Innate immunity in donor procurement.

abstract：PURPOSE OF REVIEW:Living donation has a tremendous impact in bridging the gap between the shortage of organs and the growing list of transplant candidates but remains underutilized as a percentage of total transplants performed. This review focuses on obesity and social determinants of health as potential barriers to t...

journal_title：Current opinion in organ transplantation

authors： Kim J,Kim S,Genyk Y,Maw TT

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequate insulin-producing pancreatic β-cell mass is a key feature of both type 1 and type 2 diabetes. Efforts to regenerate β-cell mass from pancreatic precursors may thus ameliorate absolute or relative insulin deficiency, thereby improving glucose homeostasis. A clear understanding of the process...

journal_title：Current opinion in organ transplantation

authors： Crutchlow MF,Stoffers DA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunological tolerance has long been considered the 'holy grail' of organ transplantation. Although tolerance has been an active area of research for 70 years, its clinical application has only been possible in the last two decades and widespread use remains an, as yet, unattained goal. Recent advanc...

journal_title：Current opinion in organ transplantation

authors： Rickert CG,Markmann JF

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To give a comprehensive overview of the recently published studies on the role of the lectin pathway in coagulation, infections and auto-immunity. RECENT FINDINGS:We present the status quo picture of the lectin pathway, including the newly discovered member, MAp44 (a.k.a. MAP-1), which may act as a s...

journal_title：Current opinion in organ transplantation

authors： Degn SE,Jensenius JC,Bjerre M

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:New immunosuppressive agents have decreased the incidence of acute rejection rates without improvement in long-term outcomes. Drug toxicity due to a narrow therapeutic index and individual variations in pharmacokinetics and pharmacodynamics significantly contributes to the inferior outcomes. This revi...

journal_title：Current opinion in organ transplantation

authors： Wavamunno MD,Chapman JR

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute kidney failure in the perioperative liver transplant recipients results in an increased hospital length of stay, acute rejection, infection rate and overall mortality. Thus, it is of great importance to be able to recognize, prevent and treat kidney injury. RECENT FINDINGS:Immediate post liver ...

journal_title：Current opinion in organ transplantation

authors： Biancofiore G,Davis CL

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the experience to date and unique challenges associated with liver transplantation in hepatitis C virus (HCV)/HIV-coinfected patients. RECENT FINDINGS:The prevalence of cirrhosis and hepatocellular carcinoma is rising among HIV-infected individuals. With careful patient selection and in the...

journal_title：Current opinion in organ transplantation

authors： Kardashian AA,Price JC

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary graft failure, which represents one of the most frequent causes of early mortality, is mostly caused by ischemia-reperfusion injury (IRI). IRI may also induce rejection, which is the principal cause of mortality after transplantation. It is essential to understand the mechanism of pulmonary IR...

journal_title：Current opinion in organ transplantation

authors： Chen F,Date H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary hypertension patients provide challenging issues to anesthesiology. The condition is more so when it is associated with liver transplant surgery. This situation is especially true when associated with portopulmonary hypertension (POPH), a subdivision of pulmonary hypertension. Understanding ...

journal_title：Current opinion in organ transplantation

authors： Ayoub T

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Pediatric kidney transplantation has made great strides over the preceding years. It has become an accepted and successful remedy for thousands of patients worldwide. For best outcomes, it must be viewed and treated as a distinct entity from adult transplantation with focus on the unique challenges pa...

journal_title：Current opinion in organ transplantation

authors： Etesami K,Lestz R,Hogen R

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. This review focuses on recipient-derived infection. Recent data are reviewed that assess the susceptibility of porcine...

journal_title：Current opinion in organ transplantation

authors： Millard AL,Mueller NJ

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The first generation of implantable pulsatile ventricular assist devices (VADs) has proven to be successful as bridge to transplantation. Adverse events such as mechanical failure and infections, however, limit their use for long-term support (>1 year) or as alternative for heart transplantation. Newe...

journal_title：Current opinion in organ transplantation

authors： Lahpor JR

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent reports on whole pancreas and islet cell transplantation. It focuses on 'what the call to the future looks like' for both therapies as treatment options for those type 1 diabetes patients who do not respond well to conventional therapy. RECENT FINDINGS:The ...

journal_title：Current opinion in organ transplantation

authors： Vardanyan M,Parkin E,Gruessner C,Rodriguez Rilo HL

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:In this article, we will review the outcomes of patients with intestinal transplant (ITx) with a focus on factors affecting long-term graft and patient survival. RECENT FINDINGS:The most recent International Intestinal Transplant Registry reports a 1-, 5-, and 10-year graft survival of 71%, 50%, and ...

journal_title：Current opinion in organ transplantation

authors： Amin A,Farmer DG

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Lung transplantation survival is still limited compared with other solid organ transplant modalities, due to a range of factors that are continuing to be elucidated. However, new research is emerging which indicates that the microbiome of the lungs, and of other organs, may have important implications...

journal_title：Current opinion in organ transplantation

authors： Mitchell AB

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

journal_title：Current opinion in organ transplantation

authors： Cetrulo CL Jr,Drijkoningen T,Sachs DH

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant shift in our understanding of the molecular and cellular basis for inflammatory bowel disease (IBD) mirrors research that has been ongoing in intestinal transplantation. The blurring of lines between these two disease states creates an avenue into potential therapeutic interventions whic...

journal_title：Current opinion in organ transplantation

authors： Belyayev L,Loh K,Fishbein TM,Kroemer A

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the latest investigations into the role of frailty and assessment of other aging-related issues in the solid organ transplant candidate and recipient. This information is relevant for all involved in the care of transplant patients, but is especially relevant in infectious diseases, given ...

journal_title：Current opinion in organ transplantation

authors： Schaenman J,Goldwater D,Malinis M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Although conceptually unchanged, the evaluation and selection of the liver transplant candidate has seen significant recent advances. Expanding criteria for transplant candidacy, improved diagnostics for risk stratification and advances in prognostic models have paralleled recent changes in allocation...

journal_title：Current opinion in organ transplantation

authors： Kriss M,Biggins SW

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights current outcomes in intestinal transplantation and summarizes advances that have recently occurred in five interrelated areas: progress in intestinal rehabilitation, immunologic and technical modifications, awareness of opportunities for improved allograft monitoring, and better...

journal_title：Current opinion in organ transplantation

authors： Mazariegos GV

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced ...

journal_title：Current opinion in organ transplantation

authors： Uriarte JJ,Uhl FE,Rolandsson Enes SE,Pouliot RA,Weiss DJ

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation provides the only proven method to restore long-term normoglycemia in patients with insulin-dependent diabetes mellitus. Although many studies describe the most important risk factors for short-term survival of a pancreas transplant, more information about factors that disting...

journal_title：Current opinion in organ transplantation

authors： Gruessner AC,Gruessner RW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To introduce the updated Banff schema for antibody-mediated renal allograft rejection and related revisions to definitions within this schema agreed upon during and immediately subsequent to the 2013 Banff Conference on Allograft Pathology. RECENT FINDINGS:The original Banff schema for diagnosis of a...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Cellular human antipig immune responses are increasingly recognized as an important barrier to successful clinical xenotransplantation. This review addresses the role of monocytes/macrophages, natural killer (NK) cells, and T cells in xenograft rejection. We focus on the receptor-ligand interactions t...

journal_title：Current opinion in organ transplantation

authors： Plege A,Schwinzer R

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the complex interplay between the microbiota and host immune responses, and its impact on intestinal transplantation and allograft rejection. RECENT FINDINGS:Recent findings highlight the importance of Paneth cells as crucial producers of antimicrobial peptides that control th...

journal_title：Current opinion in organ transplantation

authors： Kroemer A,Elsabbagh AM,Matsumoto CS,Zasloff M,Fishbein TM

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplant recipients. This article provides a summary of the clinical research relating to donor-specific antibodies (DSA) and ABMR in kidney transplant recipients at the University of Wisconsin-Madison Transplant ...

journal_title：Current opinion in organ transplantation

authors： Garg N,Parajuli S,Mandelbrot DA,Djamali A

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation. RECENT FINDINGS:During an alloresponse, Toll-like receptors can be engaged by both damage-induced endogenous ligands or mi...

journal_title：Current opinion in organ transplantation

authors： Alegre ML,Goldstein DR,Chong AS

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is activated by interferon-gamma and via tryptophan depletion and the production of proapoptotic downstream metabolites IDO suppresses adaptive T-cell-mediated immunity in inflammation, host immune defence and maternal tolerance. In additio...

journal_title：Current opinion in organ transplantation

authors： Brandacher G,Margreiter R,Fuchs D

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Geographic variation in liver transplantation has been the subject of extensive scrutiny, reflecting concerns that location is unfairly determinative for people needing organ transplantation. Drawing upon a number of established ethical approaches, we examine whether geographic differences in access t...

journal_title：Current opinion in organ transplantation

authors： Ladin K,Hanto DW

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart transplantation is the only curative treatment option for end-stage heart failure. However, a shortage of donor organs is a major limitation of this approach. Regenerative medicine targets the goal of increasing the number of available hearts for transplantation. In this review, we highlight the...

journal_title：Current opinion in organ transplantation

authors： Taylor DA,Elgalad A,Sampaio LC

更新日期：2018-12-01 00:00:00