Translational studies exploring neuroplasticity associated with motor skill learning and the regulatory role of the dopamine system.

Abstract:

:Cerebral palsy (CP) is a heterogeneous group of neurodevelopmental disorders associated with lifelong motor impairment and disability. Current intervention programmes aim to capitalize on the neuroplasticity of the undamaged part of the brain to improve motor functions, by engaging individuals in active motor learning and training. In this review, we highlight recent animal studies (1) exploring cellular and molecular mechanisms contributing to neuroplasticity during motor training, (2) assessing the functional role of the mesocortical dopaminergic system in motor skill learning, and (3) exploring the impact of naturally occurring genetic variation in dopamine-related gene expression on the acquisition and performance of fine motor skills. Finally, the potential influence of the dopamine system on the outcome of motor learning interventions in cerebral palsy is discussed.

journal_name

Dev Med Child Neurol

authors

Diaz Heijtz R,Forssberg H

doi

10.1111/dmcn.12692

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

10-4

eissn

0012-1622

issn

1469-8749

journal_volume

57 Suppl 2

pub_type

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