Liver transplantation and risk of bleeding.

abstract：PURPOSE OF REVIEW:To describe the latest investigations into the role of frailty and assessment of other aging-related issues in the solid organ transplant candidate and recipient. This information is relevant for all involved in the care of transplant patients, but is especially relevant in infectious diseases, given ...

journal_title：Current opinion in organ transplantation

authors： Schaenman J,Goldwater D,Malinis M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Discuss the recent progress on the clinical use of mesenchymal stromal (stem) cells (MSC) in solid organ transplantation (SOT). RECENT FINDINGS:Tissue repair and immunomodulatory properties have been recognized for MSC obtained from different human tissues. MSC-based therapy has been proposed to redu...

journal_title：Current opinion in organ transplantation

authors： Pileggi A,Xu X,Tan J,Ricordi C

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation provides the only proven method to restore long-term normoglycemia in patients with insulin-dependent diabetes mellitus. Although many studies describe the most important risk factors for short-term survival of a pancreas transplant, more information about factors that disting...

journal_title：Current opinion in organ transplantation

authors： Gruessner AC,Gruessner RW

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Organ shortage in transplantation medicine forces surgical research toward the development of more efficient approaches in organ preservation to enable the application of 'less than optimal' grafts. This review summarizes current techniques aiming to recondition cold-stored organ grafts prior to trans...

journal_title：Current opinion in organ transplantation

authors： Minor T,von Horn C,Paul A

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organizat...

journal_title：Current opinion in organ transplantation

authors： Little MH,Takasato M

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In June 2011 the US Food and Drug Administration approved belatacept (Nulojix; Bristol-Myers Squibb, Princeton, New Jersey, USA) for the prophylaxis of organ rejection in adult kidney transplant recipients. This review will discuss the use of belatacept for the prevention of acute rejection as part of...

journal_title：Current opinion in organ transplantation

authors： Wojciechowski D,Vincenti F

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Lung transplantation survival is still limited compared with other solid organ transplant modalities, due to a range of factors that are continuing to be elucidated. However, new research is emerging which indicates that the microbiome of the lungs, and of other organs, may have important implications...

journal_title：Current opinion in organ transplantation

authors： Mitchell AB

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

journal_title：Current opinion in organ transplantation

authors： Dunn TB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute kidney failure in the perioperative liver transplant recipients results in an increased hospital length of stay, acute rejection, infection rate and overall mortality. Thus, it is of great importance to be able to recognize, prevent and treat kidney injury. RECENT FINDINGS:Immediate post liver ...

journal_title：Current opinion in organ transplantation

authors： Biancofiore G,Davis CL

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart transplantation is the only curative treatment option for end-stage heart failure. However, a shortage of donor organs is a major limitation of this approach. Regenerative medicine targets the goal of increasing the number of available hearts for transplantation. In this review, we highlight the...

journal_title：Current opinion in organ transplantation

authors： Taylor DA,Elgalad A,Sampaio LC

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the complex interplay between the microbiota and host immune responses, and its impact on intestinal transplantation and allograft rejection. RECENT FINDINGS:Recent findings highlight the importance of Paneth cells as crucial producers of antimicrobial peptides that control th...

journal_title：Current opinion in organ transplantation

authors： Kroemer A,Elsabbagh AM,Matsumoto CS,Zasloff M,Fishbein TM

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced ...

journal_title：Current opinion in organ transplantation

authors： Uriarte JJ,Uhl FE,Rolandsson Enes SE,Pouliot RA,Weiss DJ

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Several expanded criteria for liver transplantation for hepatocellular carcinoma (HCC) have been suggested out of concern that the Milan criteria may be too strict, and thereby exclude patients who could benefit from this surgical procedure. However, most expanded criteria were designed for deceased d...

journal_title：Current opinion in organ transplantation

authors： Lee HW,Suh KS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Dysregulated coagulation is now recognized as a major contributor to graft loss in xenotransplantation. This review summarizes recent data on putative mechanisms of pathogenic coagulation in xenotransplantation and discusses progress on strategies to overcome them. RECENT FINDINGS:Evidence continues ...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,d'Apice AJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent reports on whole pancreas and islet cell transplantation. It focuses on 'what the call to the future looks like' for both therapies as treatment options for those type 1 diabetes patients who do not respond well to conventional therapy. RECENT FINDINGS:The ...

journal_title：Current opinion in organ transplantation

authors： Vardanyan M,Parkin E,Gruessner C,Rodriguez Rilo HL

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The Notch signaling pathway is known to play a pivotal role in T- and B-cell development and fate, presenting it as an attractive therapeutic target in alloimmunity. This review provides an overview of the mechanisms of Notch signaling, focusing on new insights into its diverse functions in T-cell act...

journal_title：Current opinion in organ transplantation

authors： Magee CN,Riella LV

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 and type 2 diabetes mellitus represent a widespread metabolic disorder, related to autoimmune β-cell destruction and insulin resistance, leading to β-cell dysfunction, respectively, that are associated with severe chronic complications with irreversible multiorgan morphological and functional d...

journal_title：Current opinion in organ transplantation

authors： Calafiore R,Montanucci P,Basta G

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In this article, we will review the outcomes of patients with intestinal transplant (ITx) with a focus on factors affecting long-term graft and patient survival. RECENT FINDINGS:The most recent International Intestinal Transplant Registry reports a 1-, 5-, and 10-year graft survival of 71%, 50%, and ...

journal_title：Current opinion in organ transplantation

authors： Amin A,Farmer DG

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascularized composite allograft (VCA) transplantation restores function and form following major soft tissue and musculoskeletal injury. Lifelong immunosuppression is necessary for graft function and survival but acute skin-targeted rejection episodes remain common. We review recent advances in skin ...

journal_title：Current opinion in organ transplantation

authors： Chadha R,Leonard DA,Kurtz JM,Cetrulo CL Jr

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Donor-derived disease with Mycobacterium tuberculosis (MTB) is likely to become more common as donor pools expand due to increasing transplant volume coupled with patterns of migration and global mobility. Our article reviews the current literature and provides a rational approach for clinicians manag...

journal_title：Current opinion in organ transplantation

authors： Gibb J,Wong D

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressiv...

journal_title：Current opinion in organ transplantation

authors： Nunes-Cabaço H,Sousa AE

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:With improving survival rates following solid organ transplantation, assessment of its success has broadened with a focus on long-term outcomes, including nongraft-related medical outcomes and family and patient perceptions of quality of life. Posttransplant renal dysfunction contributes to long-term ...

journal_title：Current opinion in organ transplantation

authors： Campbell KM,Bucuvalas JC

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation. RECENT FINDINGS:During an alloresponse, Toll-like receptors can be engaged by both damage-induced endogenous ligands or mi...

journal_title：Current opinion in organ transplantation

authors： Alegre ML,Goldstein DR,Chong AS

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the current state of the epidemiology, diagnosis, and management of human herpesvirus 6 (HHV-6) infection after solid organ transplantation. RECENT FINDINGS:HHV-6 reactivates commonly during the early weeks after solid organ transplantation. However, disease due to HHV-6 is un...

journal_title：Current opinion in organ transplantation

authors： Razonable RR

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade intestine transplantation has been accepted as standard therapy for patients with life-threatening complications of parenteral nutrition. For patients without life-threatening complications, continued therapy with parenteral nutrition has been standard despite seemingly similar pa...

journal_title：Current opinion in organ transplantation

authors： Sudan D

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:With rapidly growing deceased donor kidney transplant waiting lists, solutions to the shortage of kidney donors need to come from many corners. This review focuses on the current results and upcoming medications that will allow broad expansion of ABO-incompatible transplantation as one facet to combat...

journal_title：Current opinion in organ transplantation

authors： Crew RJ,Ratner LE

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Manipulating costimulatory signals has been shown to alter T cell responses and prolong graft survival in solid organ transplantation. Our understanding of and ability to target various costimulation pathways continues to evolve. RECENT FINDINGS:Since the approval of belatacept in kidney transplantat...

journal_title：Current opinion in organ transplantation

authors： Schroder PM,Fitch ZW,Schmitz R,Choi AY,Kwun J,Knechtle SJ

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss the current state of donation after circulatory death (DCD). We define the DCD donor and describe the current protocols in management of the DCD patient. We then discuss current techniques in organ procurement of the lung and abdominal organs. RECENT FINDINGS:Although donat...

journal_title：Current opinion in organ transplantation

authors： Algahim MF,Love RB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Morbidity and mortality after liver transplantation continue to be significantly influenced by infectious complications. A particular concern is transmission of pathogens through the graft, which may cause significant disease in the recipient. RECENT FINDINGS:For frequently transmitted herpes viruses...

journal_title：Current opinion in organ transplantation

authors： Bonatti H,Sawyer R,Dickson RC,Razonable R,Schmitt T,Mendez J,Singh N,Pruett T

更新日期：2007-06-01 00:00:00