Abstract:
:When perfused internally through crayfish giant axons, pronase removed sodium inactivation more than three times as fast at -100 mV as compared with -30 mV. N-bromoacetamide, applied internally, removed sodium inactivation twice as fast at -100 mV as at -30 mV, and the relative rate of removal declined with membrane depolarization in proportion to steady-state sodium inactivation. We conclude that in the closed conformation the sodium inactivation gate is partially protected from destruction by N-bromoacetamide and pronase.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Salgado VL,Yeh JZ,Narahashi Tdoi
10.1016/S0006-3495(85)83952-7subject
Has Abstractpub_date
1985-04-01 00:00:00pages
567-71issue
4eissn
0006-3495issn
1542-0086pii
S0006-3495(85)83952-7journal_volume
47pub_type
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