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μCT based assessment of mechanical deformation of designed PTMC scaffolds.

Abstract：

BACKGROUND:Advances in rapid-prototyping and 3D printing technologies have enhanced the possibilities in preparing designed architectures for tissue engineering applications. A major advantage in custom designing is the ability to create structures with desired mechanical properties. While the behaviour of a designed scaffold can be simulated using bulk material properties, it is important to verify the behaviour of a printed scaffold at the microstructure level. OBJECTIVE:In this study we present an effective method in validating the mechanical behaviour of designed scaffolds using a μCT with an in-situ mechanical deformation device. METHODS:The scaffolds were prepared from biodegradable poly(trimethylene carbonate) (PTMC) by stereolithography and images obtained using a high-resolution μCT with 12.25μm isometric voxels. The data was processed (filtering, segmentation) and analysed (surface generation, registration) to extract relevant deformation features. RESULTS:The computed local deformation fields, calculated at sub-pore resolutions, displayed expected linear behaviour within the scaffold along the compressions axis. On planes perpendicular to this axis, the deformations varied by 150- 200μm. CONCLUSIONS:μCT based imaging with in-situ deformation provides a vital tool in validating the design parameters of printed scaffolds. Deformation fields obtained from micro-tomographic image volumes can serve to corroborate the simulated ideal design with the realized product.

journal_name

Clin Hemorheol Microcirc

journal_title

Clinical hemorheology and microcirculation

authors

Narra N,Blanquer SB,Haimi SP,Grijpma DW,Hyttinen J

doi

10.3233/CH-151931

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

99-108

issue

1

eissn

1386-0291

issn

1875-8622

pii

X146076G4810K41V

journal_volume

60

pub_type

杂志文章

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