Histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation.

abstract：:Physiological cell deaths occur ubiquitously throughout biology and have common attributes, including apoptotic morphology with mitosis-like chromatin condensation and prelytic genome digestion. The fundamental question is whether a common mechanism of dying underlies these common hallmarks of death. Here we describe ...

journal_title：Molecular and cellular biology

authors： Harvey KJ,Blomquist JF,Ucker DS

更新日期：1998-05-01 00:00:00

abstract：:In Drosophila and several other metazoan organisms, there are two genes that encode related but distinct homologs of ADA2-type transcriptional adaptors. Here we describe mutations of the two Ada2 genes of Drosophila melanogaster. By using mutant Drosophila lines, which allow the functional study of individual ADA2s, w...

journal_title：Molecular and cellular biology

authors： Pankotai T,Komonyi O,Bodai L,Ujfaludi Z,Muratoglu S,Ciurciu A,Tora L,Szabad J,Boros I

更新日期：2005-09-01 00:00:00

abstract：:The human immunodeficiency virus type 1 Rev protein contains a nuclear export signal (NES) that is required for Rev-mediated RNA export in mammals as well as in the yeast Saccharomyces cerevisiae. The Rev NES has been shown to specifically interact with a human (hRIP/RAB1) and a yeast (yRip1p) protein in the two-hybri...

journal_title：Molecular and cellular biology

authors： Stutz F,Izaurralde E,Mattaj IW,Rosbash M

更新日期：1996-12-01 00:00:00

abstract：:The expression of the Drosophila segmentation gene fushi tarazu (ftz) is controlled at the level of transcription. The proximal enhancer, located approximately 3.4 kb upstream of the transcription start site, directs lacZ fusion gene expression in a ftz-like seven-stripe pattern in transgenic fly embryos. We have take...

journal_title：Molecular and cellular biology

authors： Han W,Yu Y,Altan N,Pick L

更新日期：1993-09-01 00:00:00

abstract：:cyt-PTP epsilon is a naturally occurring nonreceptor form of the receptor-type protein tyrosine phosphatase (PTP) epsilon. As such, cyt-PTP epsilon enables analysis of phosphatase regulation in the absence of extracellular domains, which participate in dimerization and inactivation of the receptor-type phosphatases re...

journal_title：Molecular and cellular biology

authors： Toledano-Katchalski H,Tiran Z,Sines T,Shani G,Granot-Attas S,den Hertog J,Elson A

更新日期：2003-08-01 00:00:00

abstract：:The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) can be phosphorylated at serine 2 (Ser-2) and serine 5 (Ser-5) of the CTD heptad repeat YSPTSPS, and this phosphorylation is important in coupling transcription to RNA processing, including 5' capping, splicing, and polyadenylation. The mammalian endogen...

journal_title：Molecular and cellular biology

authors： Cheng C,Sharp PA

更新日期：2003-03-01 00:00:00

abstract：:Endonuclease G (endo G) is one of the most abundant nucleases in eukaryotic cells. It is encoded in the nucleus and imported to the mitochondrial intermembrane space. This nuclease is active on single- and double-stranded DNA. We genetically disrupted the endo G gene in mice without disturbing a conserved, overlapping...

journal_title：Molecular and cellular biology

authors： Irvine RA,Adachi N,Shibata DK,Cassell GD,Yu K,Karanjawala ZE,Hsieh CL,Lieber MR

更新日期：2005-01-01 00:00:00

abstract：:The proto-oncogene pp60(c-Src) (c-Src) is activated in many types of cancer and contributes to the transformed phenotype of the tumor, although its role is not yet fully understood. Here we report that active Src elevates the levels of beta-catenin by enhancing cap-dependent translation. Src induces phosphorylation of...

journal_title：Molecular and cellular biology

authors： Karni R,Gus Y,Dor Y,Meyuhas O,Levitzki A

更新日期：2005-06-01 00:00:00

abstract：:Numb proteins are evolutionarily conserved signaling molecules that make the daughter cells different after asymmetric divisions by segregating to only one daughter. They contain distinct binding motifs for alpha-adaptin (alpha-Ada) and proteins with Eps15 homology (EH) domains, which regulate endocytosis, and for E3 ...

journal_title：Molecular and cellular biology

authors： Tang H,Rompani SB,Atkins JB,Zhou Y,Osterwalder T,Zhong W

更新日期：2005-04-01 00:00:00

abstract：:The ubiquitin-proteasome pathway (UPP) is involved in regulation of multiple cellular processes. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is a prototypic target of the UPP and, as such, is stabilized under conditions of proteasomal inhibition. Using carbonic anhydrase IX (CAIX) and vascular endothelial growth fa...

journal_title：Molecular and cellular biology

authors： Kaluz S,Kaluzová M,Stanbridge EJ

更新日期：2006-08-01 00:00:00

abstract：:The Eph receptors are the largest known family of receptor tyrosine kinases and are notable for distinctive expression patterns in the nervous system and in early vertebrate development. However, all were identified as orphan receptors, and only recently have there been descriptions of a corresponding family of ligand...

journal_title：Molecular and cellular biology

authors： Bergemann AD,Cheng HJ,Brambilla R,Klein R,Flanagan JG

更新日期：1995-09-01 00:00:00

abstract：:To understand the mechanism of retinoid resistance, we studied the subcellular localization and function of retinoid receptors in human breast cancer cell lines. Retinoid X receptor alpha (RXR alpha) localized throughout the nucleoplasm in retinoid-sensitive normal human mammary epithelial cells and in retinoid-respon...

journal_title：Molecular and cellular biology

authors： Tanaka T,Dancheck BL,Trifiletti LC,Birnkrant RE,Taylor BJ,Garfield SH,Thorgeirsson U,De Luca LM

更新日期：2004-05-01 00:00:00

abstract：:Ure2p of Saccharomyces cerevisiae normally functions in blocking utilization of a poor nitrogen source when a good nitrogen source is available. The non-Mendelian genetic element [URE3] is a prion (infectious protein) form of Ure2p, so that overexpression of Ure2p induces the de novo appearance of infectious [URE3]. E...

journal_title：Molecular and cellular biology

authors： Maddelein ML,Wickner RB

更新日期：1999-06-01 00:00:00

abstract：:The 3' poly(A) tail of eukaryotic mRNAs and the poly(A) binding protein (PABP) play important roles in the regulation of translation. Recently, a human PABP-interacting protein, Paip2, which disrupts the PABP-poly(A) interaction and consequently inhibits translation, was described. To gain insight into the biological ...

journal_title：Molecular and cellular biology

authors： Roy G,Miron M,Khaleghpour K,Lasko P,Sonenberg N

更新日期：2004-02-01 00:00:00

abstract：:The ability of basic helix-loop-helix muscle regulatory factors (MRFs), such as MyoD, to convert nonmuscle cells to a myogenic lineage is regulated by numerous growth factor and oncoprotein signaling pathways. Previous studies have shown that H-Ras 12V inhibits differentiation to a skeletal muscle lineage by disruptin...

journal_title：Molecular and cellular biology

authors： Ramocki MB,Johnson SE,White MA,Ashendel CL,Konieczny SF,Taparowsky EJ

更新日期：1997-07-01 00:00:00

abstract：:Human insulin-like growth factor II (IGF-II) mRNAs are subject to site-specific endonucleolytic cleavage in the 3' untranslated region, leading to an unstable 5' cleavage product containing the IGF-II coding region and a very stable 3' cleavage product of 1.8 kb. This endonucleolytic cleavage is most probably the firs...

journal_title：Molecular and cellular biology

authors： Scheper W,Meinsma D,Holthuizen PE,Sussenbach JS

更新日期：1995-01-01 00:00:00

abstract：:Initiation of T-lymphocyte-mediated immune responses involves two cellular processes: entry into the cell cycle (G(0)-->G(1)) for clonal proliferation and coordinated changes in surface and secreted molecules that mediate effector functions. However, a point during G(0)-->G(1) beyond which T cells are committed to ent...

journal_title：Molecular and cellular biology

authors： Lea NC,Orr SJ,Stoeber K,Williams GH,Lam EW,Ibrahim MA,Mufti GJ,Thomas NS

更新日期：2003-04-01 00:00:00

abstract：:Homeodomain proteins are transcriptional regulatory factors that, in general, bind DNA with relatively low sequence specificity and affinity. One mechanism homeodomain proteins use to increase their biological specificity is through interactions with other DNA-binding proteins. We have examined how the yeast (Saccharo...

journal_title：Molecular and cellular biology

authors： Mead J,Zhong H,Acton TB,Vershon AK

更新日期：1996-05-01 00:00:00

abstract：:Exposure of mammalian cells to UV irradiation leads to activation of the c-Jun NH(2)-terminal protein kinase (JNK) pathway, which is associated with cell apoptosis. However, the molecular mechanism for JNK activation by UV exposure is not fully understood. We show here an essential role of a multisubstrate adapter, Ga...

journal_title：Molecular and cellular biology

authors： Sun Y,Yuan J,Liu H,Shi Z,Baker K,Vuori K,Wu J,Feng GS

更新日期：2004-02-01 00:00:00

abstract：:A major goal of cancer research is the identification of tumor-specific vulnerabilities that can be exploited for the development of therapies that are selectively toxic to the tumor. We show here that the transcriptional coactivators peroxisome proliferator-activated receptor gamma coactivator 1β (PGC1β) and estrogen...

journal_title：Molecular and cellular biology

authors： Fisher KW,Das B,Kim HS,Clymer BK,Gehring D,Smith DR,Costanzo-Garvey DL,Fernandez MR,Brattain MG,Kelly DL,MacMillan J,White MA,Lewis RE

更新日期：2015-11-01 00:00:00

abstract：:The progression of spermatogenesis involves global changes in chromatin structure and conformation. However, our understanding of the regulation of chromatin changes in germ cells remains limited. Here we describe both in vivo RNA interference and genetic mouse knockout studies that identify a critical role for Yin Ya...

journal_title：Molecular and cellular biology

authors： Wu S,Hu YC,Liu H,Shi Y

更新日期：2009-12-01 00:00:00

abstract：:Integration of protein kinases into transcription activation complexes influences the magnitude of gene expression. The nuclear factor of activated T cells (NFAT) group of proteins are critical transcription factors that direct gene expression in immune and nonimmune cells. A balance of phosphotransferase activity is ...

journal_title：Molecular and cellular biology

authors： Yang TT,Xiong Q,Graef IA,Crabtree GR,Chow CW

更新日期：2005-02-01 00:00:00

abstract：:Members of the type II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors, retinoid X receptors [RXRs], vitamin D receptor, and the peroxisome proliferator-activated receptors) bind to their response sequences with or without ligand. In the absence of ligand, these DNA-b...

journal_title：Molecular and cellular biology

authors： Mathur M,Tucker PW,Samuels HH

更新日期：2001-04-01 00:00:00

abstract：:Nat4, also designated NatD, was previously shown to acetylate the N termini of histones H2A and H4, which have SGGKG and SGRGK N termini (O. K. Song, X. Wang, J. H. Waterborg, and R. Sternglanz, J. Biol. Chem. 278:38109-38112, 2003). The analysis of chimeric proteins with various N-terminal segments of histone H4 fuse...

journal_title：Molecular and cellular biology

authors： Polevoda B,Hoskins J,Sherman F

更新日期：2009-06-01 00:00:00

abstract：:Human La protein has been shown to serve as a transcription factor for RNA polymerase III (pol III) by facilitating transcription termination and recycling of transcription complexes. In addition, La binds to the 3' oligo(U) ends common to all nascent pol III transcripts, and in the case of B1-Alu RNA, protects it fro...

journal_title：Molecular and cellular biology

authors： Goodier JL,Fan H,Maraia RJ

更新日期：1997-10-01 00:00:00

abstract：:The basis for nucleolar dominance in mouse-human cell hybrids which contained all of the mouse chromosomes but an incomplete set of human chromosomes (M greater than H) was examined at the molecular level. S1 mapping data showed that these cells had the expected levels of steady-state rRNA transcribed from mouse ribos...

journal_title：Molecular and cellular biology

authors： Miesfeld R,Sollner-Webb B,Croce C,Arnheim N

更新日期：1984-07-01 00:00:00

abstract：:In the present study we have analyzed the genetic regulation of increased expression of transformation-associated traits, a process termed progression, in adenovirus type 5 (Ad5)-transformed secondary rat embryo cells. Somatic cell hybrids were formed between a highly progressed neomycin-resistant Ad5-transformed clon...

journal_title：Molecular and cellular biology

authors： Duigou GJ,Babiss LE,Iman DS,Shay JW,Fisher PB

更新日期：1990-05-01 00:00:00

abstract：:The Wnt-1 proto-oncogene is essential for proper development of the midbrain and is expressed in a spatially and temporally restricted manner during central nervous system development in mice. In vitro, the gene is specifically transcribed during the retinoic acid (RA)-induced neuroectodermal differentiation of the P1...

journal_title：Molecular and cellular biology

authors： St-Arnaud R,Moir JM

更新日期：1993-03-01 00:00:00

abstract：:Protein kinase GCN2 is a multidomain protein that contains a region homologous to histidyl-tRNA synthetases juxtaposed to the kinase catalytic moiety. Previous studies have shown that in response to histidine starvation, GCN2 phosphorylates eukaryotic initiation factor 2 (eIF-2), to induce the translational expression...

journal_title：Molecular and cellular biology

authors： Wek SA,Zhu S,Wek RC

更新日期：1995-08-01 00:00:00

abstract：:The DNA damage checkpoint is tightly controlled. After its activation, the checkpoint machinery is inactivated once lesions are repaired or undergoes adaptation if the DNA damage is unable to be repaired. Protein acetylation has been shown to play an important role in DNA damage checkpoint activation. However, the rol...

journal_title：Molecular and cellular biology

authors： Tao R,Xue H,Zhang J,Liu J,Deng H,Chen YG

更新日期：2013-11-01 00:00:00