Abstract：
:Force can drive conformational changes in proteins, as well as modulate their stability and the affinity of their complexes, allowing a mechanical input to be converted into a biochemical output. These properties have been utilised by nature and force is now recognised to be widely used at the cellular level. The effects of force on the biophysical properties of biological systems can be large and varied. As these effects are only apparent in the presence of force, studies on the same proteins using traditional ensemble biophysical methods can yield apparently conflicting results. Where appropriate, therefore, force measurements should be integrated with other experimental approaches to understand the physiological context of the system under study.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Chen Y,Radford SE,Brockwell DJdoi
10.1016/j.sbi.2015.02.001subject
Has Abstractpub_date
2015-02-01 00:00:00pages
89-99eissn
0959-440Xissn
1879-033Xpii
S0959-440X(15)00010-Xjournal_volume
30pub_type
杂志文章,评审abstract：:A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Structural Biology. ...
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