Everolimus in pediatric transplantation.

Abstract:

PURPOSE OF REVIEW:The use of everolimus has recently emerged for solid-organ transplantation in children. This review gives an overview of the relevant studies and clinical trials involving the immunosuppressive effects of everolimus in child organ transplant. RECENT FINDINGS:The use of everolimus in pediatric organ transplantation is associated with a decrease in calcineurin inhibitor-related toxicity, better renal function, a low number of acute rejections, and an acceptable side-effect profile. Particularly, the use of everolimus reduces the incidence of virus infection and the risk of posttransplant lymphoproliferative disease. SUMMARY:Everolimus is an effective agent with several advantages for pediatric solid-organ transplantation. Future prospective, randomized controlled trials will have to be performed in order to validate the findings of these pilot trials.

authors

Pape L,Ganschow R,Ahlenstiel T

doi

10.1097/MOT.0b013e328356b080

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

515-9

issue

5

eissn

1087-2418

issn

1531-7013

journal_volume

17

pub_type

杂志文章,评审
  • Trends in immunosuppression after pancreas transplantation: what is in the pipeline?

    abstract:PURPOSE OF REVIEW:To provide an overview of currently available immunosuppressive strategies and novel therapeutic developments in pancreas transplantation. RECENT FINDINGS:From 1966 through 2012 more than 30 000 pancreas transplantations have been performed around the world with excellent patient and graft survival. ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e32835c6eda

    authors: Kimelman M,Brandacher G

    更新日期:2013-02-01 00:00:00

  • Antibody-mediated rejection.

    abstract:PURPOSE OF REVIEW:Pulmonary antibody-mediated rejection (AMR) while contributing to acute and chronic allograft dysfunction remains a diagnostic and therapeutic challenge. The diagnostic tenets upon which AMR is defined will be reviewed in the light of recent studies. RECENT FINDINGS:The introduction of solid phase as...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000235

    authors: Westall GP,Paraskeva MA,Snell GI

    更新日期:2015-10-01 00:00:00

  • Obesity management in the liver transplant recipient: the role of bariatric surgery.

    abstract:PURPOSE OF REVIEW:The epidemic of obesity is having a marked impact on liver transplant candidates and recipients, and optimal approach for the obese liver transplant patient is not yet defined. The current review summarizes the role of bariatric surgery in obese liver transplant patients. RECENT FINDINGS:NASH is now ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000513

    authors: Bonner K,Heimbach JK

    更新日期:2018-04-01 00:00:00

  • The global role of kidney transplantation.

    abstract::World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and better, but ...

    journal_title:Current opinion in organ transplantation

    pub_type: 社论

    doi:10.1097/MOT.0b013e328354c277

    authors: Garcia GG,Harden P,Chapman J,World Kidney Day Steering Committee 2012.

    更新日期:2012-08-01 00:00:00

  • Antibody-mediated rejection of the cardiac allograft: where do we stand in 2012?

    abstract:PURPOSE OF REVIEW:The review will discuss the current pathological criteria for the diagnosis and classification of antibody-mediated rejection (AMR) in the cardiac allograft. RECENT FINDINGS:Until recently, the diagnosis of AMR required clinical dysfunction, presence of donor specific antibodies and pathological alte...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e328353660f

    authors: Berry GJ

    更新日期:2012-06-01 00:00:00

  • Mechanical circulatory support challenges in pediatric and (adult) congenital heart disease.

    abstract:PURPOSE OF REVIEW:Increased miniaturization of ventricular assist devices (VADs) and new mechanical support strategies (MCS) has increased the use of MCS in the pediatric and congenital heart disease (CHD) population. This comes with the need for care providers specialized in this field to determine optimal patient and...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000522

    authors: Schweiger M,Lorts A,Conway J

    更新日期:2018-06-01 00:00:00

  • Antibody-mediated rejection after intestinal transplantation.

    abstract:PURPOSE OF REVIEW:In spite of impressive improvements in short-term outcomes for intestine transplant recipients, late allograft loss continues to plague the field. Attention has mostly been focused on T-cell-mediated cellular mechanisms of allograft rejection to explain these losses; however, as in other forms of soli...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e3283533847

    authors: Dick AA,Horslen S

    更新日期:2012-06-01 00:00:00

  • Pancreas vs. islet transplantation: a call on the future.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review recent reports on whole pancreas and islet cell transplantation. It focuses on 'what the call to the future looks like' for both therapies as treatment options for those type 1 diabetes patients who do not respond well to conventional therapy. RECENT FINDINGS:The ...

    journal_title:Current opinion in organ transplantation

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/MOT.0b013e32833553f8

    authors: Vardanyan M,Parkin E,Gruessner C,Rodriguez Rilo HL

    更新日期:2010-02-01 00:00:00

  • Lung re-transplantation: review.

    abstract:PURPOSE OF REVIEW:Re-transplantation of the lung has come of age. Here, we wish to review the recent literature on the topic and discuss clinical implications. RECENT FINDINGS:Many large volume transplant centres routinely perform lung re-transplantation with satisfactory outcomes. The main indication is bronchiolitis...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e328357d8ba

    authors: Warnecke G,Haverich A

    更新日期:2012-10-01 00:00:00

  • Live donor adult liver transplantation.

    abstract:PURPOSE OF REVIEW:Because the gap between liver organ supply and demand continues to increase, adult living-donor liver transplantation continues to represent a significant pool of organs. RECENT FINDINGS:With this in mind, we discuss recent issues in adult living-donor liver transplantation, including issues with don...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e328300a352

    authors: Yeh H,Olthoff KM

    更新日期:2008-06-01 00:00:00

  • Lung bioengineering: advances and challenges in lung decellularization and recellularization.

    abstract:PURPOSE OF REVIEW:Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000584

    authors: Uriarte JJ,Uhl FE,Rolandsson Enes SE,Pouliot RA,Weiss DJ

    更新日期:2018-12-01 00:00:00

  • Ethical considerations in live donor transplantation: should complications be tolerated?

    abstract:PURPOSE OF REVIEW:Although living donor transplantation is considered an ethically acceptable undertaking for the purpose of saving another's life, its safety remains under investigation. RECENT FINDINGS:Although living donors undertake considerable medical risks for no direct medical benefit, the question remains whe...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e32835f3f2c

    authors: Gordon EJ

    更新日期:2013-04-01 00:00:00

  • Stimulatory and inhibitory receptor interactions in xenotransplantation.

    abstract:PURPOSE OF REVIEW:Cellular human antipig immune responses are increasingly recognized as an important barrier to successful clinical xenotransplantation. This review addresses the role of monocytes/macrophages, natural killer (NK) cells, and T cells in xenograft rejection. We focus on the receptor-ligand interactions t...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e328336b8e5

    authors: Plege A,Schwinzer R

    更新日期:2010-04-01 00:00:00

  • Towards xenotransplantation of pig islets in the clinic.

    abstract:PURPOSE OF REVIEW:Porcine islet xenotransplantation into humans faces two major hurdles - safety issues related to xenosis and xenorejection of the transplants. The former has been overcome mainly by selection of a suitable disease-free source herd. RECENT FINDINGS:Four strategies have been employed to date to overcom...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e3283449dec

    authors: Elliott RB,Living Cell Technologies.

    更新日期:2011-04-01 00:00:00

  • Microchimerism: tolerance vs. sensitization.

    abstract:PURPOSE OF REVIEW:The bidirectional exchange of cells, both mature and progenitor types, at the maternal-fetal interface is a common feature of mammalian reproduction. The presence of semiallogeneic cells in a host can have significant immunological effects on transplantation tolerance and rejection. Here, we review re...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e3283484b57

    authors: Dutta P,Burlingham WJ

    更新日期:2011-08-01 00:00:00

  • Tolerance induction via mixed chimerism in vascularized composite allotransplantation: is it time for clinical application?

    abstract:PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000248

    authors: Cetrulo CL Jr,Drijkoningen T,Sachs DH

    更新日期:2015-12-01 00:00:00

  • Life after pancreas transplantation: reversal of diabetic lesions.

    abstract:PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000045

    authors: Dunn TB

    更新日期:2014-02-01 00:00:00

  • Self-antigens and rejection: a proteomic analysis.

    abstract:PURPOSE OF REVIEW:Allo- and autoantibodies have been found to play important roles in both acute and chronic allograft rejection in organ transplantation, although only recently have non-human leukocyte antigen (non-HLA), nondonor-specific antibodies been given a more in-depth treatment. This review summarizes recent r...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000328

    authors: Yang JY,Sigdel TK,Sarwal MM

    更新日期:2016-08-01 00:00:00

  • Liver xenotransplantation.

    abstract:PURPOSE OF REVIEW:There continues to be an inadequate organ supply and lack of effective temporary support, for patients with liver failure. The purpose of this review is to discuss recent progress in the field of orthotopic pig-to-nonhuman primate (NHP) liver xenotransplantation (LXT). RECENT FINDINGS:From 1968 to 20...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000459

    authors: Patel MS,Louras N,Vagefi PA

    更新日期:2017-12-01 00:00:00

  • Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment.

    abstract:PURPOSE OF REVIEW:Transplantation of islets of Langerhans is an emerging treatment procedure for patients with severe type 1 diabetes, but despite recent progress the procedure is associated with massive tissue loss caused by an inflammatory reaction termed instant blood-mediated inflammatory reaction (IBMIR). This rea...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e32834c2393

    authors: Nilsson B,Ekdahl KN,Korsgren O

    更新日期:2011-12-01 00:00:00

  • Intestinal transplantation: current outcomes and opportunities.

    abstract:PURPOSE OF REVIEW:This review highlights current outcomes in intestinal transplantation and summarizes advances that have recently occurred in five interrelated areas: progress in intestinal rehabilitation, immunologic and technical modifications, awareness of opportunities for improved allograft monitoring, and better...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e328330680d

    authors: Mazariegos GV

    更新日期:2009-10-01 00:00:00

  • The role of complement in regulating the alloresponse.

    abstract:PURPOSE OF REVIEW:This review emphasizes new information concerning the role of anaphylatoxins in the regulation of the immune response to allografts. Its timeliness relates the growing concept of the innate immune response as a regulator of the adaptive immune system and to how this concept lends itself to therapeutic...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e32831ec551

    authors: Sacks S,Lee Q,Wong W,Zhou W

    更新日期:2009-02-01 00:00:00

  • Cardiac and pulmonary donor procurement.

    abstract:PURPOSE OF REVIEW:Within the United States, donor heart and lung procurement varies between institutions and among surgeons within the same institution sometimes. The purpose of this article is to review the history of donor heart and lung procurement, the surgical techniques, and pitfalls. RECENT FINDINGS:The current...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000530

    authors: Copeland H,Copeland J,Hayanga JWA

    更新日期:2018-06-01 00:00:00

  • In-vivo normothermic recirculation: an update.

    abstract:PURPOSE OF REVIEW:The use of nonheart-beating donors (NHBD), as a source for liver grafts, is the only way to objectively increase the activity in liver transplantation. Through the use of more strict criteria, 1-year graft survival has increased from 50% in initial series to 84-100%. With respect to type II NHBD (fail...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e3283373488

    authors: García-Valdecasas JC,Fondevila C

    更新日期:2010-04-01 00:00:00

  • Evolving aspects of liver transplantation for nonalcoholic steatohepatitis.

    abstract:PURPOSE OF REVIEW:Nonalcoholic steatohepatitis (NASH), obesity, and the metabolic syndrome are highly prevalent. NASH, a rare indication for liver transplantation in the early 1990s, is now the third most common indication. This review considers key aspects of the liver transplantation for NASH. RECENT FINDINGS:NASH i...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e3283615d30

    authors: Charlton M

    更新日期:2013-06-01 00:00:00

  • Current status of pediatric intestinal transplant in Europe.

    abstract:PURPOSE OF REVIEW:This review features articles published during 2018 and 2019 regarding pediatric visceral transplantation in Europe. In this biannual review, the authors identify and summarize key articles pertinent to clinical and research areas. RECENT FINDINGS:There is a trend to a lower use of intestinal transpl...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000736

    authors: Andres AM,Ramos E,Hernandez F

    更新日期:2020-04-01 00:00:00

  • Heart transplantation in cardiac storage diseases: data on Fabry disease and cardiac amyloidosis.

    abstract:PURPOSE OF REVIEW:To deeply investigate one type of intracellular cardiac storage disease, the Fabry disease and one example of extracellular cardiac storage disease, the cardiac amyloidosis, with the aim to collect data about cardiac treatment at the end-stage level and the feasibility of heart transplantation (HTx) i...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000756

    authors: Di Nora C,Livi U

    更新日期:2020-06-01 00:00:00

  • ABO-incompatible kidney transplantation: current practice and the decade ahead.

    abstract:PURPOSE OF REVIEW:With rapidly growing deceased donor kidney transplant waiting lists, solutions to the shortage of kidney donors need to come from many corners. This review focuses on the current results and upcoming medications that will allow broad expansion of ABO-incompatible transplantation as one facet to combat...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0b013e32833bfbba

    authors: Crew RJ,Ratner LE

    更新日期:2010-08-01 00:00:00

  • Orchestration of transplantation tolerance by regulatory dendritic cell therapy or in-situ targeting of dendritic cells.

    abstract:PURPOSE OF REVIEW:Extensive research in murine transplant models over the past two decades has convincingly demonstrated the ability of regulatory dendritic cells (DCregs) to promote long-term allograft survival. We review important considerations regarding the source of therapeutic DCregs (donor or recipient) and thei...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审

    doi:10.1097/MOT.0000000000000097

    authors: Morelli AE,Thomson AW

    更新日期:2014-08-01 00:00:00

  • Considerations and experience driving expansion of combined heart-liver transplantation.

    abstract:PURPOSE OF REVIEW:Heart transplantation concomitant with a liver transplant may be warranted when end-stage heart failure results in irreversible liver failure. Previously reported outcomes have been excellent yet the specific immunoprotective role of the liver allograft is not known. We review the current literature a...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章

    doi:10.1097/MOT.0000000000000804

    authors: Gong T,Hall S

    更新日期:2020-10-01 00:00:00