The parallel paradigm between intestinal transplant inflammation and inflammatory bowel disease.

abstract：PURPOSE OF REVIEW:Extensive research in murine transplant models over the past two decades has convincingly demonstrated the ability of regulatory dendritic cells (DCregs) to promote long-term allograft survival. We review important considerations regarding the source of therapeutic DCregs (donor or recipient) and thei...

journal_title：Current opinion in organ transplantation

authors： Morelli AE,Thomson AW

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of T-cell exhaustion in the failure of clearance of viral infections and tumors is well established. There are several ongoing trials to reverse T-cell exhaustion for treatment of chronic viral infections and tumors. The mechanisms leading to T-cell exhaustion and its role in transplantation,...

journal_title：Current opinion in organ transplantation

authors： Thorp EB,Stehlik C,Ansari MJ

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemic of obesity is having a marked impact on liver transplant candidates and recipients, and optimal approach for the obese liver transplant patient is not yet defined. The current review summarizes the role of bariatric surgery in obese liver transplant patients. RECENT FINDINGS:NASH is now ...

journal_title：Current opinion in organ transplantation

authors： Bonner K,Heimbach JK

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation is considered the optimal therapy for patients with insulin-dependent diabetes. Successful pancreas transplantation achieves euglycemia and allows freedom from insulin therapy. Long-term allograft success may be limited by the development of impaired glucose metabolism. The ob...

journal_title：Current opinion in organ transplantation

authors： Egidi MF,Lin A,Bratton CF,Baliga PK

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary antibody-mediated rejection (AMR) while contributing to acute and chronic allograft dysfunction remains a diagnostic and therapeutic challenge. The diagnostic tenets upon which AMR is defined will be reviewed in the light of recent studies. RECENT FINDINGS:The introduction of solid phase as...

journal_title：Current opinion in organ transplantation

authors： Westall GP,Paraskeva MA,Snell GI

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

journal_title：Current opinion in organ transplantation

authors： Dunn TB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute and chronic kidney disease is a leading cause of morbidity and mortality worldwide with overall mortality rates between 50 and 80%. An acute shortage of compatible organs coupled with limited adaptability of current dialysis techniques has created a sense of urgency to investigate new alternativ...

journal_title：Current opinion in organ transplantation

authors： Chhabra P,Brayman KL

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Pneumonia occurs in 8-23% of patients after liver transplantation and contributes considerably to their morbidity and mortality. With the increasing acuity of liver transplantation patients in the current era, pneumonias, particularly ventilator-associated pneumonias, and multidrug-resistant pathogens...

journal_title：Current opinion in organ transplantation

authors： Angarita SAK,Russell TA,Kaldas FM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of how intravenous omega-3 fatty acids (O3FAs) have been used to prevent and treat pediatric intestinal failure-associated liver disease (IFALD). This review will introduce the most recent and relevant human and basic science data on the topic, and comment on how alterative lipi...

journal_title：Current opinion in organ transplantation

authors： Venick RS,Calkins K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Cellular human antipig immune responses are increasingly recognized as an important barrier to successful clinical xenotransplantation. This review addresses the role of monocytes/macrophages, natural killer (NK) cells, and T cells in xenograft rejection. We focus on the receptor-ligand interactions t...

journal_title：Current opinion in organ transplantation

authors： Plege A,Schwinzer R

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current understanding of the ethical and societal difficulties of penile transplantation. RECENT FINDINGS:Penile transplantation, as with other forms of vascularized composite allotransplantation, has increasing acceptance in society but is still not entirely accepted. Guidelines aiming...

journal_title：Current opinion in organ transplantation

authors： van der Merwe A,Moosa MR,Barsdorf N

更新日期：2020-12-01 00:00:00

abstract：:World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

journal_title：Current opinion in organ transplantation

authors： Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Pediatric kidney transplantation has made great strides over the preceding years. It has become an accepted and successful remedy for thousands of patients worldwide. For best outcomes, it must be viewed and treated as a distinct entity from adult transplantation with focus on the unique challenges pa...

journal_title：Current opinion in organ transplantation

authors： Etesami K,Lestz R,Hogen R

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Discuss the recent progress on the clinical use of mesenchymal stromal (stem) cells (MSC) in solid organ transplantation (SOT). RECENT FINDINGS:Tissue repair and immunomodulatory properties have been recognized for MSC obtained from different human tissues. MSC-based therapy has been proposed to redu...

journal_title：Current opinion in organ transplantation

authors： Pileggi A,Xu X,Tan J,Ricordi C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss the current state of donation after circulatory death (DCD). We define the DCD donor and describe the current protocols in management of the DCD patient. We then discuss current techniques in organ procurement of the lung and abdominal organs. RECENT FINDINGS:Although donat...

journal_title：Current opinion in organ transplantation

authors： Algahim MF,Love RB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the experience to date and unique challenges associated with liver transplantation in hepatitis C virus (HCV)/HIV-coinfected patients. RECENT FINDINGS:The prevalence of cirrhosis and hepatocellular carcinoma is rising among HIV-infected individuals. With careful patient selection and in the...

journal_title：Current opinion in organ transplantation

authors： Kardashian AA,Price JC

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, there has been an increasing interest in nonhuman histocompatibility antigens as targets of injury in organ-transplant recipients. This increased interest has been spurred by the fact that human-histocompatibility-antigen-identical kidney transplants also undergo immunological r...

journal_title：Current opinion in organ transplantation

authors： Sumitran-Holgersson S

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Travel-related diseases may be seen in transplant recipients after travel, after transplant tourism, and via transmission from blood and organ donors, augmented by recent increases in travel, migration, and globalization. Such infections include tuberculosis, Plasmodium (malaria), Babesia, Trypanosoma...

journal_title：Current opinion in organ transplantation

authors： Kotton CN

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights current outcomes in intestinal transplantation and summarizes advances that have recently occurred in five interrelated areas: progress in intestinal rehabilitation, immunologic and technical modifications, awareness of opportunities for improved allograft monitoring, and better...

journal_title：Current opinion in organ transplantation

authors： Mazariegos GV

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Increased miniaturization of ventricular assist devices (VADs) and new mechanical support strategies (MCS) has increased the use of MCS in the pediatric and congenital heart disease (CHD) population. This comes with the need for care providers specialized in this field to determine optimal patient and...

journal_title：Current opinion in organ transplantation

authors： Schweiger M,Lorts A,Conway J

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Islet transplantation has made great progress in recent years. This is a remarkable technical feat but raises the question of what the long-term benefits and risks are for type I diabetes recipients. RECENT FINDINGS:Graft survival continues to improve, and recent multicenter studies show that islet t...

journal_title：Current opinion in organ transplantation

authors： Holmes-Walker DJ,Kay TW

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Total pancreatectomy with islet autotransplantation (TPIAT) is a reliable therapy to retain endocrine function, to alleviate pain and improve quality of life in adult and pediatric patients suffering from refractory chronic pancreatitis and recurrent acute pancreatitis. Recently, an expansion of indic...

journal_title：Current opinion in organ transplantation

authors： Shindo Y,Kanak MA

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Frailty is the concept of accumulating physiologic declines that make people less able to deal with stressors, including surgery. Prehabilitation is intervention to enhance functional capacity before surgery. Frailty and prehabilitation among transplant populations and the role of wearable fitness tra...

journal_title：Current opinion in organ transplantation

authors： Rumer KK,Saraswathula A,Melcher ML

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is activated by interferon-gamma and via tryptophan depletion and the production of proapoptotic downstream metabolites IDO suppresses adaptive T-cell-mediated immunity in inflammation, host immune defence and maternal tolerance. In additio...

journal_title：Current opinion in organ transplantation

authors： Brandacher G,Margreiter R,Fuchs D

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Donor-derived disease with Mycobacterium tuberculosis (MTB) is likely to become more common as donor pools expand due to increasing transplant volume coupled with patterns of migration and global mobility. Our article reviews the current literature and provides a rational approach for clinicians manag...

journal_title：Current opinion in organ transplantation

authors： Gibb J,Wong D

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Orthotopic liver transplant (OLT) is a major surgical procedure that can be both challenging and lengthy. One of the common findings in end-stage liver disease is renal failure, whether acute or chronic, which may complicate the intraoperative course. RECENT FINDINGS:The use of intraoperative hemodia...

journal_title：Current opinion in organ transplantation

authors： Sedra AH,Strum E

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent reports on whole pancreas and islet cell transplantation. It focuses on 'what the call to the future looks like' for both therapies as treatment options for those type 1 diabetes patients who do not respond well to conventional therapy. RECENT FINDINGS:The ...

journal_title：Current opinion in organ transplantation

authors： Vardanyan M,Parkin E,Gruessner C,Rodriguez Rilo HL

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular injury is a complex process that is central to the rejection of solid-organ xenografts in the preclinical pig-to-primate model of xenotransplantation. This review summarizes recent work that provides insights into the mechanisms of vascular injury in GalT KO pig xenografts. RECENT FINDINGS:S...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,Roussel JC,d'Apice AJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Because the gap between liver organ supply and demand continues to increase, adult living-donor liver transplantation continues to represent a significant pool of organs. RECENT FINDINGS:With this in mind, we discuss recent issues in adult living-donor liver transplantation, including issues with don...

journal_title：Current opinion in organ transplantation

authors： Yeh H,Olthoff KM

更新日期：2008-06-01 00:00:00