An initial validation of the Virtual Environment Grocery Store.

Abstract:

BACKGROUND:Virtual reality-based neuropsychological assessments proffer the potential to address the limited ecological validity of pen-and-paper measures of memory. NEW METHOD:To investigate the construct validity of a newly developed virtual reality-based multiple errands task, the Virtual Environment Grocery Store (VEGS), two studies were performed. COMPARISON WITH EXISTING METHOD(S):In Study 1, we explored construct validity via comparison of traditional neuropsychological measures of memory and executive functioning with a low distraction condition of the VEGS. In Study 2, a new sample was used to compare traditional neuropsychological measures of memory and executive functioning with a high distraction condition of the VEGS. RESULTS:Performances on the VEGS memory tasks (in Study 1: low distraction condition) and the traditional neuropsychological assessments of memory were positively correlated, indicating that memory for VEGS content was similar to memory for traditional paper-and-pencil measures. Again, in Study 2, performances on the VEGS memory tasks correlated with the traditional neuropsychological assessments of memory, indicating that memory for VEGS content was similar to memory for traditional paper-and-pencil measures. As expected, though, the addition of distractors into the virtual environment resulted in significant correlations with traditional measures of inhibitory control. CONCLUSIONS:The VEGS has the advantage over traditional measures of providing objective measurement of individual components of memory in simulations of everyday activities.

journal_name

J Neurosci Methods

authors

Parsons TD,McMahan T

doi

10.1016/j.jneumeth.2017.07.027

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

13-19

eissn

0165-0270

issn

1872-678X

pii

S0165-0270(17)30270-4

journal_volume

291

pub_type

杂志文章
  • A voltage-controlled current source with regulated electrode bias-voltage for safe neural stimulation.

    abstract::A current source for neural stimulation is presented which converts arbitrary voltage signals to current-controlled signals while regulating the offset-voltage across the stimulation electrodes in order to keep the electrodes in an electrochemical state that allows for injecting a maximum charge. The offset-voltage ca...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2008.03.016

    authors: Schuettler M,Franke M,Krueger TB,Stieglitz T

    更新日期:2008-06-30 00:00:00

  • l-Glutamate in Middlebrook 7H9 culture medium upregulates matrix metalloproteinase-2 secretion from human astrocytoma cells.

    abstract::Matrix metalloproteinases (MMPs) are implicated in the pathology of CNS tuberculosis. Whilst investigating the secretion of MMP-2 from human U373-MG astrocytoma cells, we observed elevated MMP-2 secretion in response to Middlebrook 7H9 media but not to Mycobacterium tuberculosis itself. Middlebrook 7H9 media did not s...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2008.06.007

    authors: Harris JE,Friedland JS

    更新日期:2008-08-30 00:00:00

  • New developments in an "expanded stick" model for coding, graphic representation and metric analysis of tracer-filled or Golgi-impregnated neurons, including spines and varicosities.

    abstract::A new data model allowing the coding, graphic representation and metric analysis of dendritic and axonal processes including spines and varicosities, is here described. The model is implemented in an interactive light microscope-computer system and stores the three-dimensional coordinates of the selected neuronal poin...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/0165-0270(91)90022-r

    authors: Freire M

    更新日期:1991-03-01 00:00:00

  • Quantitative 3-D analysis of GFAP labeled astrocytes from fluorescence confocal images.

    abstract:BACKGROUND:There is a need for effective computational methods for quantifying the three-dimensional (3-D) spatial distribution, cellular arbor morphologies, and the morphological diversity of brain astrocytes to support quantitative studies of astrocytes in health, injury, and disease. NEW METHOD:Confocal fluorescenc...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2015.02.014

    authors: Kulkarni PM,Barton E,Savelonas M,Padmanabhan R,Lu Y,Trett K,Shain W,Leasure JL,Roysam B

    更新日期:2015-05-15 00:00:00

  • Visualization of dendritic morphology of cortical projection neurons by retrograde axonal tracing.

    abstract::Currently there is no reliable retrograde tracing technique for visualization of dendritic morphologies of projection neurons. Here we describe a simple and efficient method that can be used to label neurons in Golgi-like fashion. The approach relies on activity-dependent uptake of tracer. For this purpose we inject t...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/0165-0270(93)90055-v

    authors: Jiang X,Johnson RR,Burkhalter A

    更新日期:1993-10-01 00:00:00

  • Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons.

    abstract:BACKGROUND:The light-induced release of neurotransmitters from caging chromophores provides a powerful means to study the underlying receptors in a physiologically relevant context. Surprisingly, most caged neurotransmitters, including the widely used 4-methoxy-7-nitroindolinyl (MNI)-glutamate, show strong antagonism a...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2017.10.013

    authors: Passlick S,Ellis-Davies GCR

    更新日期:2018-01-01 00:00:00

  • A modified and highly sensitive Golgi-Cox method to enable complete and stable impregnation of embryonic neurons.

    abstract::The FD Rapid GolgiStain Kit (FD NeuroTechnologies, Inc., Ellicott City, MD) was developed using an improved Golgi-Cox impregnation method to provide stable, sensitive, and convenient staining of mature neurons. However, embryonic neurons cannot be clearly visualized using this method. We have further improved the Golg...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2012.06.007

    authors: Koyama Y,Tohyama M

    更新日期:2012-07-30 00:00:00

  • Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS.

    abstract::An ongoing question in neuroscience is how the peripheral nervous system can repair itself following an injury or insult whereas the central nervous system has a profoundly limited ability for repair. The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章,评审

    doi:10.1016/j.jneumeth.2020.108623

    authors: El Seblani N,Welleford AS,Quintero JE,van Horne CG,Gerhardt GA

    更新日期:2020-04-01 00:00:00

  • A multifunctional pipette for localized drug administration to brain slices.

    abstract::We have developed a superfusion method utilizing an open-volume microfluidic device for administration of pharmacologically active substances to selected areas in brain slices with high spatio-temporal resolution. The method consists of a hydrodynamically confined flow of the active chemical compound, which locally st...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2013.08.012

    authors: Ahemaiti A,Ainla A,Jeffries GD,Wigström H,Orwar O,Jesorka A,Jardemark K

    更新日期:2013-10-15 00:00:00

  • Validation studies of the human movement analysis panel for hand/arm performance.

    abstract::The human movement analysis panel (HMAP) measures separable components of arm motion and simple and complex finger coordination. HMAP testing takes 30min to administer. In separate experiments we have validated the HMAP against the standard grooved pegboard and measures of gait speed, and demonstrated important learni...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2007.06.015

    authors: Smith CD,Walton A,Slevin JT,Gerhardt GA,Umberger G,Smoot K,Schulze E,Gash D

    更新日期:2007-09-30 00:00:00

  • Automatic seizure detection in EEG using logistic regression and artificial neural network.

    abstract::The detection of epileptiform discharges in the EEG is an important component in the diagnosis of epilepsy. In this study, multiple signal classification (MUSIC), autoregressive (AR) and periodogram methods were used to get power spectra in patients with absence seizure. The EEG power spectra were used as an input to ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2005.04.009

    authors: Alkan A,Koklukaya E,Subasi A

    更新日期:2005-10-30 00:00:00

  • A semi-correlative technique for the subcellular localization of proteins in Drosophila synapses.

    abstract::The neuromuscular junction (NMJ) in Drosophila larvae serves as an important model system to study synaptic vesicle recycling, plasticity, development, and organelle trafficking in nerve terminals. Here we provide a protocol that reliably localizes proteins subcellularly in this system in combination with good preserv...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2009.10.010

    authors: Jiao W,Shupliakov A,Shupliakov O

    更新日期:2010-01-15 00:00:00

  • Experimental microneurosurgery of the trigeminal nerve: surgical technique for ganglionectomy and rhizotomy in the cat.

    abstract::The techniques of two experimental surgical operations on the trigeminal nerve are described, namely, excision of the trigeminal ganglion (ganglionectomy) and division of the trigeminal root (rhizotomy), in the cat. These techniques have been developed with the specific aims of achieving the trigeminal lesion and also...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/0165-0270(95)00129-8

    authors: Sakas DE,Whittaker K,Abbasi KH,Zervas NT

    更新日期:1996-04-01 00:00:00

  • Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli.

    abstract::We have examined the stability and sources of variation within the nociceptive model of rat hind paw withdrawal from an under-glass radiant stimulus (Hargreaves et al., 1988) using a system where stimulus intensity and floor temperature can be controlled and reproducibly changed. The current study demonstrates that: (...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(97)00097-6

    authors: Dirig DM,Salami A,Rathbun ML,Ozaki GT,Yaksh TL

    更新日期:1997-10-03 00:00:00

  • The feasibility of quantitative MRI of perivascular spaces at 7T.

    abstract:BACKGROUND:Dilated brain perivascular spaces (PVSs) are found to be associated with many conditions, including aging, dementia, and Alzheimer's disease (AD). Conventionally, PVS assessment is mainly based on subjective observations of the number, size and shape of PVSs in MR images collected at clinical field strengths...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2015.09.001

    authors: Cai K,Tain R,Das S,Damen FC,Sui Y,Valyi-Nagy T,Elliott MA,Zhou XJ

    更新日期:2015-12-30 00:00:00

  • Is it possible to generate cerebral evoked potentials with a mechanical stimulus from the duodenum in rats?

    abstract::The study aim was to develop a model to generate cerebral evoked potentials (CEPs) by mechanical distention of the duodenum in rats. Twenty Sprague-Dawley rats were anaesthetized and the EEG recorded from the left and right somatosensory cortices (S1L, S1R). A balloon catheter was implanted into the duodenum. A pneuma...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2007.01.014

    authors: Murrell JC,Mitchinson SL,Johnstone AC,Johnson CB,Barnes GR

    更新日期:2007-05-15 00:00:00

  • Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography.

    abstract:BACKGROUND:Advancement in clinically relevant studies like seizure interruption using functional neuro imaging tools has shown that specific changes in hemodynamics precede and accompany seizure onset and propagation. However, preclinical seizure experiments need to be conducted in awake animals with images reconstruct...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2014.10.018

    authors: Zhang T,Zhou J,Carney PR,Jiang H

    更新日期:2015-01-30 00:00:00

  • The use of in vivo direct drug application to assess neural regulation of muscle properties.

    abstract::Skeletal muscle is a convenient model system for studying basic questions on the neural regulation of synaptogenesis and of many properties of sarcolemma and contractile apparatus. The study of the neural signals involved in a particular regulation and of the mediating intracellular pathways, requires the chronic appl...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(00)00352-6

    authors: Buffelli M,Busetto G,Cangiano A

    更新日期:2001-04-30 00:00:00

  • The strength and spread of the electric field induced by transcranial rotating permanent magnet stimulation in comparison with conventional transcranial magnetic stimulation.

    abstract:BACKGROUND:Weak or low intensity transcranial stimulation of the brain, such as low field magnetic stimulation and electrical stimulation, can produce significant functional and therapeutic neuromodulatory effects. NEW METHOD:We have recently developed a portable wearable multifocal brain stimulator called transcrania...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2018.09.002

    authors: Helekar SA,Convento S,Nguyen L,John BS,Patel A,Yau JM,Voss HU

    更新日期:2018-11-01 00:00:00

  • Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes.

    abstract::Xenopus laevis oocytes were injected with synthetic mRNA coding for a rat VMAT2 mutant (rVMAT2-I483A/L484A) shown previously to be retained on the plasma membrane as a result of a presumed reduction of endocytosis. Binding of the specific VMAT inhibitor [3H]dihydrotetrabenazine indicated that expression did occur at a...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2003.10.010

    authors: Whitley J,Parsons J,Freeman J,Liu Y,Edwards RH,Near JA

    更新日期:2004-02-15 00:00:00

  • Integration of confocal and atomic force microscopy images.

    abstract::Atomic force microscopy (AFM) provides the possibility to map the 3D structure of viewed objects with a nanometric resolution, which cannot be achieved with other imaging methods such as conventional video imaging and confocal fluorescent microscopy. Video imaging with CCD cameras can provide an analysis of biological...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2008.09.034

    authors: Kondra S,Laishram J,Ban J,Migliorini E,Di Foggia V,Lazzarino M,Torre V,Ruaro ME

    更新日期:2009-02-15 00:00:00

  • Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice.

    abstract::We investigated the usefulness of YFP-H transgenic mice [Neuron 28 (2000) 41] which express yellow fluorescent protein (YFP) in a restricted subset of neurons to study Wallerian degeneration in the PNS. Quantification of YFP positive axons and myelin basic protein (MBP) immunocytochemistry revealed that YFP was random...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2003.10.016

    authors: Beirowski B,Berek L,Adalbert R,Wagner D,Grumme DS,Addicks K,Ribchester RR,Coleman MP

    更新日期:2004-03-15 00:00:00

  • A cranial window imaging method for monitoring vascular growth around chronically implanted micro-ECoG devices.

    abstract::Implantable neural micro-electrode arrays have the potential to restore lost sensory or motor function to many different areas of the body. However, the invasiveness of these implants often results in scar tissue formation, which can have detrimental effects on recorded signal quality and longevity. Traditional histol...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2013.06.001

    authors: Schendel AA,Thongpang S,Brodnick SK,Richner TJ,Lindevig BD,Krugner-Higby L,Williams JC

    更新日期:2013-08-15 00:00:00

  • A decerebrate, artificially-perfused in situ preparation of rat: utility for the study of autonomic and nociceptive processing.

    abstract::By extending established technology, we have developed a relatively simple in situ preparation from juvenile rat that overcomes some technical restrictions present in vivo (e.g. need for anaesthesia, mechanical instability for intracellular recording and control over the extracellular milieu). The in situ preparation ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2006.01.011

    authors: Pickering AE,Paton JF

    更新日期:2006-09-15 00:00:00

  • Real-time extracellular measurement of neurotransmitters in conscious sheep.

    abstract::Measurements of neurotransmitters in conscious animals have been restrictive in real-time. The use of specific enzymes within an amperometric probe, based upon a microdialysis membrane, may overcome some of these problems. I report the use of such a probe, with different perfusions of enzymes, to allow real-time measu...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(96)02175-9

    authors: Cook CJ

    更新日期:1997-04-04 00:00:00

  • A semi-automated algorithm for studying neuronal oscillatory patterns: a wavelet-based time frequency and coherence analysis.

    abstract::In many experimental designs, animal observation is associated with local field potential (LFP) recordings in order to find correlations between behavior dynamics and neuronal activity. In such cases, relevant behaviors can occur at different times during free-running recordings and should be put together by the time ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2007.08.027

    authors: Romcy-Pereira RN,de Araujo DB,Leite JP,Garcia-Cairasco N

    更新日期:2008-01-30 00:00:00

  • Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test.

    abstract:BACKGROUND:Evaluation of motor deficits in rodents is mostly restricted to limb motor tests that are often high stressors for the animals. NEW METHOD:To test rodents for orofacial motor impairments in a stress-free environment, we established the pasta gnawing test by measuring the biting noise of mice that eat a piec...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2016.10.006

    authors: Rabl R,Horvath A,Breitschaedel C,Flunkert S,Roemer H,Hutter-Paier B

    更新日期:2016-12-01 00:00:00

  • Caloric stimulation of ampullar receptors: a new method to produce mechanically-evoked responses in frog semicircular canals.

    abstract::A microthermistor positioned close to the exposed posterior semicircular canal in isolated labyrinth preparations of the frog was used to stimulate the sensory organ. Our results indicated that, depending on the position of the heater, the induced endolymphatic convection currents may result in either excitatory or in...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(99)00021-7

    authors: Zucca G,Botta L,Valli S,Giannoni B,Mira E,Perin P,Valli P

    更新日期:1999-05-01 00:00:00

  • A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays.

    abstract::Many neurophysiological experiments on rodents and non-human primates involve the implantation of more than one multi-electrode array to record from many regions of the brain. So called 'floating' microelectrode arrays are implanted in cortical regions of interest and are coupled via a flexible cable to their connecto...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2010.02.006

    authors: Chhatbar PY,von Kraus LM,Semework M,Francis JT

    更新日期:2010-05-15 00:00:00

  • Pharmacological validation of a novel home cage activity counter in mice.

    abstract::Many behavioural tests in rodents are based on the premise that basal locomotor activity of the animals is similar between the tested groups. The measurement of basal home cage activity is therefore an essential parameter, that should be included in all studies which employ tests of anxiety or cognition. Currently ava...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2007.01.008

    authors: Ganea K,Liebl C,Sterlemann V,Müller MB,Schmidt MV

    更新日期:2007-05-15 00:00:00