Pancreas vs. islet transplantation: a call on the future.

abstract：PURPOSE OF REVIEW:To outline recent studies describing the mechanisms of antibody-mediated rejection (AMR) and new clinical protocols aimed at prevention and/or treatment of this difficult clinical entity. RECENT FINDINGS:The natural history of acute AMR after positive cross-match kidney transplantation involves an ac...

journal_title：Current opinion in organ transplantation

authors： Stegall MD,Gloor JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of how intravenous omega-3 fatty acids (O3FAs) have been used to prevent and treat pediatric intestinal failure-associated liver disease (IFALD). This review will introduce the most recent and relevant human and basic science data on the topic, and comment on how alterative lipi...

journal_title：Current opinion in organ transplantation

authors： Venick RS,Calkins K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant number of kidney transplantations in industrialized countries is currently performed over human leukocyte antigen (HLA) or ABO antibody barriers after living donation to encounter the increasing shortage of organs from deceased donors. Although patients with moderate titers of anti-A/B a...

journal_title：Current opinion in organ transplantation

authors： Becker LE,Süsal C,Morath C

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The desire for biomarkers for diagnosis and prognosis of diseases has never been greater. With the availability of genome data and an increased availability of proteome data, the discovery of biomarkers has become increasingly feasible. This article reviews some recent applications of the many evolvin...

journal_title：Current opinion in organ transplantation

authors： Sarwal MM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review features articles published during 2018 and 2019 regarding pediatric visceral transplantation in Europe. In this biannual review, the authors identify and summarize key articles pertinent to clinical and research areas. RECENT FINDINGS:There is a trend to a lower use of intestinal transpl...

journal_title：Current opinion in organ transplantation

authors： Andres AM,Ramos E,Hernandez F

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Organ shortage in transplantation medicine forces surgical research toward the development of more efficient approaches in organ preservation to enable the application of 'less than optimal' grafts. This review summarizes current techniques aiming to recondition cold-stored organ grafts prior to trans...

journal_title：Current opinion in organ transplantation

authors： Minor T,von Horn C,Paul A

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In this article, we will review the outcomes of patients with intestinal transplant (ITx) with a focus on factors affecting long-term graft and patient survival. RECENT FINDINGS:The most recent International Intestinal Transplant Registry reports a 1-, 5-, and 10-year graft survival of 71%, 50%, and ...

journal_title：Current opinion in organ transplantation

authors： Amin A,Farmer DG

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the scarcity of clinical trials with de-novo immunosuppression has been typical over the last 2 years, several attempts have been made in drug conversion, dosing optimization, and bioequivalence. On the basis of recent clinical and animal studies, future directions of management and treatment...

journal_title：Current opinion in organ transplantation

authors： Wohlfahrtova M,Viklicky O

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Pneumonia occurs in 8-23% of patients after liver transplantation and contributes considerably to their morbidity and mortality. With the increasing acuity of liver transplantation patients in the current era, pneumonias, particularly ventilator-associated pneumonias, and multidrug-resistant pathogens...

journal_title：Current opinion in organ transplantation

authors： Angarita SAK,Russell TA,Kaldas FM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Re-transplantation of the lung has come of age. Here, we wish to review the recent literature on the topic and discuss clinical implications. RECENT FINDINGS:Many large volume transplant centres routinely perform lung re-transplantation with satisfactory outcomes. The main indication is bronchiolitis...

journal_title：Current opinion in organ transplantation

authors： Warnecke G,Haverich A

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the latest investigations into the role of frailty and assessment of other aging-related issues in the solid organ transplant candidate and recipient. This information is relevant for all involved in the care of transplant patients, but is especially relevant in infectious diseases, given ...

journal_title：Current opinion in organ transplantation

authors： Schaenman J,Goldwater D,Malinis M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplant recipients. This article provides a summary of the clinical research relating to donor-specific antibodies (DSA) and ABMR in kidney transplant recipients at the University of Wisconsin-Madison Transplant ...

journal_title：Current opinion in organ transplantation

authors： Garg N,Parajuli S,Mandelbrot DA,Djamali A

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Inducible pluripotent stem (iPS) cells derived from somatic cells represent a novel renewable source of tissue precursors. The potential of iPS cells is considered to be at least equivalent to that of human embryonic stem cells, facilitating the treatment or cure of diseases such as diabetes mellitus,...

journal_title：Current opinion in organ transplantation

authors： Robbins RD,Prasain N,Maier BF,Yoder MC,Mirmira RG

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To introduce the updated Banff schema for antibody-mediated renal allograft rejection and related revisions to definitions within this schema agreed upon during and immediately subsequent to the 2013 Banff Conference on Allograft Pathology. RECENT FINDINGS:The original Banff schema for diagnosis of a...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Macrophages are members of the innate immune response. However, their role in the adaptive immune response is not known. The purpose of this review is to highlight our current understanding of macrophage structure and function and how they may participate in allograft injury. RECENT FINDINGS:Studies ...

journal_title：Current opinion in organ transplantation

authors： Mannon RB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss the current state of donation after circulatory death (DCD). We define the DCD donor and describe the current protocols in management of the DCD patient. We then discuss current techniques in organ procurement of the lung and abdominal organs. RECENT FINDINGS:Although donat...

journal_title：Current opinion in organ transplantation

authors： Algahim MF,Love RB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Discuss the recent progress on the clinical use of mesenchymal stromal (stem) cells (MSC) in solid organ transplantation (SOT). RECENT FINDINGS:Tissue repair and immunomodulatory properties have been recognized for MSC obtained from different human tissues. MSC-based therapy has been proposed to redu...

journal_title：Current opinion in organ transplantation

authors： Pileggi A,Xu X,Tan J,Ricordi C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this chapter is to review the literature published in the past 10 years with focus to the best literatures published since 2015 regarding chronic hepatitis E virus (HEV) infection in patients who received solid organ transplantation. RECENT FINDINGS:Diagnosis of this disease relies pri...

journal_title：Current opinion in organ transplantation

authors： Fang SY,Han H

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is still one of the major causes of death following heart transplantation. Here, we review the recent advances in its prevention and treatment. RECENT FINDINGS:Preventive measures comprise control of classical risk factors, prophylaxis against cytomegalovirus, avo...

journal_title：Current opinion in organ transplantation

authors： Crespo-Leiro MG,Marzoa-Rivas R,Barge-Caballero E,Paniagua-Martín MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Ischaemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischaemia. This review discusses the components of innate immunity known to be involved in renal ischaemic reperfusion ...

journal_title：Current opinion in organ transplantation

authors： Cheung KP,Kasimsetty SG,McKay DB

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary antibody-mediated rejection (AMR) while contributing to acute and chronic allograft dysfunction remains a diagnostic and therapeutic challenge. The diagnostic tenets upon which AMR is defined will be reviewed in the light of recent studies. RECENT FINDINGS:The introduction of solid phase as...

journal_title：Current opinion in organ transplantation

authors： Westall GP,Paraskeva MA,Snell GI

更新日期：2015-10-01 00:00:00

abstract：:World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

journal_title：Current opinion in organ transplantation

authors： Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Living donation has a tremendous impact in bridging the gap between the shortage of organs and the growing list of transplant candidates but remains underutilized as a percentage of total transplants performed. This review focuses on obesity and social determinants of health as potential barriers to t...

journal_title：Current opinion in organ transplantation

authors： Kim J,Kim S,Genyk Y,Maw TT

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequate insulin-producing pancreatic β-cell mass is a key feature of both type 1 and type 2 diabetes. Efforts to regenerate β-cell mass from pancreatic precursors may thus ameliorate absolute or relative insulin deficiency, thereby improving glucose homeostasis. A clear understanding of the process...

journal_title：Current opinion in organ transplantation

authors： Crutchlow MF,Stoffers DA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Increased miniaturization of ventricular assist devices (VADs) and new mechanical support strategies (MCS) has increased the use of MCS in the pediatric and congenital heart disease (CHD) population. This comes with the need for care providers specialized in this field to determine optimal patient and...

journal_title：Current opinion in organ transplantation

authors： Schweiger M,Lorts A,Conway J

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Burgeoning literature on antibody-mediated rejection (ABMR) has led to a perception that T-cell-mediated rejection (TCMR) is no longer a significant problem. This premise needs to be carefully appraised. RECENT FINDINGS:A review of the literature indicates that TCMR remains an independent-risk factor...

journal_title：Current opinion in organ transplantation

authors： Randhawa P

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The bidirectional exchange of cells, both mature and progenitor types, at the maternal-fetal interface is a common feature of mammalian reproduction. The presence of semiallogeneic cells in a host can have significant immunological effects on transplantation tolerance and rejection. Here, we review re...

journal_title：Current opinion in organ transplantation

authors： Dutta P,Burlingham WJ

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular injury is a complex process that is central to the rejection of solid-organ xenografts in the preclinical pig-to-primate model of xenotransplantation. This review summarizes recent work that provides insights into the mechanisms of vascular injury in GalT KO pig xenografts. RECENT FINDINGS:S...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,Roussel JC,d'Apice AJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Orthotopic liver transplant (OLT) is a major surgical procedure that can be both challenging and lengthy. One of the common findings in end-stage liver disease is renal failure, whether acute or chronic, which may complicate the intraoperative course. RECENT FINDINGS:The use of intraoperative hemodia...

journal_title：Current opinion in organ transplantation

authors： Sedra AH,Strum E

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressiv...

journal_title：Current opinion in organ transplantation

authors： Nunes-Cabaço H,Sousa AE

更新日期：2013-06-01 00:00:00