Effects of cardiotonic pill on RBC rheologic abnormalities in HFD-induced mice and LPL deficient mice.

Abstract:

:The lipoprotein lipase deficient (LPL-/-) mice and high fat-diet (HFD) induced hypertriglyceridemic mice were used to investigate the effects of cardiotonic pill (CP) on RBC rheologic abnormalities. Mice were randomly divided into the following five groups: the control group; the untreated HFD group; the untreated LPL-/- group; the treated HFD group; and the treated LPL-/- group, and the treated HFD and LPL-/- mice were administered with CP twice a day (400 mg/kg/day) orally for four weeks. Then, plasma triglyceride (TG), RBC deformation index (DI), orientation index (DI)or and RBC electrophoretic time (EPT) were measured. Compared with the untreated HFD mice, TG level and EPT reduced and DI and (DI)or increased markedly in the treated HFD mice (P<0.05). However, compared with the untreated LPL-/- mice, these parameters in the treated LPL-/- mice had no statistically significant changes (P>0.05). Our data show that CP can lower plasma TG level and ameliorate RBC rheologic abnormalities in the HFD-induced hypertriglyceridemic mice, but it losses its capacity in the LPL deficient animals. The results indicate that LPL may be one of the important targets for CP regulating lipometabolism and rheologic abnormalities.

authors

Wang XW,Guo J,Wang XF,Chen XP,Wen ZY

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

281-8

issue

4

eissn

1386-0291

issn

1875-8622

journal_volume

40

pub_type

杂志文章
  • Modeling of stress relaxation of a semi-crystalline multiblock copolymer and its deformation behavior.

    abstract::Stress relaxation can strongly influence the shape-memory capability of polymers. Recently a modified Maxwell-Wiechert model comprising two Maxwell units and a single spring unit in parallel has been introduced to successfully describe the shape recovery characteristics of amorphous polyether urethanes. In this work w...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-151940

    authors: Yan W,Fang L,Heuchel M,Kratz K,Lendlein A

    更新日期:2015-01-01 00:00:00

  • What is the maximum duration to perform the hemorheological measurement for the human and mammals.

    abstract::The hemorheological performance of mammals and human will change with the time after the blood is withdraw from the subject. The whole blood apparent viscosity, erythrocyte deformability and aggregation of some mammals and human were measured. Our results showed that the hemorheological characteristics of mice, rats, ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Zhang J,Zhang X,Wang N,Fan Y,Ju H,Yang J,Wen J,Qu X

    更新日期:2004-01-01 00:00:00

  • Endothelial nitric oxide synthase expression in systemic and pulmonary circulation of streptozotocin induced diabetic rats: comparison using image analysis.

    abstract::To compare the level of endothelial nitric oxide synthase (eNOS) expression produced in heart and lung vascular tissue, the protein content was determined using Western blot analysis with the enhancement of image processing. Heart and lung extracts from 12 and 24 weeks from control (CON) and streptozotocin-induced dia...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Sridulyakul P,Chakraphan D,Bhattarakosol P,Patumraj S

    更新日期:2003-01-01 00:00:00

  • Hemorheology and heart rate variability: is there a relationship?

    abstract::The aim of the present study was to test the relationships between hemorheology and autonomic nervous system (ANS) activity in 23 sickle cell trait (SCT) carriers and 17 control subjects. Hemorheological parameters were assessed at rest. Nocturnal ANS activity was calculated from heart rate variability indices. Impair...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Connes P,Hue O,Hardy-Dessources MD,Boucher JH,Pichot V,Barthélémy JC

    更新日期:2008-01-01 00:00:00

  • A comparative study of the haemorheology of various breeds of dog.

    abstract::Haemorheological parameters in nine breeds of dog were examined. Whole blood viscosity at both high and low shear rates differed significantly between the breeds with a 50% difference between the highest and lowest viscosity at high shear rate and a 140% difference at low shear rate. Athletic breeds (Greyhounds, Deerh...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Bodey AR,Rampling MW

    更新日期:1998-07-01 00:00:00

  • Hemorheological disturbances in cerebrovascular diseases.

    abstract::The aim of the study was to evaluate the possible relationship of the hemorheological disturbances with the clinical symptoms and some risk factors (RF) for cerebrovascular diseases (CVD). The study included 68 patients with CVD, 29 with transient ischemic attacks (TIA) and 39 with chronic unilateral cerebral infarcti...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Velcheva I,Antonova N,Titianova E,Damianov P,Dimitrov N,Dimitrova V

    更新日期:2008-01-01 00:00:00

  • Alterations of serum erythropoietin and thrombopoietin levels in patients undergoing Coronary Artery Bypass Grafting (CABG).

    abstract:INTRODUCTION:The hormones erythropoietin (EPO) and thrombopoietin (TPO) are main regulators of erythro- and thrombopoiesis. Cell loss caused by operative procedures may alter serum levels of the hormones, resulting in well known phenomenons like reactice thrombocytosis. MATERIAL AND METHODS:Blood samples from 10 patie...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2011-1489

    authors: Wenzel F,Gettmann T,Zimmermann N,Giers G

    更新日期:2011-01-01 00:00:00

  • Red blood cell (RBC) surface acetylcholinesterase showing a hemorheological pattern during glaucoma treatment.

    abstract:BACKGROUND:Glaucoma is currently attributed to two different possible pathogenetic mechanisms: mechanical (the ocular damage is induced by physical injury), and vascular (the ocular damage is sustained by ischemia of the optic nerve head). AIM:We considered the possibility that several anti-glaucoma drugs (beta-blocke...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cicco G,Vetrugno M,Rotelli MT,Sborgia G,Pennetta M,Vico PP,Memeo V,Nitti L,Sborgia C

    更新日期:2006-01-01 00:00:00

  • Controlled reperfusion decreased reperfusion induced oxidative stress and evoked inflammatory response in experimental aortic-clamping animal model.

    abstract:UNLABELLED:Revascularization after long term aortic ischaemia in vascular surgery induces reperfusion injury accompanied with oxidative stress and inflammatory responses. The hypothesis of this study was that the aortic occlusion followed by controlled reperfusion (CR) can reduce the ischaemia-reperfusion injury, the s...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-152038

    authors: Jancsó G,Arató E,Hardi P,Nagy T,Pintér Ö,Fazekas G,Gasz B,Takacs I,Menyhei G,Kollar L,Sínay L

    更新日期:2016-09-12 00:00:00

  • Effects of haemoglobin levels on the sublingual microcirculation in pregnant women.

    abstract::Anemia in pregnant women is associated with increased maternal and perinatal mortality and represents an important economic burden in many developing countries. Our goal was to evaluate the impact of anemia on the capillary network during pregnancy. Therefore, we compared microcirculatory parameters of anemic pregnant...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-162064

    authors: Sharawy N,Hussein A,Hossny O,Refaa A,Saka A,Mukhtar A,Whynot S,George R,Lehmann C

    更新日期:2016-11-25 00:00:00

  • Acute responses of platelet count and ADP-induced platelet aggregation to different high intensity interval exercise modes.

    abstract:BACKGROUND:Platelet activation is associated with abdominal obesity and exercise training is an important modulator of body weight. OBJECTIVE:We investigated the effects of two high intensity interval exercise (HIIE) protocols of different intensity and duration on platelet indices and platelet aggregation in overweig...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200848

    authors: Ahmadizad S,Rahmani H,Khosravi N,Falakdin Z,Connes P,Daraei A

    更新日期:2020-01-01 00:00:00

  • Confocal myography for the study of hypertensive vascular remodelling.

    abstract::Hypertension is associated with vascular structural alterations known as "vascular remodelling", which initially are adaptive but in the long run, lead to vascular damage and loss of function. Despite decades of study, there is still modest information on the 3-dimensional (3D) arrangement of vascular cells and extrac...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:

    authors: Arribas SM,González JM,Briones AM,Somoza B,Daly CJ,Vila E,González MC,McGrath JC

    更新日期:2007-01-01 00:00:00

  • Human erythrocyte filterability at low driving pressure.

    abstract::In this study, the human RBC capillary flow has been modeled by passing 11 microl of RBC suspension (Hematocrit = 6%) in phosphate buffer solution (PBS) of a viscosity of 1 and 2.6 cP (in the presence of 2% Dextran) through 5 microm pore diameter polycarbonate Nuclepore filters. We have developed a digitally controlle...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2009-1242

    authors: Ginsbourg S,Levin S,Einav S,Korenstein R

    更新日期:2009-01-01 00:00:00

  • Subcellular localization of the chemotherapeutic agent doxorubicin in renal epithelial cells and in tumor cells using correlative light and electron microscopy.

    abstract:BACKGROUND:Doxorubicin is a cytostatic drug from the group of anthracycline antibiotics that is widely used as a chemotherapeutic agent. Side effects of the active substance include cardiotoxicity and nephrotoxicity. Doxorubicin-treated renal epithelial cells and (sarcoma) tumors are examined by correlative light and e...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-199212

    authors: Asam C,Buerger K,Felthaus O,Brébant V,Rachel R,Prantl L,Witzgall R,Haerteis S,Aung T

    更新日期:2019-01-01 00:00:00

  • The effect of aging on blood and plasma viscosity. An 11.6 years follow-up study.

    abstract:OBJECTIVE:Alterations of blood and plasma viscosity can promote atherosclerosis. The relationship between viscosity and aging is still controversial. The present study evaluated the influence of aging on blood and plasma viscosity in a group of subjects followed for 11.6 years. METHODS:Forty-five subjects have been ev...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2010-1367

    authors: Carallo C,Irace C,De Franceschi MS,Coppoletta F,Tiriolo R,Scicchitano C,Scavelli F,Gnasso A

    更新日期:2011-01-01 00:00:00

  • Numerical investigation on red blood cell dynamics in microflow: Effect of cell deformability.

    abstract::The radial dispersion of red blood cells (RBCs) near the vessel wall can significantly affect the transport dynamics in small vessels. The radial dispersion of RBCs is mainly caused by collisions between RBCs and this can be enhanced by aggregation. The objective of this study is to numerically investigate on the effe...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-16128

    authors: Ju M,Leo HL,Kim S

    更新日期:2017-01-01 00:00:00

  • Endothelial function, fluid dynamics, hemorheology implications for clinical and preclinical vascular disease and implications for the ESCHM.

    abstract::Vascular homeostasis involves endothelial function, smooth muscle function, central hemodynamics, and their interactions with blood. In this complex balance, the role of hemorheological parameters still needs to be defined, particularly with regards to its clinical implications. While the importance of microcirculatio...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-168017

    authors: Gori T

    更新日期:2016-01-01 00:00:00

  • Laparoscopy-guided percutaneous microwave ablation for symptomatic 12.8 cm hepatic hemangioma with low blood loss and short hospital stay post-operation: A case report and literature review.

    abstract::We described a patient with symptomatic giant hepatic hemangioma (GHH) treated with laparoscopic guided percutaneous microwave ablation (MWA). A 58 years' old woman was referred to our hospital who presented with upper abdominal distension and appetite loss for more than 1 year. The medical history included untreated ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-200922

    authors: Zhang HL,Meng HB,Li XL,Sun LP,Lu F,Xu HX,Yu SY

    更新日期:2020-10-13 00:00:00

  • Plasma viscosity, functional fibrinogen, and platelet reactivity in vascular surgery patients.

    abstract:BACKGROUND:Platelet reactivity changes with shear stress, which in turn depends on whole blood and plasma viscosity (PV). Platelets interact with fibrinogen during thrombus formation, and fibrinogen is a determinant of PV. The respective role of PV and fibrinogen on platelet function is still unclear. METHODS:30 patie...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-141866

    authors: Ranucci M,Ranucci M,Laddomada T,Baryshnikova E,Nano G,Trimarchi S

    更新日期:2015-01-01 00:00:00

  • Performance evaluation of the Anysis-200 platelet function analyzer in cardiac patients.

    abstract:BACKGROUND:Platelet function analysis is crucial in assessing the hemostatic status to evaluate congenital and acquired platelet function defects. The Anysis-200 analyzer is a new automated lab-on-a-chip-based platelet function analyzer. OBJECTIVE:We aimed to evaluate a new platelet function analyzing system, the Anys...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-190801

    authors: Park SJ,Yoon J,Seo HS,Lim CS

    更新日期:2020-02-24 00:00:00

  • Plasma nitric oxide level is correlated with microvascular functions in the peripheral arterial disease.

    abstract::At present there is no widely accepted biomarker for monitoring of vascular functions. The purpose of this prospective study was to investigate the association of some blood biomarkers with vascular reactivity in patients with peripheral arterial diseases (PAD). A prospective evaluation was made of 3 groups comprising...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-16143

    authors: Akkoca M,Usanmaz SE,Koksoy C,Bengisun U,Demirel-Yilmaz E

    更新日期:2017-01-01 00:00:00

  • Micro-vascular medicine and proteomics.

    abstract::A new technique is sweeping the world, and changing the course of human work and life. It is impacting upon models, methods and the development of medical research. In the development of this new technique, a huge quantity of experimental research and clinical practice has proved that many human diseases have a close ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章,评审

    doi:

    authors: Zhang HG,Xiu RJ

    更新日期:2003-01-01 00:00:00

  • Contrast-enhanced ultrasound versus CT and operative findings in evaluation of renal vein aneurysm with AV fistula.

    abstract::We report the case of a 61-year-old patient admitted to our hospital owing to recent nonspecific abdominal pain. Five years earlier he had been treated with a graft owing to thoracic and abdominal aortic aneurysm with dissection. He now showed a left renal vein aneurysm with a diameter of 11x7.5 cm. This case demonstr...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Clevert DA,Stickel M,Kopp R,Weidenhagen R,Fink C,Jauch KW,Reiser M

    更新日期:2008-01-01 00:00:00

  • Assessment of skin microvascular endothelial function in patients with acute unilateral vestibular syndrome.

    abstract::Abnormalities in labyrinth vasculature, resulting in labyrinth ischemia may be responsible for acute unilateral vestibular syndrome (AVS). However, since no tools for the study of the labyrinth microvasculature are available in clinical settings, labyrinth microvascular abnormalities in AVS patients (AVS-pts) can only...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-2012-1554

    authors: Rossi M,Casani AP,Pesce M,Cerchiai N,Santoro G,Franceschini SS

    更新日期:2013-01-01 00:00:00

  • Influence of nanoporous poly(ether imide) particle extracts on human aortic endothelial cells (HAECs).

    abstract::Accumulated uremic toxins like indoxyl sulphate, hippuric acid and p-cresyl sulphates in renal failure patients stimulate proinflammatory effects, and consequently kidney and cardiovascular diseases. Low clearance rate of these uremic toxins from the blood of uremic patients by conventional techniques like hemodialysi...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-168046

    authors: Kumar RK,Basu S,Lemke HD,Jankowski J,Kratz K,Lendlein A,Tetali SD

    更新日期:2016-01-01 00:00:00

  • Red blood cell deformability, aggregability and cytosolic calcium concentration in normal tension glaucoma.

    abstract:AIM:The aim of the study was to determine the role of some erythrocyte patterns (Red Blood Cell deformability, aggregability, cytosolic calcium concentration) in normal tension glaucoma (NTG), compared with primary open angle glaucoma (POAG) and normal subjects. MATERIAL AND METHODS:Ninety patients entered the study, ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Vetrugno M,Cicco G,Cantatore F,Arnese L,Delle Noci N,Sborgia C

    更新日期:2004-01-01 00:00:00

  • A new simple cone-plate viscometer for hemorheology.

    abstract::The aim of this work was to evaluate a new automatic cone-plate viscometer (LBY-N6, PRECIL, Beijing, China) which was designed for clinical measurements of blood and plasma viscosities. Standard calibrating oils of viscosity varying from 1.85 to 20.5 mPas (conforming to ASTM Standard) were used to test the precision a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Wang X,Liao FL,Stoltz JF

    更新日期:1998-09-01 00:00:00

  • Changes in the microcirculation at the superficial and deeper levels in lymphoedema: the effects and results of massage, compression, exercise and benzopyrones on these levels during treatment.

    abstract::This review starts with a brief description of the pioneering work done by J.R. Casley-Smith when he looked at the pathophysiological changes that occur, and transport from the blood vessels, through the interstitium to the lymphatics and lymphatic uptake, with the electron microscope. Collaboration with, and further ...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Casley-Smith JR

    更新日期:2000-01-01 00:00:00

  • Modulating human mesenchymal stem cells using poly(n-butyl acrylate) networks in vitro with elasticity matching human arteries.

    abstract::Non-swelling hydrophobic poly(n-butyl acrylate) network (cPnBA) is a candidate material for synthetic vascular grafts owing to its low toxicity and tailorable mechanical properties. Mesenchymal stem cells (MSCs) are an attractive cell type for accelerating endothelialization because of their superior anti-thrombosis a...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:10.3233/CH-189418

    authors: Wang W,Xu X,Li Z,Kratz K,Ma N,Lendlein A

    更新日期:2019-01-01 00:00:00

  • Hemorheological methods in drug research.

    abstract::Development of new drugs is a sophisticated process that requires several, different methods. In our experiments we have applied two rheological models to study experimental and clinically used drugs. The antioxidant properties of several agents were estimated by erythrocyte filtration technique. The known antioxidant...

    journal_title:Clinical hemorheology and microcirculation

    pub_type: 杂志文章

    doi:

    authors: Marton Z,Halmosi R,Alexy T,Horvath B,Toth A,Feher G,Koltai K,Kesmarky G,Habon T,Sumegi B,Hideg K,Toth K

    更新日期:2004-01-01 00:00:00