Abstract：
:In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to develop new pharmacological treatments, in vivo animal models that present features similar to those seen in TLE patients have been developed during the last four decades. Some of these models are based on the systemic administration of chemoconvulsants to induce an initial precipitating injury (status epilepticus) that is followed by the appearance of recurrent seizures originating from limbic structures. In this paper we will review two chemically-induced TLE models, namely the kainic acid and pilocarpine models, which have been widely employed in basic epilepsy research. Specifically, we will take into consideration their behavioral, electroencephalographic and neuropathologic features. We will also evaluate the response of these models to anti-epileptic drugs and the impact they might have in developing new treatments for TLE.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Lévesque M,Avoli M,Bernard Cdoi
10.1016/j.jneumeth.2015.03.009subject
Has Abstractpub_date
2016-02-15 00:00:00pages
45-52eissn
0165-0270issn
1872-678Xpii
S0165-0270(15)00091-6journal_volume
260pub_type
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journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
pub_type： 杂志文章,评审
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journal_title：Journal of neuroscience methods
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