An updated Banff schema for diagnosis of antibody-mediated rejection in renal allografts.

abstract：PURPOSE OF REVIEW:New immunosuppressive agents have decreased the incidence of acute rejection rates without improvement in long-term outcomes. Drug toxicity due to a narrow therapeutic index and individual variations in pharmacokinetics and pharmacodynamics significantly contributes to the inferior outcomes. This revi...

journal_title：Current opinion in organ transplantation

authors： Wavamunno MD,Chapman JR

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical trials testing novel kidney transplant therapies are challenged by low rates of long-term clinical outcomes such as death and graft loss. Herein, we critically review traditional and more recent strategies to expedite new therapies by minimizing sample size and follow-up duration using surrog...

journal_title：Current opinion in organ transplantation

authors： Maggiore U,Leventhal J,Cravedi P

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:In spite of impressive improvements in short-term outcomes for intestine transplant recipients, late allograft loss continues to plague the field. Attention has mostly been focused on T-cell-mediated cellular mechanisms of allograft rejection to explain these losses; however, as in other forms of soli...

journal_title：Current opinion in organ transplantation

authors： Dick AA,Horslen S

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Porcine islet xenotransplantation into humans faces two major hurdles - safety issues related to xenosis and xenorejection of the transplants. The former has been overcome mainly by selection of a suitable disease-free source herd. RECENT FINDINGS:Four strategies have been employed to date to overcom...

journal_title：Current opinion in organ transplantation

authors： Elliott RB,Living Cell Technologies.

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary graft failure, which represents one of the most frequent causes of early mortality, is mostly caused by ischemia-reperfusion injury (IRI). IRI may also induce rejection, which is the principal cause of mortality after transplantation. It is essential to understand the mechanism of pulmonary IR...

journal_title：Current opinion in organ transplantation

authors： Chen F,Date H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this chapter is to review the literature published in the past 10 years with focus to the best literatures published since 2015 regarding chronic hepatitis E virus (HEV) infection in patients who received solid organ transplantation. RECENT FINDINGS:Diagnosis of this disease relies pri...

journal_title：Current opinion in organ transplantation

authors： Fang SY,Han H

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute kidney failure in the perioperative liver transplant recipients results in an increased hospital length of stay, acute rejection, infection rate and overall mortality. Thus, it is of great importance to be able to recognize, prevent and treat kidney injury. RECENT FINDINGS:Immediate post liver ...

journal_title：Current opinion in organ transplantation

authors： Biancofiore G,Davis CL

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To deeply investigate one type of intracellular cardiac storage disease, the Fabry disease and one example of extracellular cardiac storage disease, the cardiac amyloidosis, with the aim to collect data about cardiac treatment at the end-stage level and the feasibility of heart transplantation (HTx) i...

journal_title：Current opinion in organ transplantation

authors： Di Nora C,Livi U

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence in literature regarding incidence and risk factors for biliary complications in living donor liver transplantation (LDLT), and current concepts in evaluation of donor biliary anatomy and surgical techniques of biliary reconstruction, to reduce the incidence of biliary comp...

journal_title：Current opinion in organ transplantation

authors： Bhangui P,Saha S

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplant recipients. This article provides a summary of the clinical research relating to donor-specific antibodies (DSA) and ABMR in kidney transplant recipients at the University of Wisconsin-Madison Transplant ...

journal_title：Current opinion in organ transplantation

authors： Garg N,Parajuli S,Mandelbrot DA,Djamali A

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation may become clinically feasible once the mechanisms of graft loss and rejection are better understood. Inflammatory reactions to vasculature of grafted pig organs and pancreatic islets have been linked to procoagulant activation and consumption with resulting thrombosis that preclud...

journal_title：Current opinion in organ transplantation

authors： Schmelzle M,Schulte Esch J 2nd,Robson SC

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Transplantation of islets of Langerhans is an emerging treatment procedure for patients with severe type 1 diabetes, but despite recent progress the procedure is associated with massive tissue loss caused by an inflammatory reaction termed instant blood-mediated inflammatory reaction (IBMIR). This rea...

journal_title：Current opinion in organ transplantation

authors： Nilsson B,Ekdahl KN,Korsgren O

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:There continues to be an inadequate organ supply and lack of effective temporary support, for patients with liver failure. The purpose of this review is to discuss recent progress in the field of orthotopic pig-to-nonhuman primate (NHP) liver xenotransplantation (LXT). RECENT FINDINGS:From 1968 to 20...

journal_title：Current opinion in organ transplantation

authors： Patel MS,Louras N,Vagefi PA

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Exposure to noninherited maternal antigens (NIMAs) in fetal and neonatal life has life-long immunological consequences. Although there is a plethora of evidence of effects of mother on the immune responses of her offspring, there is very little knowledge available on how exposure to NIMA can result in...

journal_title：Current opinion in organ transplantation

authors： Dutta P,Burlingham WJ

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent practices and views regarding children as living organ donors in the USA. RECENT FINDINGS:Living donors have become an increasingly important source of organs for transplantation. Concern for the rights of donors has resulted in reconsideration of the use of minors as living organ...

journal_title：Current opinion in organ transplantation

authors： Olbrisch ME,Levenson JL,Newman JD

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize current evidence supporting the existence of C4d-negative antibody-mediated rejection (AMR) in renal allografts, its potential to cause chronic graft injury, and whether histopathologic features of C4d-negative AMR differ from those of C4d-positive AMR. RECENT FINDINGS:Recently published...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Discuss the recent progress on the clinical use of mesenchymal stromal (stem) cells (MSC) in solid organ transplantation (SOT). RECENT FINDINGS:Tissue repair and immunomodulatory properties have been recognized for MSC obtained from different human tissues. MSC-based therapy has been proposed to redu...

journal_title：Current opinion in organ transplantation

authors： Pileggi A,Xu X,Tan J,Ricordi C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Manipulating costimulatory signals has been shown to alter T cell responses and prolong graft survival in solid organ transplantation. Our understanding of and ability to target various costimulation pathways continues to evolve. RECENT FINDINGS:Since the approval of belatacept in kidney transplantat...

journal_title：Current opinion in organ transplantation

authors： Schroder PM,Fitch ZW,Schmitz R,Choi AY,Kwun J,Knechtle SJ

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Organ shortage remains a major obstacle for liver transplantation, resulting in an increased mortality on the liver transplant waiting list. The usage of extended criteria donors (ECD) is a strategy to increase the number of available donor organs, however, with the risk of a higher rate of posttransp...

journal_title：Current opinion in organ transplantation

authors： Kollmann D,Selzner M

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Several expanded criteria for liver transplantation for hepatocellular carcinoma (HCC) have been suggested out of concern that the Milan criteria may be too strict, and thereby exclude patients who could benefit from this surgical procedure. However, most expanded criteria were designed for deceased d...

journal_title：Current opinion in organ transplantation

authors： Lee HW,Suh KS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organizat...

journal_title：Current opinion in organ transplantation

authors： Little MH,Takasato M

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of nonheart-beating donors (NHBD), as a source for liver grafts, is the only way to objectively increase the activity in liver transplantation. Through the use of more strict criteria, 1-year graft survival has increased from 50% in initial series to 84-100%. With respect to type II NHBD (fail...

journal_title：Current opinion in organ transplantation

authors： García-Valdecasas JC,Fondevila C

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune monitoring is needed in small bowel transplantation (SBTx) because of a high incidence of rejection and graft loss, and life-threatening complications of high-dose prophylactic immunosuppression. RECENT FINDINGS:Clinical tests relevant to SBTx include methods to detect antidonor human leukocyt...

journal_title：Current opinion in organ transplantation

authors： Sindhi R,AshokKumar C,Mazariegos G,Nayyar N,Ningappa M,Soltys K,Bond G,Sun Q,Humar A,Abu-Elmagd K,Zeevi A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Burgeoning literature on antibody-mediated rejection (ABMR) has led to a perception that T-cell-mediated rejection (TCMR) is no longer a significant problem. This premise needs to be carefully appraised. RECENT FINDINGS:A review of the literature indicates that TCMR remains an independent-risk factor...

journal_title：Current opinion in organ transplantation

authors： Randhawa P

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the scarcity of clinical trials with de-novo immunosuppression has been typical over the last 2 years, several attempts have been made in drug conversion, dosing optimization, and bioequivalence. On the basis of recent clinical and animal studies, future directions of management and treatment...

journal_title：Current opinion in organ transplantation

authors： Wohlfahrtova M,Viklicky O

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:There have been several recent articles which have attempted to refine the appropriate timing of listing for lung transplantation and the identification of factors which increase the risk with particular emphasis on pretransplant microbiology in patients with cystic fibrosis. Moreover, there are sever...

journal_title：Current opinion in organ transplantation

authors： Corris PA

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

journal_title：Current opinion in organ transplantation

authors： Cetrulo CL Jr,Drijkoningen T,Sachs DH

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Fulminant hepatic failure (FHF) is one of the more dramatic and challenging syndromes in clinical medicine. Time constraints and the scarcity of organs complicate the evaluation process in the case of patients presenting with FHF, raising ethical questions related to fairness and justice. The challeng...

journal_title：Current opinion in organ transplantation

authors： Appel J,Vaidya S

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Re-transplantation of the lung has come of age. Here, we wish to review the recent literature on the topic and discuss clinical implications. RECENT FINDINGS:Many large volume transplant centres routinely perform lung re-transplantation with satisfactory outcomes. The main indication is bronchiolitis...

journal_title：Current opinion in organ transplantation

authors： Warnecke G,Haverich A

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Frailty is the concept of accumulating physiologic declines that make people less able to deal with stressors, including surgery. Prehabilitation is intervention to enhance functional capacity before surgery. Frailty and prehabilitation among transplant populations and the role of wearable fitness tra...

journal_title：Current opinion in organ transplantation

authors： Rumer KK,Saraswathula A,Melcher ML

更新日期：2016-04-01 00:00:00