ABO-incompatible kidney transplantation: current practice and the decade ahead.

abstract：PURPOSE OF REVIEW:To review the experience to date and unique challenges associated with liver transplantation in hepatitis C virus (HCV)/HIV-coinfected patients. RECENT FINDINGS:The prevalence of cirrhosis and hepatocellular carcinoma is rising among HIV-infected individuals. With careful patient selection and in the...

journal_title：Current opinion in organ transplantation

authors： Kardashian AA,Price JC

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Accurate measurement of human leukocyte antigen antibodies is critical for making clinical decisions treating patients awaiting transplantation or monitoring them post transplantation. Single antigen bead assay results are given as Mean Fluorescence Intensity, falling short of providing the required q...

journal_title：Current opinion in organ transplantation

authors： Maguire CH,Schinstock CA,Tambur AR

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascularized composite allograft (VCA) transplantation restores function and form following major soft tissue and musculoskeletal injury. Lifelong immunosuppression is necessary for graft function and survival but acute skin-targeted rejection episodes remain common. We review recent advances in skin ...

journal_title：Current opinion in organ transplantation

authors： Chadha R,Leonard DA,Kurtz JM,Cetrulo CL Jr

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Dysregulated coagulation is now recognized as a major contributor to graft loss in xenotransplantation. This review summarizes recent data on putative mechanisms of pathogenic coagulation in xenotransplantation and discusses progress on strategies to overcome them. RECENT FINDINGS:Evidence continues ...

journal_title：Current opinion in organ transplantation

authors： Cowan PJ,d'Apice AJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressiv...

journal_title：Current opinion in organ transplantation

authors： Nunes-Cabaço H,Sousa AE

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunological tolerance has long been considered the 'holy grail' of organ transplantation. Although tolerance has been an active area of research for 70 years, its clinical application has only been possible in the last two decades and widespread use remains an, as yet, unattained goal. Recent advanc...

journal_title：Current opinion in organ transplantation

authors： Rickert CG,Markmann JF

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To outline recent studies describing the mechanisms of antibody-mediated rejection (AMR) and new clinical protocols aimed at prevention and/or treatment of this difficult clinical entity. RECENT FINDINGS:The natural history of acute AMR after positive cross-match kidney transplantation involves an ac...

journal_title：Current opinion in organ transplantation

authors： Stegall MD,Gloor JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of dia...

journal_title：Current opinion in organ transplantation

authors： Dunn TB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the latest investigations into the role of frailty and assessment of other aging-related issues in the solid organ transplant candidate and recipient. This information is relevant for all involved in the care of transplant patients, but is especially relevant in infectious diseases, given ...

journal_title：Current opinion in organ transplantation

authors： Schaenman J,Goldwater D,Malinis M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart transplantation concomitant with a liver transplant may be warranted when end-stage heart failure results in irreversible liver failure. Previously reported outcomes have been excellent yet the specific immunoprotective role of the liver allograft is not known. We review the current literature a...

journal_title：Current opinion in organ transplantation

authors： Gong T,Hall S

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Exposure to noninherited maternal antigens (NIMAs) in fetal and neonatal life has life-long immunological consequences. Although there is a plethora of evidence of effects of mother on the immune responses of her offspring, there is very little knowledge available on how exposure to NIMA can result in...

journal_title：Current opinion in organ transplantation

authors： Dutta P,Burlingham WJ

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequate insulin-producing pancreatic β-cell mass is a key feature of both type 1 and type 2 diabetes. Efforts to regenerate β-cell mass from pancreatic precursors may thus ameliorate absolute or relative insulin deficiency, thereby improving glucose homeostasis. A clear understanding of the process...

journal_title：Current opinion in organ transplantation

authors： Crutchlow MF,Stoffers DA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Burgeoning literature on antibody-mediated rejection (ABMR) has led to a perception that T-cell-mediated rejection (TCMR) is no longer a significant problem. This premise needs to be carefully appraised. RECENT FINDINGS:A review of the literature indicates that TCMR remains an independent-risk factor...

journal_title：Current opinion in organ transplantation

authors： Randhawa P

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss the current state of donation after circulatory death (DCD). We define the DCD donor and describe the current protocols in management of the DCD patient. We then discuss current techniques in organ procurement of the lung and abdominal organs. RECENT FINDINGS:Although donat...

journal_title：Current opinion in organ transplantation

authors： Algahim MF,Love RB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This article summarizes the complex interplay between the microbiota and host immune responses, and its impact on intestinal transplantation and allograft rejection. RECENT FINDINGS:Recent findings highlight the importance of Paneth cells as crucial producers of antimicrobial peptides that control th...

journal_title：Current opinion in organ transplantation

authors： Kroemer A,Elsabbagh AM,Matsumoto CS,Zasloff M,Fishbein TM

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of sensitized heart transplant candidates is rising. Highly sensitized patients are disadvantaged because they encounter longer waiting times to heart transplant. Strategies to reduce their waiting times include waitlist prioritization and desensitization therapies. The purpose of this revi...

journal_title：Current opinion in organ transplantation

authors： Aleksova N,Ross HJ

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade intestine transplantation has been accepted as standard therapy for patients with life-threatening complications of parenteral nutrition. For patients without life-threatening complications, continued therapy with parenteral nutrition has been standard despite seemingly similar pa...

journal_title：Current opinion in organ transplantation

authors： Sudan D

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune monitoring is needed in small bowel transplantation (SBTx) because of a high incidence of rejection and graft loss, and life-threatening complications of high-dose prophylactic immunosuppression. RECENT FINDINGS:Clinical tests relevant to SBTx include methods to detect antidonor human leukocyt...

journal_title：Current opinion in organ transplantation

authors： Sindhi R,AshokKumar C,Mazariegos G,Nayyar N,Ningappa M,Soltys K,Bond G,Sun Q,Humar A,Abu-Elmagd K,Zeevi A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence in literature regarding incidence and risk factors for biliary complications in living donor liver transplantation (LDLT), and current concepts in evaluation of donor biliary anatomy and surgical techniques of biliary reconstruction, to reduce the incidence of biliary comp...

journal_title：Current opinion in organ transplantation

authors： Bhangui P,Saha S

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Because the gap between liver organ supply and demand continues to increase, adult living-donor liver transplantation continues to represent a significant pool of organs. RECENT FINDINGS:With this in mind, we discuss recent issues in adult living-donor liver transplantation, including issues with don...

journal_title：Current opinion in organ transplantation

authors： Yeh H,Olthoff KM

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

journal_title：Current opinion in organ transplantation

authors： Cetrulo CL Jr,Drijkoningen T,Sachs DH

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary graft failure, which represents one of the most frequent causes of early mortality, is mostly caused by ischemia-reperfusion injury (IRI). IRI may also induce rejection, which is the principal cause of mortality after transplantation. It is essential to understand the mechanism of pulmonary IR...

journal_title：Current opinion in organ transplantation

authors： Chen F,Date H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Transplantation of islets of Langerhans is an emerging treatment procedure for patients with severe type 1 diabetes, but despite recent progress the procedure is associated with massive tissue loss caused by an inflammatory reaction termed instant blood-mediated inflammatory reaction (IBMIR). This rea...

journal_title：Current opinion in organ transplantation

authors： Nilsson B,Ekdahl KN,Korsgren O

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:New immunosuppressive agents have decreased the incidence of acute rejection rates without improvement in long-term outcomes. Drug toxicity due to a narrow therapeutic index and individual variations in pharmacokinetics and pharmacodynamics significantly contributes to the inferior outcomes. This revi...

journal_title：Current opinion in organ transplantation

authors： Wavamunno MD,Chapman JR

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:A significant shift in our understanding of the molecular and cellular basis for inflammatory bowel disease (IBD) mirrors research that has been ongoing in intestinal transplantation. The blurring of lines between these two disease states creates an avenue into potential therapeutic interventions whic...

journal_title：Current opinion in organ transplantation

authors： Belyayev L,Loh K,Fishbein TM,Kroemer A

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Morbidity and mortality after liver transplantation continue to be significantly influenced by infectious complications. A particular concern is transmission of pathogens through the graft, which may cause significant disease in the recipient. RECENT FINDINGS:For frequently transmitted herpes viruses...

journal_title：Current opinion in organ transplantation

authors： Bonatti H,Sawyer R,Dickson RC,Razonable R,Schmitt T,Mendez J,Singh N,Pruett T

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Lungs are extremely susceptible to injury, and despite advances in surgical management and immunosuppression, outcomes for lung transplantation are the worst of any solid organ transplant. The success of lung transplantation is limited by high rates of primary graft dysfunction because of ischemia-rep...

journal_title：Current opinion in organ transplantation

authors： Laubach VE,Sharma AK

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The first generation of implantable pulsatile ventricular assist devices (VADs) has proven to be successful as bridge to transplantation. Adverse events such as mechanical failure and infections, however, limit their use for long-term support (>1 year) or as alternative for heart transplantation. Newe...

journal_title：Current opinion in organ transplantation

authors： Lahpor JR

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Orthotopic liver transplant (OLT) is a major surgical procedure that can be both challenging and lengthy. One of the common findings in end-stage liver disease is renal failure, whether acute or chronic, which may complicate the intraoperative course. RECENT FINDINGS:The use of intraoperative hemodia...

journal_title：Current opinion in organ transplantation

authors： Sedra AH,Strum E

更新日期：2011-06-01 00:00:00