Macrophages: contributors to allograft dysfunction, repair, or innocent bystanders?

abstract：PURPOSE OF REVIEW:Primary graft failure, which represents one of the most frequent causes of early mortality, is mostly caused by ischemia-reperfusion injury (IRI). IRI may also induce rejection, which is the principal cause of mortality after transplantation. It is essential to understand the mechanism of pulmonary IR...

journal_title：Current opinion in organ transplantation

authors： Chen F,Date H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review emphasizes new information concerning the role of anaphylatoxins in the regulation of the immune response to allografts. Its timeliness relates the growing concept of the innate immune response as a regulator of the adaptive immune system and to how this concept lends itself to therapeutic...

journal_title：Current opinion in organ transplantation

authors： Sacks S,Lee Q,Wong W,Zhou W

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Pediatric kidney transplantation has made great strides over the preceding years. It has become an accepted and successful remedy for thousands of patients worldwide. For best outcomes, it must be viewed and treated as a distinct entity from adult transplantation with focus on the unique challenges pa...

journal_title：Current opinion in organ transplantation

authors： Etesami K,Lestz R,Hogen R

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To deeply investigate one type of intracellular cardiac storage disease, the Fabry disease and one example of extracellular cardiac storage disease, the cardiac amyloidosis, with the aim to collect data about cardiac treatment at the end-stage level and the feasibility of heart transplantation (HTx) i...

journal_title：Current opinion in organ transplantation

authors： Di Nora C,Livi U

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of everolimus has recently emerged for solid-organ transplantation in children. This review gives an overview of the relevant studies and clinical trials involving the immunosuppressive effects of everolimus in child organ transplant. RECENT FINDINGS:The use of everolimus in pediatric organ t...

journal_title：Current opinion in organ transplantation

authors： Pape L,Ganschow R,Ahlenstiel T

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascularized composite allograft (VCA) transplantation restores function and form following major soft tissue and musculoskeletal injury. Lifelong immunosuppression is necessary for graft function and survival but acute skin-targeted rejection episodes remain common. We review recent advances in skin ...

journal_title：Current opinion in organ transplantation

authors： Chadha R,Leonard DA,Kurtz JM,Cetrulo CL Jr

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Pneumonia occurs in 8-23% of patients after liver transplantation and contributes considerably to their morbidity and mortality. With the increasing acuity of liver transplantation patients in the current era, pneumonias, particularly ventilator-associated pneumonias, and multidrug-resistant pathogens...

journal_title：Current opinion in organ transplantation

authors： Angarita SAK,Russell TA,Kaldas FM

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of currently available immunosuppressive strategies and novel therapeutic developments in pancreas transplantation. RECENT FINDINGS:From 1966 through 2012 more than 30 000 pancreas transplantations have been performed around the world with excellent patient and graft survival. ...

journal_title：Current opinion in organ transplantation

authors： Kimelman M,Brandacher G

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current understanding of the ethical and societal difficulties of penile transplantation. RECENT FINDINGS:Penile transplantation, as with other forms of vascularized composite allotransplantation, has increasing acceptance in society but is still not entirely accepted. Guidelines aiming...

journal_title：Current opinion in organ transplantation

authors： van der Merwe A,Moosa MR,Barsdorf N

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Several expanded criteria for liver transplantation for hepatocellular carcinoma (HCC) have been suggested out of concern that the Milan criteria may be too strict, and thereby exclude patients who could benefit from this surgical procedure. However, most expanded criteria were designed for deceased d...

journal_title：Current opinion in organ transplantation

authors： Lee HW,Suh KS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular injury is a complex process that is central to the rejection of solid-organ xenografts in the preclinical pig-to-primate model of xenotransplantation. This review summarizes recent work that provides insights into the mechanisms of vascular injury in GalT KO pig xenografts. RECENT FINDINGS:S...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,Roussel JC,d'Apice AJ

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:B cells are known to play a central role in humoral immunity and to boost cellular immunity, however, in a variety of experimental models, B-cell subsets ameliorate inflammation and autoimmune disease, indicating that they can also play a regulatory role. Here, we highlight the advances in regulatory ...

journal_title：Current opinion in organ transplantation

authors： Kim JI,Rothstein DM,Markmann JF

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Although living donor transplantation is considered an ethically acceptable undertaking for the purpose of saving another's life, its safety remains under investigation. RECENT FINDINGS:Although living donors undertake considerable medical risks for no direct medical benefit, the question remains whe...

journal_title：Current opinion in organ transplantation

authors： Gordon EJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant shift in our understanding of the molecular and cellular basis for inflammatory bowel disease (IBD) mirrors research that has been ongoing in intestinal transplantation. The blurring of lines between these two disease states creates an avenue into potential therapeutic interventions whic...

journal_title：Current opinion in organ transplantation

authors： Belyayev L,Loh K,Fishbein TM,Kroemer A

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Total pancreatectomy with islet autotransplantation (TPIAT) is a reliable therapy to retain endocrine function, to alleviate pain and improve quality of life in adult and pediatric patients suffering from refractory chronic pancreatitis and recurrent acute pancreatitis. Recently, an expansion of indic...

journal_title：Current opinion in organ transplantation

authors： Shindo Y,Kanak MA

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The first generation of implantable pulsatile ventricular assist devices (VADs) has proven to be successful as bridge to transplantation. Adverse events such as mechanical failure and infections, however, limit their use for long-term support (>1 year) or as alternative for heart transplantation. Newe...

journal_title：Current opinion in organ transplantation

authors： Lahpor JR

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequate insulin-producing pancreatic β-cell mass is a key feature of both type 1 and type 2 diabetes. Efforts to regenerate β-cell mass from pancreatic precursors may thus ameliorate absolute or relative insulin deficiency, thereby improving glucose homeostasis. A clear understanding of the process...

journal_title：Current opinion in organ transplantation

authors： Crutchlow MF,Stoffers DA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of nonheart-beating donors (NHBD), as a source for liver grafts, is the only way to objectively increase the activity in liver transplantation. Through the use of more strict criteria, 1-year graft survival has increased from 50% in initial series to 84-100%. With respect to type II NHBD (fail...

journal_title：Current opinion in organ transplantation

authors： García-Valdecasas JC,Fondevila C

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Transplantation of islets of Langerhans is an emerging treatment procedure for patients with severe type 1 diabetes, but despite recent progress the procedure is associated with massive tissue loss caused by an inflammatory reaction termed instant blood-mediated inflammatory reaction (IBMIR). This rea...

journal_title：Current opinion in organ transplantation

authors： Nilsson B,Ekdahl KN,Korsgren O

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of sensitized heart transplant candidates is rising. Highly sensitized patients are disadvantaged because they encounter longer waiting times to heart transplant. Strategies to reduce their waiting times include waitlist prioritization and desensitization therapies. The purpose of this revi...

journal_title：Current opinion in organ transplantation

authors： Aleksova N,Ross HJ

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of T-cell exhaustion in the failure of clearance of viral infections and tumors is well established. There are several ongoing trials to reverse T-cell exhaustion for treatment of chronic viral infections and tumors. The mechanisms leading to T-cell exhaustion and its role in transplantation,...

journal_title：Current opinion in organ transplantation

authors： Thorp EB,Stehlik C,Ansari MJ

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent practices and views regarding children as living organ donors in the USA. RECENT FINDINGS:Living donors have become an increasingly important source of organs for transplantation. Concern for the rights of donors has resulted in reconsideration of the use of minors as living organ...

journal_title：Current opinion in organ transplantation

authors： Olbrisch ME,Levenson JL,Newman JD

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical trials testing novel kidney transplant therapies are challenged by low rates of long-term clinical outcomes such as death and graft loss. Herein, we critically review traditional and more recent strategies to expedite new therapies by minimizing sample size and follow-up duration using surrog...

journal_title：Current opinion in organ transplantation

authors： Maggiore U,Leventhal J,Cravedi P

更新日期：2020-02-01 00:00:00

abstract：:World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

journal_title：Current opinion in organ transplantation

authors： Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. This review focuses on recipient-derived infection. Recent data are reviewed that assess the susceptibility of porcine...

journal_title：Current opinion in organ transplantation

authors： Millard AL,Mueller NJ

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Organ shortage remains a major obstacle for liver transplantation, resulting in an increased mortality on the liver transplant waiting list. The usage of extended criteria donors (ECD) is a strategy to increase the number of available donor organs, however, with the risk of a higher rate of posttransp...

journal_title：Current opinion in organ transplantation

authors： Kollmann D,Selzner M

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Increased miniaturization of ventricular assist devices (VADs) and new mechanical support strategies (MCS) has increased the use of MCS in the pediatric and congenital heart disease (CHD) population. This comes with the need for care providers specialized in this field to determine optimal patient and...

journal_title：Current opinion in organ transplantation

authors： Schweiger M,Lorts A,Conway J

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation is considered the optimal therapy for patients with insulin-dependent diabetes. Successful pancreas transplantation achieves euglycemia and allows freedom from insulin therapy. Long-term allograft success may be limited by the development of impaired glucose metabolism. The ob...

journal_title：Current opinion in organ transplantation

authors： Egidi MF,Lin A,Bratton CF,Baliga PK

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Ischaemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischaemia. This review discusses the components of innate immunity known to be involved in renal ischaemic reperfusion ...

journal_title：Current opinion in organ transplantation

authors： Cheung KP,Kasimsetty SG,McKay DB

更新日期：2013-04-01 00:00:00