summarize the current status of clinical trials using therapeutic cells produced from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). We also discuss combined cell and gene therapy via correction of defined mutations in human pluripotent stem ce...

journal_title：Current opinion in organ transplantation

authors： Angelos MG,Kaufman DS

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Extensive research in murine transplant models over the past two decades has convincingly demonstrated the ability of regulatory dendritic cells (DCregs) to promote long-term allograft survival. We review important considerations regarding the source of therapeutic DCregs (donor or recipient) and thei...

journal_title：Current opinion in organ transplantation

authors： Morelli AE,Thomson AW

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of nonheart-beating donors (NHBD), as a source for liver grafts, is the only way to objectively increase the activity in liver transplantation. Through the use of more strict criteria, 1-year graft survival has increased from 50% in initial series to 84-100%. With respect to type II NHBD (fail...

journal_title：Current opinion in organ transplantation

authors： García-Valdecasas JC,Fondevila C

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation is considered the optimal therapy for patients with insulin-dependent diabetes. Successful pancreas transplantation achieves euglycemia and allows freedom from insulin therapy. Long-term allograft success may be limited by the development of impaired glucose metabolism. The ob...

journal_title：Current opinion in organ transplantation

authors： Egidi MF,Lin A,Bratton CF,Baliga PK

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. This review focuses on recipient-derived infection. Recent data are reviewed that assess the susceptibility of porcine...

journal_title：Current opinion in organ transplantation

authors： Millard AL,Mueller NJ

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:New immunosuppressive agents have decreased the incidence of acute rejection rates without improvement in long-term outcomes. Drug toxicity due to a narrow therapeutic index and individual variations in pharmacokinetics and pharmacodynamics significantly contributes to the inferior outcomes. This revi...

journal_title：Current opinion in organ transplantation

authors： Wavamunno MD,Chapman JR

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent reports on whole pancreas and islet cell transplantation. It focuses on 'what the call to the future looks like' for both therapies as treatment options for those type 1 diabetes patients who do not respond well to conventional therapy. RECENT FINDINGS:The ...

journal_title：Current opinion in organ transplantation

authors： Vardanyan M,Parkin E,Gruessner C,Rodriguez Rilo HL

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascularized composite allograft (VCA) transplantation restores function and form following major soft tissue and musculoskeletal injury. Lifelong immunosuppression is necessary for graft function and survival but acute skin-targeted rejection episodes remain common. We review recent advances in skin ...

journal_title：Current opinion in organ transplantation

authors： Chadha R,Leonard DA,Kurtz JM,Cetrulo CL Jr

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Frailty is the concept of accumulating physiologic declines that make people less able to deal with stressors, including surgery. Prehabilitation is intervention to enhance functional capacity before surgery. Frailty and prehabilitation among transplant populations and the role of wearable fitness tra...

journal_title：Current opinion in organ transplantation

authors： Rumer KK,Saraswathula A,Melcher ML

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of how intravenous omega-3 fatty acids (O3FAs) have been used to prevent and treat pediatric intestinal failure-associated liver disease (IFALD). This review will introduce the most recent and relevant human and basic science data on the topic, and comment on how alterative lipi...

journal_title：Current opinion in organ transplantation

authors： Venick RS,Calkins K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is activated by interferon-gamma and via tryptophan depletion and the production of proapoptotic downstream metabolites IDO suppresses adaptive T-cell-mediated immunity in inflammation, host immune defence and maternal tolerance. In additio...

journal_title：Current opinion in organ transplantation

authors： Brandacher G,Margreiter R,Fuchs D

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Within the United States, donor heart and lung procurement varies between institutions and among surgeons within the same institution sometimes. The purpose of this article is to review the history of donor heart and lung procurement, the surgical techniques, and pitfalls. RECENT FINDINGS:The current...

journal_title：Current opinion in organ transplantation

authors： Copeland H,Copeland J,Hayanga JWA

更新日期：2018-06-01 00:00:00