Abstract:
:It has long been recognized that protein dynamical processes occur over a wide temporal range. However, the functionality of this spectrum of events remains unclear. In this work, a generalized noise function analysis is applied to a collection of diverse protein dynamical systems. It is shown that a power law model with an oscillatory component can adequately describe the time course of a variety of processes. These results suggest that under the appropriate conditions, proteins are in a metastable state. A microscopic, chemical kinetic model based on a Poisson distribution of activation energies is presented. From this model specific functional forms for the parameters of the generalized noise model can be derived. Additionally, a model is presented to described kinetic hole burning effects observed at low temperatures. Scaling laws are derived for these models that provide a connection with the generalized noise analysis.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Dewey TG,Bann JGdoi
10.1016/S0006-3495(92)81603-Xsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
594-8issue
2eissn
0006-3495issn
1542-0086pii
S0006-3495(92)81603-Xjournal_volume
63pub_type
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