Aspects of carbohydrate metabolism in developing brain.

Abstract:

:This review considers carbohydrate metabolism in the developing brain, in particular the proportion of glucose metabolized via the pentose phosphate pathway. Although small in amount, this fraction serves a vital rôle in some aspects of brain function. Evidence is presented that the pentose phosphate pathway subserves different functions as the developing brain progresses through the stages of growth and myelination to full neurological competence. The general aspects considered are the changing patterns of brain enzymes during development; the flux of glucose through the alternative pathways of glucose metabolism in the developing brain; the functional significance of the pentose phosphate pathway; and the regional and functional association of the pentose phosphate pathway activity and the detoxication of biogenic amínes.

journal_name

Dev Med Child Neurol

authors

Baquer NZ,Hothersall JS,McLean P,Greenbaum AL

doi

10.1111/j.1469-8749.1977.tb08027.x

subject

Has Abstract

pub_date

1977-02-01 00:00:00

pages

81-104

issue

1

eissn

0012-1622

issn

1469-8749

journal_volume

19

pub_type

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